Search Results - "Miller, Jordan D"

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span by Robbins, Paul D, Jurk, Diana, Khosla, Sundeep, Kirkland, James L, LeBrasseur, Nathan K, Miller, Jordan D, Passos, João F, Pignolo, Robert J, Tchkonia, Tamar, Niedernhofer, Laura J

“…Senescence is the consequence of a signaling mechanism activated in stressed cells to prevent proliferation of cells with damage. Senescent cells (Sncs) often…”
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Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms by Miller, Jordan D, Weiss, Robert M, Heistad, Donald D

“…Calcific aortic valve stenosis (CAVS) is a major health problem facing aging societies. The identification of osteoblast-like and osteoclast-like cells in…”
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Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice by Roos, Carolyn M., Zhang, Bin, Palmer, Allyson K., Ogrodnik, Mikolaj B., Pirtskhalava, Tamar, Thalji, Nassir M., Hagler, Michael, Jurk, Diana, Smith, Leslie A., Casaclang‐Verzosa, Grace, Zhu, Yi, Schafer, Marissa J., Tchkonia, Tamara, Kirkland, James L., Miller, Jordan D.

“…Summary While reports suggest a single dose of senolytics may improve vasomotor function, the structural and functional impact of long‐term senolytic treatment…”
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A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline by Tarragó, Mariana G., Chini, Claudia C.S., Kanamori, Karina S., Warner, Gina M., Caride, Ariel, de Oliveira, Guilherme C., Rud, Micaela, Samani, Adrienne, Hein, Kyaw Z., Huang, Runqing, Jurk, Diana, Cho, Dong Seong, Boslett, James J., Miller, Jordan D., Zweier, Jay L., Passos, João F., Doles, Jason D., Becherer, David J., Chini, Eduardo N.

“…Aging is characterized by the development of metabolic dysfunction and frailty. Recent studies show that a reduction in nicotinamide adenine dinucleotide…”
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Impact of Aortic Valve Calcification, as Measured by MDCT, on Survival in Patients With Aortic Stenosis by Clavel, Marie-Annick, DVM, PhD, Pibarot, Philippe, DVM, PhD, Messika-Zeitoun, David, MD, PhD, Capoulade, Romain, PhD, Malouf, Joseph, MD, Aggarwal, Shivani R., MBBS, Araoz, Phillip A., MD, Michelena, Hector I., MD, Cueff, Caroline, MD, Larose, Eric, MD, MSc, Miller, Jordan D., PhD, Vahanian, Alec, MD, Enriquez-Sarano, Maurice, MD

“…Abstract Background Aortic valve calcification (AVC) load measures lesion severity in aortic stenosis (AS) and is useful for diagnostic purposes. Whether AVC…”
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Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease by Schafer, Marissa J., Atkinson, Elizabeth J., Vanderboom, Patrick M., Kotajarvi, Brian, White, Thomas A., Moore, Matthew M., Bruce, Charles J., Greason, Kevin L., Suri, Rakesh M., Khosla, Sundeep, Miller, Jordan D., Bergen, H. Robert, LeBrasseur, Nathan K.

“…Growth and differentiation factor 11 (GDF11) is a transforming growth factor β superfamily member with a controversial role in aging processes. We have…”
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Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue by Schafer, Marissa J, White, Thomas A, Evans, Glenda, Tonne, Jason M, Verzosa, Grace C, Stout, Michael B, Mazula, Daniel L, Palmer, Allyson K, Baker, Darren J, Jensen, Michael D, Torbenson, Michael S, Miller, Jordan D, Ikeda, Yasuhiro, Tchkonia, Tamara, van Deursen, Jan M, Kirkland, James L, LeBrasseur, Nathan K

“…Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however,…”
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Dysregulation of Antioxidant Mechanisms Contributes to Increased Oxidative Stress in Calcific Aortic Valvular Stenosis in Humans by Miller, Jordan D., PhD, Chu, Yi, PhD, Brooks, Robert M., BS, Richenbacher, Wayne E., MD, Peña-Silva, Ricardo, MD, Heistad, Donald D., MD

“…Dysregulation of Antioxidant Mechanisms Contributes to Increased Oxidative Stress in Calcific Aortic Valvular Stenosis in Humans Jordan D. Miller, Yi Chu,…”
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Network Tomography for Understanding Phenotypic Presentations in Aortic Stenosis by Casaclang-Verzosa, Grace, Shrestha, Sirish, Khalil, Muhammad Jahanzeb, Cho, Jung Sun, Tokodi, Márton, Balla, Sudarshan, Alkhouli, Mohamad, Badhwar, Vinay, Narula, Jagat, Miller, Jordan D., Sengupta, Partho P.

