Search Results - "Miller, Hugh R.P"

Primary Antibody-Fab Fragment Complexes: A Flexible Alternative to Traditional Direct and Indirect Immunolabeling Techniques by Brown, Jeremy K, Pemberton, Alan D, Wright, Steven H, Miller, Hugh R.P

“…Immunolabeling with immune complexes of primary and secondary antibodies offers an attractive method for detecting and quantifying specific antigen. Primary…”
Get full text

Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta by French, Anne T., Knight, Pamela A., Smith, W. David, Brown, Jeremy K., Craig, Nicola M., Pate, Judith A., Miller, Hugh R.P., Pemberton, Alan D.

“…A novel intelectin molecule designated sheep intelectin 2 (sITLN2) was detected in sheep abomasal mucosa. The full sequence shared 76–83% homology with other…”
Get full text

Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse—High specificity indicates high substrate selectivity by Andersson, Mattias K., Pemberton, Alan D., Miller, Hugh R.P., Hellman, Lars

“…Mucosal mast cells are in the mouse predominantly found in the epithelium of the gastrointestinal tract. They express the β-chymases mMCP-1 and mMCP-2. During…”
Get full text

Expression of three intelectins in sheep and response to a Th2 environment by FRENCH, Anne T, KNIGHT, Pamela A, SMITH, W. David, PATE, Judith A, MILLER, Hugh R. P, PEMBERTON, Alan D

“…Sheep intelectin1 and sheep intelectin3 (sITLN1 and sITLN3) were cloned and sequenced. The amino acid sequences of sITLN1 and sITLN3 shared 86% and 91%…”
Get full text

Apical Junction Complex Protein Expression in the Canine Colon: Differential Expression of Claudin-2 in the Colonic Mucosa in Dogs With Idiopathic Colitis by Ridyard, Alison E, Brown, Jeremy K, Rhind, Susan M, Else, Roderick W, Simpson, James W, Miller, Hugh R.P

“…Canine idiopathic lymphocytic-plasmacytic colitis (LPC) is a well-recognized clinical and pathological entity in the dog, associated with altered immune cell…”
Get full text

The expression of intelectin in sheep goblet cells and upregulation by interleukin-4 by French, Anne T., Bethune, Julie A., Knight, Pamela A., McNeilly, Tom N., Wattegedera, Sean, Rhind, Susan, Miller, Hugh R.P., Pemberton, Alan D.

“…Upregulation of intelectin (ITLN) transcript and protein has previously been shown in intestinal nematode infections of resistant mice strains with…”
Get full text

Aberrant Mucosal Mast Cell Protease Expression in the Enteric Epithelium of Nematode-Infected Mice Lacking the Integrin αv β6 , a Transforming Growth Factor-β1 Activator by Knight, Pamela A, Brown, Jeremy K, Wright, Steven H, Thornton, Elisabeth M, Pate, Judith A, Miller, Hugh R.P

“…Infection of mice with the nematode Trichinella spiralis triggers recruitment and differentiation of intraepithelial intestinal mucosal mast cells expressing…”
Get full text

Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract by Owyang, Alexander M, Zaph, Colby, Wilson, Emma H, Guild, Katherine J, McClanahan, Terrill, Miller, Hugh R P, Cua, Daniel J, Goldschmidt, Michael, Hunter, Christopher A, Kastelein, Robert A, Artis, David

“…The cytokine interleukin (IL) 25 has been implicated in the initiation of type 2 immunity by driving the expression of type 2 cytokines such as IL-5 and IL-13,…”
Get full text

Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors by Weller, Charlotte L, Collington, Sarah J, Brown, Jeremy K, Miller, Hugh R P, Al-Kashi, Adam, Clark, Peter, Jose, Peter J, Hartnell, Adele, Williams, Timothy J

“…Mast cells are tissue-resident cells with important functions in allergy and inflammation. Pluripotential hematopoietic stem cells in the bone marrow give rise…”
Get full text

RELMβ/FIZZ2 Is a Goblet Cell-Specific Immune-Effector Molecule in the Gastrointestinal Tract by Artis, David, Wang, Mei Lun, Keilbaugh, Sue A., He, Weimian, Brenes, Mario, Swain, Gary P., Knight, Pamela A., Donaldson, Deborah D., Lazar, Mitchell A., Hugh R. P. Miller, Schad, Gerhard A., Scott, Phillip, Wu, Gary D., Metzger, Henry

“…Gastrointestinal (GI) nematode infections are an important public health and economic concern. Experimental studies have shown that resistance to infection…”
Get full text

Tissue‐specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut by Miller, Hugh R. P., Pemberton, Alan D.

