Search Results - "Miller, Megan B"

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice by Chakroborty, Shreaya, Goussakov, Ivan, Miller, Megan B, Stutzmann, Grace E

“…Presenilin mutations result in exaggerated endoplasmic reticulum (ER) calcium release in cellular and animal models of Alzheimer's disease (AD). In this study,…”
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NMDA-Mediated Ca2+ Influx Drives Aberrant Ryanodine Receptor Activation in Dendrites of Young Alzheimer's Disease Mice by Goussakov, Ivan, Miller, Megan B, Stutzmann, Grace E

“…Deficits in synaptic function, particularly through NMDA receptors (NMDARs), are linked to late-stage cognitive impairments in Alzheimer's disease (AD). At…”
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Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease by Chakroborty, Shreaya, Briggs, Clark, Miller, Megan B, Goussakov, Ivan, Schneider, Corinne, Kim, Joyce, Wicks, Jaime, Richardson, Jill C, Conklin, Vincent, Cameransi, Benjamin G, Stutzmann, Grace E

“…Alzheimer's disease (AD) is a devastating neurodegenerative condition with no known cure. While current therapies target late-stage amyloid formation and…”
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Evaluation of the Phosphoproteome of Mouse Alpha 4/Beta 2-Containing Nicotinic Acetylcholine Receptors In Vitro and In Vivo by Miller, Megan B, Wilson, Rashaun S, Lam, TuKiet T, Nairn, Angus C, Picciotto, Marina R

“…Activation of nicotinic acetylcholine receptors containing α4 and β2 subunits (α4/β2* nAChRs) in the mammalian brain is necessary for nicotine reinforcement…”
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NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice by Goussakov, Ivan, Miller, Megan B, Stutzmann, Grace E

“…Deficits in synaptic function, particularly through NMDA receptors (NMDARs), are linked to late-stage cognitive impairments in Alzheimer's disease (AD). At…”
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Neuronal Rho GEFs in Synaptic Physiology and Behavior by Miller, Megan B., Yan, Yan, Eipper, Betty A., Mains, Richard E.

“…In the mammalian brain, the majority of excitatory synapses are housed in micron-sized dendritic protrusions called spines, which can undergo rapid changes in…”
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Alternate promoter usage generates two subpopulations of the neuronal RhoGEF Kalirin‐7 by Miller, Megan B., Yan, Yan, Wu, Yi, Hao, Bing, Mains, Richard E., Eipper, Betty A.

“…Kalirin (Kal), a dual Rho GDP/GTP exchange factor (GEF), plays essential roles within and outside the nervous system. Tissue‐specific, developmentally…”
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An N-terminal Amphipathic Helix Binds Phosphoinositides and Enhances Kalirin Sec14 Domain-mediated Membrane Interactions by Miller, Megan B., Vishwanatha, Kurutihalli S., Mains, Richard E., Eipper, Betty A.

“…Previous studies revealed an essential role for the lipid-binding Sec14 domain of kalirin (KalSec14), but its mechanism of action is not well understood…”
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Peptidylglycine α‐amidating monooxygenase heterozygosity alters brain copper handling with region specificity by Gaier, Eric D., Miller, Megan B., Ralle, Martina, Aryal, Dipendra, Wetsel, William C., Mains, Richard E., Eipper, Betty A.

“…Copper (Cu), an essential trace element present throughout the mammalian nervous system, is crucial for normal synaptic function. Neuronal handling of Cu is…”
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Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl by Ma, Xin-Ming, Miller, Megan B, Vishwanatha, K S, Gross, Maegan J, Wang, Yanping, Abbott, Thomas, Lam, Tukiet T, Mains, Richard E, Eipper, Betty A

“…Like several Rho GDP/GTP exchange factors (GEFs), Kalirin7 (Kal7) contains an N-terminal Sec14 domain and multiple spectrin repeats. A natural splice variant…”
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Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity by Miller, Megan B, Yan, Yan, Machida, Kazuya, Kiraly, Drew D, Levy, Aaron D, Wu, Yi I, Lam, TuKiet T, Abbott, Thomas, Koleske, Anthony J, Eipper, Betty A, Mains, Richard E

“…Kalirin7 (Kal7), a postsynaptic Rho GDP/GTP exchange factor (RhoGEF), plays a crucial role in long-term potentiation and in the effects of cocaine on behavior…”
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Alternate promoter usage generates two subpopulations of the neuronal Rho GEF Kalirin‐7 by Miller, Megan B., Yan, Yan, Wu, Yi, Hao, Bing, Mains, Richard E., Eipper, Betty A.

“…Abstract Kalirin (Kal), a dual Rho GDP / GTP exchange factor ( GEF ), plays essential roles within and outside the nervous system. Tissue‐specific,…”
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Peptidylglycine [alpha]-amidating monooxygenase heterozygosity alters brain copper handling with region specificity by Gaier, Eric D, Miller, Megan B, Ralle, Martina, Aryal, Dipendra, Wetsel, William C, Mains, Richard E, Eipper, Betty A

“…Copper (Cu), an essential trace element present throughout the mammalian nervous system, is crucial for normal synaptic function. Neuronal handling of Cu is…”
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Pam (Peptidylglycine α-amidating monooxygenase) heterozygosity alters brain copper handling with region specificity by Gaier, Eric D, Miller, Megan B, Ralle, Martina, Aryal, Dipendra, Wetsel, William C, Mains, Richard E, Eipper, Betty A

“…Copper (Cu), an essential trace element present throughout the mammalian nervous system, is crucial for normal synaptic function. Neuronal handling of Cu is…”
Get full text

NMDA-Mediated Ca 2+ Influx Drives Aberrant Ryanodine Receptor Activation in Dendrites of Young Alzheimer's Disease Mice by Goussakov, Ivan, Miller, Megan B., Stutzmann, Grace E.

“…Deficits in synaptic function, particularly through NMDA receptors (NMDARs), are linked to late-stage cognitive impairments in Alzheimer's disease (AD). At…”
Get full text

Neuronal RhoGEFs in synaptic physiology and behavior by Miller, Megan B., Yan, Yan, Eipper, Betty A., Mains, Richard E.

“…In the mammalian brain the majority of excitatory synapses are housed in micron-sized dendritic protrusions called spines, which can undergo rapid changes in…”
Get full text

Stabilizing ER Ca.sup.2+ Channel Function as an Early Preventative Strategy for Alzheimer's Disease by Chakroborty, Shreaya, Briggs, Clark, Miller, Megan B, Goussakov, Ivan, Schneider, Corinne, Kim, Joyce, Wicks, Jaime, Richardson, Jill C, Conklin, Vincent, Cameransi, Benjamin G, Stutzmann, Grace E

“…Alzheimer's disease (AD) is a devastating neurodegenerative condition with no known cure. While current therapies target late-stage amyloid formation and…”
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Preventing preventable strokes: A study protocol to push guideline-driven atrial fibrillation patient education via patient portal by Fitzpatrick, Michael, Sadiq, Hammad, Rampam, Sanjeev, Araia, Almaz, Miller, Megan, Vargas, Kevin Rivera, Fry, Patrick, Smith, Anne Marie, Lowe, Mary Martin, Catalano, Christina, Harrison, Charles, Catanzaro, John, Crawford, Sybil, McManus, David, Kapoor, Alok

“…The main approach to preventing stroke in patients with atrial fibrillation (AF) is anticoagulation (AC), but only about 60% of at-risk individuals are on AC…”
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