Search Results - "Millard, Christopher"

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates by Millard, Christopher J., Watson, Peter J., Celardo, Ivana, Gordiyenko, Yuliya, Cowley, Shaun M., Robinson, Carol V., Fairall, Louise, Schwabe, John W.R.

“…Class I histone deacetylases (HDAC1, HDAC2, and HDAC3) are recruited by cognate corepressor proteins into specific transcriptional repression complexes that…”
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Targeting Class I Histone Deacetylases in a “Complex” Environment by Millard, Christopher J, Watson, Peter J, Fairall, Louise, Schwabe, John W.R

“…Histone deacetylase (HDAC) inhibitors are proven anticancer therapeutics and have potential in the treatment of many other diseases including HIV infection,…”
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PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes by Smalley, Joshua P, Adams, Grace E, Millard, Christopher J, Song, Yun, Norris, James K S, Schwabe, John W R, Cowley, Shaun Michael, Hodgkinson, James T

“…We have identified a proteolysis targeting chimera (PROTAC) of class I HDACs 1, 2 and 3. The most active degrader consists of a benzamide HDAC inhibitor, an…”
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Insights into the activation mechanism of class I HDAC complexes by inositol phosphates by Watson, Peter J., Millard, Christopher J., Riley, Andrew M., Robertson, Naomi S., Wright, Lyndsey C., Godage, Himali Y., Cowley, Shaun M., Jamieson, Andrew G., Potter, Barry V. L., Schwabe, John W. R.

“…Histone deacetylases (HDACs) 1, 2 and 3 form the catalytic subunit of several large transcriptional repression complexes. Unexpectedly, the enzymatic activity…”
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The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure by Turnbull, Robert E., Fairall, Louise, Saleh, Almutasem, Kelsall, Emma, Morris, Kyle L., Ragan, T. J., Savva, Christos G., Chandru, Aditya, Millard, Christopher J., Makarova, Olga V., Smith, Corinne J., Roseman, Alan M., Fry, Andrew M., Cowley, Shaun M., Schwabe, John W. R.

“…MiDAC is one of seven distinct, large multi-protein complexes that recruit class I histone deacetylases to the genome to regulate gene expression. Despite…”
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A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes by Zhang, Tianyi, Wei, Guifeng, Millard, Christopher J., Fischer, Roman, Konietzny, Rebecca, Kessler, Benedikt M., Schwabe, John W. R., Brockdorff, Neil

“…Transcriptional regulation by chromatin is a highly dynamic process directed through the recruitment and coordinated action of epigenetic modifiers and readers…”
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Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: The N-Terminal Region of CCR3 Bound to CCL11/Eotaxin-1 by Millard, Christopher J., Ludeman, Justin P., Canals, Meritxell, Bridgford, Jessica L., Hinds, Mark G., Clayton, Daniel J., Christopoulos, Arthur, Payne, Richard J., Stone, Martin J.

“…Trafficking of leukocytes in immune surveillance and inflammatory responses is activated by chemokines engaging their receptors. Sulfation of tyrosine residues…”
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THE NEW THINGS: PROPERTY RIGHTS IN DIGITAL FILES? by Michels, Johan David, Millard, Christopher

“…This paper looks at the property status of digital files, such as electronic documents, under English law. We argue that, while mere information is rightly not…”
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The topology of chromatin-binding domains in the NuRD deacetylase complex by Millard, Christopher J, Fairall, Louise, Ragan, Timothy J, Savva, Christos G, Schwabe, John W R

“…Abstract Class I histone deacetylase complexes play essential roles in many nuclear processes. Whilst they contain a common catalytic subunit, they have…”
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Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells by Jamaladdin, Shereen, Kelly, Richard D. W., O'Regan, Laura, Dovey, Oliver M., Hodson, Grace E., Millard, Christopher J., Portolano, Nicola, Fry, Andrew M., Schwabe, John W. R., Cowley, Shaun M.

