Search Results - "Millard, J"

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates by Millard, Christopher J., Watson, Peter J., Celardo, Ivana, Gordiyenko, Yuliya, Cowley, Shaun M., Robinson, Carol V., Fairall, Louise, Schwabe, John W.R.

“…Class I histone deacetylases (HDAC1, HDAC2, and HDAC3) are recruited by cognate corepressor proteins into specific transcriptional repression complexes that…”
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PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes by Smalley, Joshua P, Adams, Grace E, Millard, Christopher J, Song, Yun, Norris, James K S, Schwabe, John W R, Cowley, Shaun Michael, Hodgkinson, James T

“…We have identified a proteolysis targeting chimera (PROTAC) of class I HDACs 1, 2 and 3. The most active degrader consists of a benzamide HDAC inhibitor, an…”
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Insights into the activation mechanism of class I HDAC complexes by inositol phosphates by Watson, Peter J., Millard, Christopher J., Riley, Andrew M., Robertson, Naomi S., Wright, Lyndsey C., Godage, Himali Y., Cowley, Shaun M., Jamieson, Andrew G., Potter, Barry V. L., Schwabe, John W. R.

“…Histone deacetylases (HDACs) 1, 2 and 3 form the catalytic subunit of several large transcriptional repression complexes. Unexpectedly, the enzymatic activity…”
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genetic architecture of maize height by Peiffer, Jason A, Romay, Maria C, Gore, Michael A, Flint-Garcia, Sherry A, Zhang, Zhiwu, Millard, Mark J, Gardner, Candice A. C, McCullen, Michael D, Holland, James B, Bradbury, Peter J, Buckler, Edward S

“…Height is one of the most heritable and easily measured traits in maize (Zea mays L.). Given a pedigree or estimates of the genomic identity-by-state (IBS)…”
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The 3D X-Ray Ejecta Structure of Tycho's Supernova Remnant by Millard, Matthew J., Park, Sangwook, Sato, Toshiki, Hughes, John P., Slane, Patrick, Patnaude, Daniel, Burrows, David, Badenes, Carles

“…Abstract We present our velocity measurements of 59 clumpy, metal-rich ejecta knots in the supernova remnant (SNR) of SN 1572 (Tycho). We use our 450 ks…”
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Conservation status of the American horseshoe crab, (Limulus polyphemus): a regional assessment by Smith, David R., Brockmann, H. Jane, Beekey, Mark A., King, Timothy L., Millard, Michael J., Zaldívar-Rae, Jaime

“…Horseshoe crabs have persisted for more than 200 million years, and fossil forms date to 450 million years ago. The American horseshoe crab ( Limulus…”
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The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure by Turnbull, Robert E., Fairall, Louise, Saleh, Almutasem, Kelsall, Emma, Morris, Kyle L., Ragan, T. J., Savva, Christos G., Chandru, Aditya, Millard, Christopher J., Makarova, Olga V., Smith, Corinne J., Roseman, Alan M., Fry, Andrew M., Cowley, Shaun M., Schwabe, John W. R.

“…MiDAC is one of seven distinct, large multi-protein complexes that recruit class I histone deacetylases to the genome to regulate gene expression. Despite…”
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A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes by Zhang, Tianyi, Wei, Guifeng, Millard, Christopher J., Fischer, Roman, Konietzny, Rebecca, Kessler, Benedikt M., Schwabe, John W. R., Brockdorff, Neil

“…Transcriptional regulation by chromatin is a highly dynamic process directed through the recruitment and coordinated action of epigenetic modifiers and readers…”
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Modeling Virus-Induced Inflammation in Zebrafish: A Balance Between Infection Control and Excessive Inflammation by Sullivan, Con, Soos, Brandy-Lee, Millard, Paul J, Kim, Carol H, King, Benjamin L

“…The inflammatory response to viral infection in humans is a dynamic process with complex cell interactions that are governed by the immune system and…”
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Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells by Jamaladdin, Shereen, Kelly, Richard D. W., O'Regan, Laura, Dovey, Oliver M., Hodson, Grace E., Millard, Christopher J., Portolano, Nicola, Fry, Andrew M., Schwabe, John W. R., Cowley, Shaun M.

