Search Results - "Miller, Brittany K."

Efficacy of pyrazinoic acid dry powder aerosols in resolving necrotic and non-necrotic granulomas in a guinea pig model of tuberculosis by Montgomery, Stephanie A, Young, Ellen F, Durham, Phillip G, Zulauf, Katelyn E, Rank, Laura, Miller, Brittany K, Hayden, Jennifer D, Lin, Feng-Chang, Welch, John T, Hickey, Anthony J, Braunstein, Miriam

“…New therapeutic strategies are needed to treat drug resistant tuberculosis (TB) and to improve treatment for drug sensitive TB. Pyrazinamide (PZA) is a…”
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Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway by Miller, Brittany K, Hughes, Ryan, Ligon, Lauren S, Rigel, Nathan W, Malik, Seidu, Anjuwon-Foster, Brandon R, Sacchettini, James C, Braunstein, Miriam

“…The SecA2 protein export system is critical for the virulence of . However, the mechanism of this export pathway remains unclear. Through a screen for…”
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Allosteric regulation of exocyst: Discrete activation of tethering by two spatial signals by Miller, Brittany K, Rossi, Guendalina, Hudson, Sara, Cully, David, Baker, Richard W, Brennwald, Patrick

“…The exocyst imparts spatial control during exocytic vesicle tethering through its interactions with proteins and lipids on the vesicle and the plasma membrane…”
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Pharmacokinetic Considerations for Optimizing Inhaled Spray-Dried Pyrazinoic Acid Formulations by Yeshwante, Shekhar B., Hanafin, Patrick, Miller, Brittany K., Rank, Laura, Murcia, Sebastian, Xander, Christian, Annis, Ayano, Baxter, Victoria K., Anderson, Elizabeth J., Jermain, Brian, Konicki, Robyn, Schmalstig, Alan A., Stewart, Ian, Braunstein, Miriam, Hickey, Anthony J., Rao, Gauri G.

“…Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of death with 1.6 million deaths worldwide reported in 2021. Oral…”
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An orphaned Mce‐associated membrane protein of Mycobacterium tuberculosis is a virulence factor that stabilizes Mce transporters by Perkowski, Ellen Foot, Miller, Brittany K., McCann, Jessica R., Sullivan, Jonathan Tabb, Malik, Seidu, Allen, Irving Coy, Godfrey, Virginia, Hayden, Jennifer D., Braunstein, Miriam

“…Summary Mycobacterium tuberculosis proteins that are exported out of the bacterial cytoplasm are ideally positioned to be virulence factors; however, the…”
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Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2 by Swanson, Stephanie, Ioerger, Thomas R, Rigel, Nathan W, Miller, Brittany K, Braunstein, Miriam, Sacchettini, James C

“…While SecA is the ATPase component of the major bacterial secretory (Sec) system, mycobacteria and some Gram-positive pathogens have a second paralog, SecA2…”
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The Sec Pathways and Exportomes of Mycobacterium tuberculosis by Miller, Brittany K, Zulauf, Katelyn E, Braunstein, Miriam

“…All bacteria utilize pathways to export proteins from the cytoplasm to the bacterial cell envelope or extracellular space. Many exported proteins function in…”
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VBP15, a novel anti‐inflammatory and membrane‐stabilizer, improves muscular dystrophy without side effects by Heier, Christopher R., Damsker, Jesse M., Yu, Qing, Dillingham, Blythe C., Huynh, Tony, Van der Meulen, Jack H., Sali, Arpana, Miller, Brittany K., Phadke, Aditi, Scheffer, Luana, Quinn, James, Tatem, Kathleen, Jordan, Sarah, Dadgar, Sherry, Rodriguez, Olga C., Albanese, Chris, Calhoun, Michael, Gordish‐Dressman, Heather, Jaiswal, Jyoti K., Connor, Edward M., McCall, John M., Hoffman, Eric P., Reeves, Erica K. M., Nagaraju, Kanneboyina

“…Absence of dystrophin makes skeletal muscle more susceptible to injury, resulting in breaches of the plasma membrane and chronic inflammation in Duchenne…”
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Long-term treatment with naproxcinod significantly improves skeletal and cardiac disease phenotype in the mdx mouse model of dystrophy by Uaesoontrachoon, Kitipong, Quinn, James L, Tatem, Kathleen S, Van Der Meulen, Jack H, Yu, Qing, Phadke, Aditi, Miller, Brittany K, Gordish-Dressman, Heather, Ongini, Ennio, Miglietta, Daniela, Nagaraju, Kanneboyina

“…In Duchenne muscular dystrophy (DMD) patients and the mouse model of DMD, mdx, dystrophin deficiency causes a decrease and mislocalization of muscle-specific…”
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An orphaned M ce‐associated membrane protein of M ycobacterium tuberculosis is a virulence factor that stabilizes M ce transporters by Perkowski, Ellen Foot, Miller, Brittany K., McCann, Jessica R., Sullivan, Jonathan Tabb, Malik, Seidu, Allen, Irving Coy, Godfrey, Virginia, Hayden, Jennifer D., Braunstein, Miriam

“…Mycobacterium tuberculosis proteins that are exported out of the bacterial cytoplasm are ideally positioned to be virulence factors; however, the functions of…”
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