Search Results - "Miller, David D."

Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment by Hougaard, Charlotte, Jensen, Marianne L, Dale, Tim J, Miller, David D, Davies, David J, Eriksen, Birgitte L, Strøbaek, Dorte, Trezise, Derek J, Christophersen, Palle

“…A new small molecule, 4-(2-methoxy-phenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X), is presented as an activator of…”
Get more information

Polysubstituted Pyridazinones from Sequential Nucleophilic Substitution Reactions of Tetrafluoropyridazine by Pattison, Graham, Sandford, Graham, Yufit, Dmitry S, Howard, Judith A. K, Christopher, John A, Miller, David D

“…4,5,6-Trifluoropyridazin-3(2H)-one can be used as a scaffold for the synthesis of various 4,5- and 4,6-disubstituted and ring-fused pyridazinone systems by…”
Get full text

Transition from Micelles to Vesicles in Aqueous Mixtures of Anionic and Cationic Surfactants by Söderman, Olle, Herrington, Kathleen L, Kaler, Eric W, Miller, David D

“…Vesicles form spontaneously in a variety of aqueous mixtures of oppositely charged surfactants. Here we report the morphological transition from spherical…”
Get full text

Effect of the protease plasmin on C. elegans hyperactive DEG/ENaC channels MEC-4(d) and UNC-8(d) by Johnson, Christina K, Miller, David D, Bianchi, Laura

“…MEC-4 and UNC-8 belong to the DEG/ENaC family of voltage-independent Na channels and have been implicated in mechanosensation and synaptic remodeling. MEC-4…”
Get full text

9,10-Dioxa-1,2-diaza-anthracene derivatives from tetrafluoropyridazine by Pattison, Graham, Sandford, Graham, Yufit, Dmitrii S, Howard, Judith A K, Christopher, John A, Miller, David D

“…Reaction of tetrafluoropyridazine with catechol gives a tricyclic 9,10-dioxa-1,2-diaza-anthracene system by a sequential nucleophilic aromatic substitution…”
Get full text

Perhalogenated pyrimidine scaffolds. Reactions of 5-chloro-2,4,6-trifluoropyrimidine with nitrogen centred nucleophiles by Parks, Emma L, Sandford, Graham, Christopher, John A, Miller, David D

“…Highly functionalised pyrimidine derivatives are of great importance to the life-science industries and there exists a need for efficient synthetic methodology…”
Get full text

Combined application of organozinc chemistry and one-pot hydroboration-Suzuki coupling to the synthesis of amino acids by Rodríguez, Arantxa, Miller, David D, Jackson, Richard F

“…Hydroboration using 9-BBN-H of the protected enantiomerically pure but-3-enylglycine derivative 11, prepared by copper-catalysed allylation of the…”
Get more information

Display of Arms: A Roundtable Discussion about the Public Exhibition of Firearms and Their History by Tucker, Jennifer, Adamson, Glenn, Ferguson, Jonathan S, Garrett-Davis, Josh, Goldstein, Erik, Hlebinsky, Ashley, Miller, David D, Slavick, Susanne

“…In this roundtable moderated by historian of technology Jennifer Tucker, museum and art exhibition curators reflect on the meanings, significance, and…”
Get full text

Dipyrido[1,2- a;3′,4′- d]imidazole systems by Cartwright, Matthew W., Convery, Laura, Kraynck, Thomas, Sandford, Graham, Yufit, Dmitrii S., Howard, Judith A.K., Christopher, John A., Miller, David D.

“…Novel tricyclic dipyridoimidazole derivatives can be readily synthesised in one pot processes from various highly fluorinated pyridine systems such as…”
Get full text

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent by Kerns, Jeffrey K, Busch-Petersen, Jakob, Fu, Wei, Boehm, Jeffrey C, Nie, Hong, Muratore, Michael, Bullion, Ann, Lin, Guoliang, Li, Huijie, Davis, Roderick, Lin, Xichen, Lakdawala, Ami S, Cousins, Rick, Field, Rita, Payne, Jeremy, Miller, David D, Bamborough, Paul, Christopher, John A, Baldwin, Ian, Osborn, Ruth R, Yonchuk, John, Webb, Edward, Rumsey, William L

“…IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the…”
Get full text

Annelation of perfluorinated heteroaromatic systems by 1,3-dicarbonyl derivatives by Cartwright, Matthew W., Parks, Emma L., Pattison, Graham, Slater, Rachel, Sandford, Graham, Wilson, Ian, Yufit, Dmitrii S., Howard, Judith A.K., Christopher, John A., Miller, David D.