“…This study sought to build a patient−patient similarity network using multiple features of left ventricular (LV) structure and function in patients with aortic…”
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Influences of Sex and Estrogen in Arterial and Valvular Calcification by Zhang, Bin, Miller, Virginia M, Miller, Jordan D

“…Vascular and cardiac valvular calcification was once considered to be a degenerative and end stage product in aging cardiovascular tissues. Over the past two…”
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Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca2+ Handling Dysfunction in Heart Failure by Zhang, Caimei, Chen, Biyi, Guo, Ang, Zhu, Yanqi, Miller, Jordan D, Gao, Shan, Yuan, Can, Kutschke, William, Zimmerman, Kathy, Weiss, Robert M, Wehrens, Xander H T, Hong, Jiang, Johnson, Frances L, Santana, Luis F, Anderson, Mark E, Song, Long-Sheng

“…BACKGROUND—Cardiac dysfunction in failing hearts of human patients and animal models is associated with both microtubule densification and transverse-tubule…”
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Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes by Guo, Ang, Hall, Duane, Zhang, Caimei, Peng, Tianqing, Miller, Jordan D., Kutschke, William, Grueter, Chad E., Johnson, Frances L., Lin, Richard Z., Song, Long-Sheng

“…Junctophilin-2 (JP2), a membrane-binding protein that provides a structural bridge between the plasmalemma and sarcoplasmic reticulum, is essential for precise…”
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Sex-related differences in calcific aortic stenosis: correlating clinical and echocardiographic characteristics and computed tomography aortic valve calcium score to excised aortic valve weight by Thaden, Jeremy J, Nkomo, Vuyisile T, Suri, Rakesh M, Maleszewski, Joseph J, Soderberg, Daniel J, Clavel, Marie-Annick, Pislaru, Sorin V, Malouf, Joseph F, Foley, Thomas A, Oh, Jae K, Miller, Jordan D, Edwards, William D, Enriquez-Sarano, Maurice

“…Calcific aortic valve stenosis (AS) is purportedly associated with less calcium burden in women than in men. We sought to examine sex-related differences and…”
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The Impact of Frailty on Patient-Centered Outcomes Following Aortic Valve Replacement by Kotajarvi, Brian R, Schafer, Marissa J, Atkinson, Elizabeth J, Traynor, Megan M, Bruce, Charles J, Greason, Kevin L, Suri, Rakesh M, Miller, Jordan D, LeBrasseur, Nathan K

“…Frailty confers risk for surgical morbidity and mortality. Whether patient-reported measures of health, well-being, or quality of life respond differently to…”
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Sirtuin 6 Protects Against Oxidative Stress and Vascular Dysfunction in Mice by Greiten, Lawrence E., Zhang, Bin, Roos, Carolyn M., Hagler, Michael, Jahns, Fritz-Patrick, Miller, Jordan D.

“…Objective: Sirtuin deacetylases are major regulators of organismal aging, and while depletion of sirtuin 6 (SIRT6) in mice results in a profound progeroid…”
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Senescent Cells: A Therapeutic Target in Cardiovascular Diseases by Suda, Masayoshi, Paul, Karl H, Minamino, Tohru, Miller, Jordan D, Lerman, Amir, Ellison-Hughes, Georgina M, Tchkonia, Tamar, Kirkland, James L

“…Senescent cell accumulation has been observed in age-associated diseases including cardiovascular diseases. Senescent cells lack proliferative capacity and…”
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Calcific aortic valve stenosis in old hypercholesterolemic mice by WEISS, Robert M, OHASHI, Masuo, MILLER, Jordan D, YOUNG, Stephen G, HEISTAD, Donald D

“…Hypercholesterolemia and old age are clinical risk factors for development of aortic valve stenosis, and hypercholesterolemia is a putative therapeutic target…”
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Left ventricular dysfunction after degenerative mitral valve repair: A question of better molecular targets or better surgical timing? by Miller, Jordan D., PhD, Suri, Rakesh M., MD, DPhil

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Spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice by Wakisaka, Yoshinobu, Chu, Yi, Miller, Jordan D, Rosenberg, Gary A, Heistad, Donald D

“…Oxidative stress and matrix metalloproteinases (MMPs) contribute to hemorrhagic transformation after ischemic stroke and brain injury after intracerebral…”
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High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver by Zhou, Dan, Hlady, Ryan A., Schafer, Marissa J., White, Thomas A., Liu, Chen, Choi, Jeong-Hyeon, Miller, Jordan D., Roberts, Lewis R., LeBrasseur, Nathan K., Robertson, Keith D.

“…High-fat diet consumption and sedentary lifestyle elevates risk for obesity, non-alcoholic fatty liver disease, and cancer. Exercise training conveys health…”
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