“…Histone deacetylases 1 and 2 (HDAC1/2) form the core catalytic components of corepressor complexes that modulate gene expression. In most cell types, deletion…”
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The structure of the core NuRD repression complex provides insights into its interaction with chromatin by Millard, Christopher J, Varma, Niranjan, Saleh, Almutasem, Morris, Kyle, Watson, Peter J, Bottrill, Andrew R, Fairall, Louise, Smith, Corinne J, Schwabe, John W R

“…The NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities. The…”
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Diverse nucleosome Site-Selectivity among histone deacetylase complexes by Wang, Zhipeng A, Millard, Christopher J, Lin, Chia-Liang, Gurnett, Jennifer E, Wu, Mingxuan, Lee, Kwangwoon, Fairall, Louise, Schwabe, John Wr, Cole, Philip A

“…Histone acetylation regulates chromatin structure and gene expression and is removed by histone deacetylases (HDACs). HDACs are commonly found in various…”
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An evolving understanding of nuclear receptor coregulator proteins by Millard, Christopher J, Watson, Peter J, Fairall, Louise, Schwabe, John W R

“…Nuclear receptors are transcription factors that regulate gene expression through the ligand-controlled recruitment of a diverse group of proteins known as…”
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Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting by Itoh, Toshimasa, Fairall, Louise, Muskett, Frederick W, Milano, Charles P, Watson, Peter J, Arnaudo, Nadia, Saleh, Almutasem, Millard, Christopher J, El-Mezgueldi, Mohammed, Martino, Fabrizio, Schwabe, John W R

“…Recent proteomic studies have identified a novel histone deacetylase complex that is upregulated during mitosis and is associated with cyclin A. This complex…”
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Synthesis of HDAC Substrate Peptidomimetic Inhibitors Using Fmoc Amino Acids Incorporating Zinc-Binding Groups by Mahindra, Amit, Millard, Christopher J, Black, Iona, Archibald, Lewis J, Schwabe, John W. R, Jamieson, Andrew G

“…Syntheses of Fmoc amino acids having zinc-binding groups were prepared and incorporated into substrate inhibitor H3K27 peptides using Fmoc/tBu solid-phase…”
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The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor by Zhang, Li, Fairall, Louise, Goult, Benjamin T, Calkin, Anna C, Hong, Cynthia, Millard, Christopher J, Tontonoz, Peter, Schwabe, John W R

“…We previously identified the E3 ubiquitin ligase IDOL as a sterol-dependent regulator of the LDL receptor (LDLR). The molecular pathway underlying IDOL action,…”
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A de novo substitution in BCL11B leads to loss of interaction with transcriptional complexes and craniosynostosis by Goos, Jacqueline A C, Vogel, Walter K, Mlcochova, Hana, Millard, Christopher J, Esfandiari, Elahe, Selman, Wisam H, Calpena, Eduardo, Koelling, Nils, Carpenter, Evan L, Swagemakers, Sigrid M A, van der Spek, Peter J, Filtz, Theresa M, Schwabe, John W R, Iwaniec, Urszula T, Mathijssen, Irene M J, Leid, Mark, Twigg, Stephen R F

“…Craniosynostosis, the premature ossification of cranial sutures, is a developmental disorder of the skull vault, occurring in approximately 1 in 2250 births…”
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Hydroxamic Acid-Modified Peptide Library Provides Insights into the Molecular Basis for the Substrate Selectivity of HDAC Corepressor Complexes by Archibald, Lewis J., Brown, Edward A., Millard, Christopher J., Watson, Peter J., Robertson, Naomi S., Wang, Siyu, Schwabe, John W. R., Jamieson, Andrew G.

“…Targeting the lysine deacetylase activity of class I histone deacetylases (HDACs) is potentially beneficial for the treatment of several diseases including…”
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Identification and structural analysis of type I collagen sites in complex with fibronectin fragments by Erat, Michèle C, Slatter, David A, Lowe, Edward D, Millard, Christopher J, Farndale, Richard W, Campbell, Iain D, Vakonakis, Ioannis

“…Collagen and fibronectin are major components of vertebrate extracellular matrices. Their association and distribution control the development and properties…”
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Recombinant protein expression for structural biology in HEK 293F suspension cells: a novel and accessible approach by Portolano, Nicola, Watson, Peter J, Fairall, Louise, Millard, Christopher J, Milano, Charles P, Song, Yun, Cowley, Shaun M, Schwabe, John W R

“…The expression and purification of large amounts of recombinant protein complexes is an essential requirement for structural biology studies. For over two…”
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