Search Results - "Miller, DW"

A fluorometric screening assay for drug efflux transporter activity in the blood-brain barrier by Bachmeier, Corbin J, Miller, Donald W

“…To examine the capability of a fluorometric assay to identify and characterize the drug efflux interactions of a broad spectrum of drug agents in an in vitro…”
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Seasonal and dose-dependent effects of intracerebroventricular leptin on lh secretion and appetite in sheep by Miller, DW, Findlay, PA, Morrison, MA, Raver, N, Adam, CL

“…The role of leptin in neuroendocrine appetite and reproductive regulation remains to be fully resolved. A series of three experiments was conducted using…”
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Novel ADMET design tool for chemists by Miller, DW, Fraczkiewicz, R, Woltosz, WS

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Lipid Nanoparticle-Based Inhibitors for SARS-CoV-2 Host Cell Infection by Yathindranath, Vinith, Safa, Nura, Tomczyk, Mateusz Marek, Dolinsky, Vernon, Miller, Donald W

“…The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lingering threat to public health has fueled the search for…”
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Comparison of Conventional-Dose vs High-Dose Conformal Radiation Therapy in Clinically Localized Adenocarcinoma of the Prostate: A Randomized Controlled Trial by Zietman, Anthony L, DeSilvio, Michelle L, Slater, Jerry D, Rossi, Carl J, Miller, Daniel W, Adams, Judith A, Shipley, William U

“…CONTEXT Clinically localized prostate cancer is very prevalent among US men, but recurrence after treatment with conventional radiation therapy is common…”
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Effect of maternal undernutrition during pregnancy on early ovarian development and subsequent follicular development in sheep fetuses by Rae, MT, Palassio, S, Kyle, CE, Brooks, AN, Lea, RG, Miller, DW, Rhind, SM

“…Gonad development in female sheep fetuses is thought to occur in a number of key stages. The aim of this study was to determine the effects of maternal…”
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Solution Structures of Human LL-37 Fragments and NMR-Based Identification of a Minimal Membrane-Targeting Antimicrobial and Anticancer Region by Li, Xia, Li, Yifeng, Han, Huiyun, Miller, Donald W, Wang, Guangshun

“…To understand the structure and activity relationship of human LL-37, a series of peptide fragments was designed. The N-terminal fragment, LL-37(1−12), was not…”
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Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models by Sun, Zhizhi, Yathindranath, Vinith, Worden, Matthew, Thliveris, James A, Chu, Stephanie, Parkinson, Fiona E, Hegmann, Torsten, Miller, Donald W

“…Aminosilane-coated iron oxide nanoparticles (AmS-IONPs) have been widely used in constructing complex and multifunctional drug delivery systems. However, the…”
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Magnetic field enhanced convective diffusion of iron oxide nanoparticles in an osmotically disrupted cell culture model of the blood-brain barrier by Sun, Zhizhi, Worden, Matthew, Wroczynskyj, Yaroslav, Yathindranath, Vinith, van Lierop, Johan, Hegmann, Torsten, Miller, Donald W

“…The present study examines the use of an external magnetic field in combination with the disruption of tight junctions to enhance the permeability of iron…”
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The Parkinson's Disease Protein DJ-1 Is Neuroprotective Due to Cysteine-Sulfinic Acid-Driven Mitochondrial Localization by Canet-Avilés, Rosa M., Wilson, Mark A., Miller, David W., Ahmad, Rili, McLendon, Chris, Bandyopadhyay, Sourav, Baptista, Melisa J., Ringe, Dagmar, Petsko, Gregory A., Cookson, Mark R.

“…Loss-of-function DJ-1 mutations can cause early-onset Parkinson's disease. The function of DJ-1 is unknown, but an acidic isoform accumulates after oxidative…”
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Crohn’s Disease Patients’ Risk-Benefit Preferences: Serious Adverse Event Risks Versus Treatment Efficacy by Johnson, F. Reed, Özdemir, Semra, Mansfield, Carol, Hass, Steven, Miller, David W, Siegel, Corey A, Sands, Bruce E

“…Background & Aims: Regulatory assessments of drug risks do not routinely consider patient preferences, despite evidence that some patients are willing to…”
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Mutations in PTEN-Induced Putative Kinase 1 Associated with Recessive Parkinsonism Have Differential Effects on Protein Stability by Beilina, Alexandra, Van Der Brug, Marcel, Ahmad, Rili, Kesavapany, Sashi, Miller, David W., Petsko, Gregory A., Cookson, Mark R.

“…Several mutations in PTEN-induced putative kinase 1 (PINK1) gene have been reported to be associated with recessive parkinsonism. The encoded protein is…”
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Pluronic ® block copolymers as modulators of drug efflux transporter activity in the blood–brain barrier by Kabanov, Alexander V., Batrakova, Elena V., Miller, Donald W.