“…Summary Serine proteinases with trypsin‐like (tryptase) and chymotrypsin‐like (chymase) properties are major constituents of mast cell granules. Several…”
Get full text

Mast Cells Disrupt Epithelial Barrier Function during Enteric Nematode Infection by McDermott, Jacqueline R., Bartram, Ruth E., Knight, Pamela A., Hugh R. P. Miller, Garrod, David R., Grencis, Richard K.

“…We have investigated the influence of mast cells on the barrier function of intestinal epithelium during nematode infection. Trichinella spiralis infection…”
Get full text

The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity by Artis, David, Villarino, Alejandro, Silverman, Michael, He, Weimian, Thornton, Elizabeth M, Mu, Sharon, Summer, Shamin, Covey, Todd M, Huang, Elaine, Yoshida, Hiroki, Koretzky, Gary, Goldschmidt, Michael, Wu, Gary D, de Sauvage, Fred, Miller, Hugh R. P, Saris, Christiaan J. M, Scott, Phillip, Hunter, Christopher A

“…Although previous studies have investigated the role of IL-27/WSX-1 interactions in the regulation of Th1 responses, little is known about their role in…”
Get full text

Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1 by Knight, P A, Wright, S H, Lawrence, C E, Paterson, Y Y, Miller, H R

“…Expulsion of gastrointestinal nematodes is associated with pronounced mucosal mast cell (MMC) hyperplasia, differentiation, and activation, accompanied by the…”
Get full text

Innate BALB/c Enteric Epithelial Responses to Trichinella spiralis: Inducible Expression of a Novel Goblet Cell Lectin, Intelectin-2, and Its Natural Deletion in C57BL/10 Mice by Pemberton, Alan D, Knight, Pamela A, Gamble, John, Colledge, William H, Lee, Jin-Kyu, Pierce, Michael, Miller, Hugh R. P

“…Infection of mice with the nematode parasite Trichinella spiralis induces changes in the proteome of the jejunal epithelium, including substantial…”
Get full text

Mouse mast cell protease-1 is required for the enteropathy induced by gastrointestinal helminth infection in the mouse by Lawrence, Catherine E., Paterson, Yvonne Y.W., Wright, Steven H., Knight, Pamela A., Miller, Hugh R.P.

“…Background & Aims: The relationship between intestinal pathology and immune expulsion of gastrointestinal nematodes remains controversial. Immune expulsion of…”
Get full text

A Novel Function for Transforming Growth Factor-β1: Upregulation of the Expression and the IgE-Independent Extracellular Release of a Mucosal Mast Cell Granule-Specific β-Chymase, Mouse Mast Cell Protease-1 by Miller, Hugh R.P., Wright, Steven H., Knight, Pamela A., Thornton, Elisabeth M.

“…Intestinal mucosal mast cells (IMMC) express granule neutral proteases that are regulated by T-cell–derived cytokines, including interleukin-3 (IL-3) and IL-9,…”
Get full text

Proteomic approach to identify candidate effector molecules during the in vitro immune exclusion of infective Teladorsagia circumcincta in the abomasum of sheep by Athanasiadou, Spiridoula, Pemberton, Alan, Jackson, Frank, Inglis, Neil, Miller, Hugh R P, Thévenod, Frank, Mackellar, Annie, Huntley, John F

“…In the present study we have employed an in vitro organ challenge model to study the post-challenge responses in parasite naïve and immune gastric tissue of…”
Get more information

Integrin-αvβ6, a Putative Receptor for Foot-and-Mouth Disease Virus, Is Constitutively Expressed in Ruminant Airways by Brown, Jeremy K., McAleese, Sybil M., Thornton, Elisabeth M., Pate, Judith A., Schock, Alexandra, Macrae, Alistair I., Scott, Philip R., Miller, Hugh R.P., Collie, David D.S.

“…Evolved functions of integrin-αvβ6 include roles in epithelial cell-extracellular matrix protein interactions and in the binding and activation of latent…”
Get full text

Proteomic analysis of mouse jejunal epithelium and its response to infection with the intestinal nematode, Trichinella spiralis by Pemberton, Alan D., Knight, Pamela A., Wright, Steven H., Miller, Hugh R. P.

“…Infection with the intestinal nematode Trichinella spiralis induces profound, but stereotypic pathological changes to the epithelium, which are common to many…”
Get full text