“…Reactions of various perfluorinated heteroaromatic substrates such as tetrafluoro-4-cyanopyridine, tetrafluoropyrazine and tetrafluoropyridazine with…”
Get full text

Errors in 'Trials and error' by Miller, David D

“…A letter to the editor regarding errors in an article is presented…”
Get full text

Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IκB Kinase-β (IKK-β) by Christopher, John A, Bamborough, Paul, Alder, Catherine, Campbell, Amanda, Cutler, Geoffrey J, Down, Kenneth, Hamadi, Ahmed M, Jolly, Adrian M, Kerns, Jeffrey K, Lucas, Fiona S, Mellor, Geoffrey W, Miller, David D, Morse, Mary A, Pancholi, Kiritkant D, Rumsey, William, Solanke, Yemisi E, Williamson, Rick

“…The identification and progression of a potent and selective series of isoquinoline inhibitors of IκB kinase-β (IKK-β) are described. Hit-generation chemistry…”
Get full text

Imidazopyridine and pyrimidinopyridine systems from perfluorinated pyridine derivatives by Cartwright, Matthew W., Sandford, Graham, Bousbaa, Jamaal, Yufit, Dmitrii S., Howard, Judith A.K., Christopher, John A., Miller, David D.

“…Annelation of pentafluoropyridine via an intramolecular nucleophilic aromatic substitution process with benzamidine gave an imidazopyridine system in high…”
Get full text

The discovery and initial optimisation of pyrrole-2-carboxamides as inhibitors of p38α MAP kinase by Down, Kenneth, Bamborough, Paul, Alder, Catherine, Campbell, Amanda, Christopher, John A., Gerelle, Maria, Ludbrook, Steve, Mallett, Dave, Mellor, Geoff, Miller, David D., Pearson, Rosannah, Ray, Keith, Solanke, Yemisi, Somers, Don

“…A novel pyrrole-2-carboxamide series of p38α inhibitors, discovered through the application of virtual screening, is presented. A novel pyrrole-2-carboxamide…”
Get full text

3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β by Miller, David D., Bamborough, Paul, Christopher, John A., Baldwin, Ian R., Champigny, Aurelie C., Cutler, Geoffrey J., Kerns, Jeffrey K., Longstaff, Timothy, Mellor, Geoffrey W., Morey, James V., Morse, Mary A., Nie, Hong, Rumsey, William L., Taggart, John J.

“…The discovery and hit-to-lead exploration of a novel series of selective IKK-β kinase inhibitors is described. The initial lead fragment 3 was identified by…”
Get full text

A novel series of benzimidazole NR2B-selective NMDA receptor antagonists by Davies, David J., Crowe, Matthew, Lucas, Nolwenn, Quinn, Joanna, Miller, David D., Pritchard, Sara, Grose, David, Bettini, Ezio, Calcinaghi, Novella, Virginio, Caterina, Abberley, Lee, Goldsmith, Paul, Michel, Anton D., Chessell, Iain P., Kew, James N.C., Miller, Neil D., Gunthorpe, Martin J.

“…Discovery of a novel series of benzimidazole-derived NR2B selective NMDA receptor antagonists is described. A series of novel benzimidazoles are discussed as…”
Get full text

Out-of-Hospital Chest Escharotomy: A Case Series and Procedure Review by Kupas, Douglas F., Miller, David D.

“…Abstract Initial care for the burned trauma patient focuses on the rapid assessment and stabilization of airway, breathing, and circulation. Circumferential…”
Get full text

Trisubstituted pyrimidine derivatives from tetrafluoropyrimidine by Parks, Emma L., Sandford, Graham, Yufit, Dmitry S., Howard, Judith A.K., Christopher, John A., Miller, David D.

“…The use of tetrafluoropyrimidine as a scaffold for the synthesis of 2,4,6-trisubstituted pyrimidine derivatives by three sequential nucleophilic aromatic…”
Get full text

N-Functionalised polyfluoropyridazin-3(2 H)-one derivatives by Pattison, Graham, Sandford, Graham, Yufit, Dmitry S., Howard, Judith A.K., Christopher, John A., Miller, David D.

“…Pyridazin-3(2 H)-one systems have very useful biological properties and have found many applications within the pharmaceutical and agrochemical industries but,…”
Get full text