“…Drug efflux transporters can influence the absorption, tissue distribution and elimination of many therapeutic agents. Modulation of drug efflux transporter…”
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α-Synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication by MILLER, D. W, HAGUE, S. M, CLARIMON, J, BAPTISTA, M, GWINN-HARDY, K, COOKSON, M. R, SINGLETON, A. B

“…The authors recently demonstrated that genetic triplication of the SNCA locus causes Parkinson disease. Here it is shown that SNCA triplication results in a…”
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Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1 by Sandebring, Anna, Thomas, Kelly Jean, Beilina, Alexandra, van der Brug, Marcel, Cleland, Megan M, Ahmad, Rili, Miller, David W, Zambrano, Ibardo, Cowburn, Richard F, Behbahani, Homira, Cedazo-Mínguez, Angel, Cookson, Mark R

“…PTEN-induced novel kinase 1 (PINK1) mutations are associated with autosomal recessive parkinsonism. Previous studies have shown that PINK1 influences both…”
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First results from the CERN axion solar telescope by Zioutas, K, Andriamonje, S, Arsov, V, Aune, S, Autiero, D, Avignone, F T, Barth, K, Belov, A, Beltrán, B, Bräuninger, H, Carmona, J M, Cebrián, S, Chesi, E, Collar, J I, Creswick, R, Dafni, T, Davenport, M, Di Lella, L, Eleftheriadis, C, Englhauser, J, Fanourakis, G, Farach, H, Ferrer, E, Fischer, H, Franz, J, Friedrich, P, Geralis, T, Giomataris, I, Gninenko, S, Goloubev, N, Hasinoff, M D, Heinsius, F H, Hoffmann, D H H, Irastorza, I G, Jacoby, J, Kang, D, Königsmann, K, Kotthaus, R, Krcmar, M, Kousouris, K, Kuster, M, Lakić, B, Lasseur, C, Liolios, A, Ljubicić, A, Lutz, G, Luzón, G, Miller, D W, Morales, A, Morales, J, Mutterer, M, Nikolaidis, A, Ortiz, A, Papaevangelou, T, Placci, A, Raffelt, G, Ruz, J, Riege, H, Sarsa, M L, Savvidis, I, Serber, W, Serpico, P, Semertzidis, Y, Stewart, L, Vieira, J D, Villar, J, Walckiers, L, Zachariadou, K

“…Hypothetical axionlike particles with a two-photon interaction would be produced in the sun by the Primakoff process. In a laboratory magnetic field ("axion…”
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Maternal undernutrition alters triiodothyronine concentrations and pituitary response to GnRH in fetal sheep by Rae, MT, Rhind, SM, Kyle, CE, Miller, DW, Brooks, AN

“…The aims of this study were to determine which hormones may have a role in the expression of maternal undernutrition effects on reproductive function, in both…”
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Effect of maternal undernutrition on fetal testicular steroidogenesis during the CNS androgen-responsive period in male sheep fetuses by Rae, MT, Rhind, SM, Fowler, PA, Miller, DW, Kyle, CE, Brooks, AN

“…The aim of this study was to determine the effects of maternal undernutrition, applied during physiologically relevant stages of development of the…”
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Ethanol-Induced Activation of Myosin Light Chain Kinase Leads to Dysfunction of Tight Junctions and Blood-Brain Barrier Compromise by Haorah, James, Heilman, David, Knipe, Bryan, Chrastil, Jesse, Leibhart, Jessica, Ghorpade, Anuja, Miller, Donald W., Persidsky, Yuri

“…Background: Brain endothelial cells form the blood‐brain barrier (BBB) that regulates solute and macromolecule flux in and out of the brain, leukocyte…”
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The expression of DJ‐1 (PARK7) in normal human CNS and idiopathic Parkinson’s disease by Bandopadhyay, Rina, Kingsbury, Ann E., Cookson, Mark R., Reid, Andrew R., Evans, Ian M., Hope, Andrew D., Pittman, Alan M., Lashley, Tammaryn, Canet‐Aviles, Rosa, Miller, David W., McLendon, Chris, Strand, Catherine, Leonard, Andrew J., Abou‐Sleiman, Patrick M., Healy, Daniel G., Ariga, Hiroyashi, Wood, Nicholas W., de Silva, Rohan, Revesz, Tamas, Hardy, John A., Lees, Andrew J.

“…Two mutations in the DJ‐1 gene on chromosome1p36 have been identified recently to cause early‐onset, autosomal recessive Parkinson’s disease. As no information…”
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