“…Histone deacetylases 1 and 2 (HDAC1/2) form the core catalytic components of corepressor complexes that modulate gene expression. In most cell types, deletion…”
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Differential activation of NF‐κB and gene expression in oral epithelial cells by periodontal pathogens by Milward, M. R., Chapple, I. L. C., Wright, H. J., Millard, J. L., Matthews, J. B., Cooper, P. R.

“…Summary To investigate the molecular effects of the periodontopathogens Fusobacterium nucleatum (FN) and Porphyromonas gingivalis (PG) on the oral epithelium,…”
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Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: The N-Terminal Region of CCR3 Bound to CCL11/Eotaxin-1 by Millard, Christopher J., Ludeman, Justin P., Canals, Meritxell, Bridgford, Jessica L., Hinds, Mark G., Clayton, Daniel J., Christopoulos, Arthur, Payne, Richard J., Stone, Martin J.

“…Trafficking of leukocytes in immune surveillance and inflammatory responses is activated by chemokines engaging their receptors. Sulfation of tyrosine residues…”
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The structure of the core NuRD repression complex provides insights into its interaction with chromatin by Millard, Christopher J, Varma, Niranjan, Saleh, Almutasem, Morris, Kyle, Watson, Peter J, Bottrill, Andrew R, Fairall, Louise, Smith, Corinne J, Schwabe, John W R

“…The NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities. The…”
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Prenatal methadone exposure impairs adolescent cognition and GABAergic neurodevelopment in a novel rat model of maternal methadone treatment by Lum, Jeremy S., Bird, Katrina M., Wilkie, Jennifer, Millard, Samuel J., Pallimulla, Sachie, Newell, Kelly A., Wright, Ian M.

“…Methadone maintenance treatment (MMT) is the most common treatment for opioid-dependent pregnant women worldwide. Despite its widespread use, MMT is associated…”
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Diverse nucleosome Site-Selectivity among histone deacetylase complexes by Wang, Zhipeng A, Millard, Christopher J, Lin, Chia-Liang, Gurnett, Jennifer E, Wu, Mingxuan, Lee, Kwangwoon, Fairall, Louise, Schwabe, John Wr, Cole, Philip A

“…Histone acetylation regulates chromatin structure and gene expression and is removed by histone deacetylases (HDACs). HDACs are commonly found in various…”
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An evolving understanding of nuclear receptor coregulator proteins by Millard, Christopher J, Watson, Peter J, Fairall, Louise, Schwabe, John W R

“…Nuclear receptors are transcription factors that regulate gene expression through the ligand-controlled recruitment of a diverse group of proteins known as…”
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Hepatotoxicity Observed in Clinical Trials of Aplaviroc (GW873140) by NICHOLS, W. G, STEEL, H. M, BONNY, T, ADKISON, K, CURTIS, L, MILLARD, J, KABEYA, K, CLUMECK, N

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting by Itoh, Toshimasa, Fairall, Louise, Muskett, Frederick W, Milano, Charles P, Watson, Peter J, Arnaudo, Nadia, Saleh, Almutasem, Millard, Christopher J, El-Mezgueldi, Mohammed, Martino, Fabrizio, Schwabe, John W R

“…Recent proteomic studies have identified a novel histone deacetylase complex that is upregulated during mitosis and is associated with cyclin A. This complex…”
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The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor by Zhang, Li, Fairall, Louise, Goult, Benjamin T, Calkin, Anna C, Hong, Cynthia, Millard, Christopher J, Tontonoz, Peter, Schwabe, John W R

“…We previously identified the E3 ubiquitin ligase IDOL as a sterol-dependent regulator of the LDL receptor (LDLR). The molecular pathway underlying IDOL action,…”
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Primary synovial chondromatosis: an elemental investigation of a rare skeletal pathology by Beger, A. W., Millard, J. A., Bresnehan, A., Dudzik, B., Kunigelis, S.

“…BACKGROUND: Primary synovial chondromatosis (PSC) is a rare idiopathic pathology characterised by the formation of osseocartilaginous nodules within synovial…”
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