Search Results - "Millard, C."

Searching for the causal effects of body mass index in over 300 000 participants in UK Biobank, using Mendelian randomization by Millard, Louise A C, Davies, Neil M, Tilling, Kate, Gaunt, Tom R, Davey Smith, George

“…Mendelian randomization (MR) has been used to estimate the causal effect of body mass index (BMI) on particular traits thought to be affected by BMI. However,…”
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Association of physical activity intensity and bout length with mortality: An observational study of 79,503 UK Biobank participants by Millard, Louise A C, Tilling, Kate, Gaunt, Tom R, Carslake, David, Lawlor, Deborah A

“…Spending more time active (and less sedentary) is associated with health benefits such as improved cardiovascular health and lower risk of all-cause mortality…”
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Enhanced Striatal Dopamine Release During Food Stimulation in Binge Eating Disorder by Wang, Gene‐Jack, Geliebter, Allan, Volkow, Nora D., Telang, Frank W., Logan, Jean, Jayne, Millard C., Galanti, Kochavi, Selig, Peter A., Han, Hao, Zhu, Wei, Wong, Christopher T., Fowler, Joanna S.

“…Subjects with binge eating disorder (BED) regularly consume large amounts of food in short time periods. The neurobiology of BED is poorly understood. Brain…”
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Identifying the potential causal role of insomnia symptoms on 11,409 health-related outcomes: a phenome-wide Mendelian randomisation analysis in UK Biobank by Gibson, Mark J, Lawlor, Deborah A, Millard, Louise A C

“…Insomnia symptoms are widespread in the population and might have effects on many chronic conditions and their risk factors but previous research has focused…”
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MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging by Millard, Louise A C, Munafò, Marcus R, Tilling, Kate, Wootton, Robyn E, Davey Smith, George

“…Mendelian randomization (MR) is an established approach to evaluate the effect of an exposure on an outcome. The gene-by-environment (GxE) study design can be…”
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A cross-disorder PRS-pheWAS of 5 major psychiatric disorders in UK Biobank by Leppert, Beate, Millard, Louise A C, Riglin, Lucy, Davey Smith, George, Thapar, Anita, Tilling, Kate, Walton, Esther, Stergiakouli, Evie

“…Psychiatric disorders are highly heritable and associated with a wide variety of social adversity and physical health problems. Using genetic liability (rather…”
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The Adaptive Trade-Off between Detection and Discrimination in Cortical Representations and Behavior by Ollerenshaw, Douglas R., Zheng, He J.V., Millard, Daniel C., Wang, Qi, Stanley, Garrett B.

“…It has long been posited that detectability of sensory inputs can be sacrificed in favor of improved discriminability and that sensory adaptation may mediate…”
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Characterization of the Myosin-Based Source for Second-Harmonic Generation from Muscle Sarcomeres by Plotnikov, Sergey V., Millard, Andrew C., Campagnola, Paul J., Mohler, William A.

“…Several biologically important protein structures give rise to strong second-harmonic generation (SHG) in their native context. In addition to high-contrast…”
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The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization by Korologou-Linden, Roxanna, Bhatta, Laxmi, Brumpton, Ben M., Howe, Laura D., Millard, Louise A. C., Kolaric, Katarina, Ben-Shlomo, Yoav, Williams, Dylan M., Smith, George Davey, Anderson, Emma L., Stergiakouli, Evie, Davies, Neil M.

“…Alzheimer’s disease (AD) has no proven causal and modifiable risk factors, or effective interventions. We report a phenome-wide association study (PheWAS) of…”
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Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study by Magnus, Maria C, Guyatt, Anna L, Lawn, Rebecca B, Wyss, Annah B, Trajanoska, Katerina, Küpers, Leanne K, Rivadeneira, Fernando, Tobin, Martin D, London, Stephanie J, Lawlor, Debbie A, Millard, Louise A C, Fraser, Abigail

“…Age at menarche has been associated with various health outcomes. We aimed to identify potential causal effects of age at menarche on health-related traits in…”
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Correction: Association of physical activity intensity and bout length with mortality: An observational study of 79,503 UK Biobank participants by Millard, Louise A C, Tilling, Kate, Gaunt, Tom R, Carslake, David, Lawlor, Deborah A

“…[This corrects the article DOI: 10.1371/journal.pmed.1003757.]…”
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Optogenetic feedback control of neural activity by Newman, Jonathan P, Fong, Ming-fai, Millard, Daniel C, Whitmire, Clarissa J, Stanley, Garrett B, Potter, Steve M

“…Optogenetic techniques enable precise excitation and inhibition of firing in specified neuronal populations and artifact-free recording of firing activity…”
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Accounting for bias due to outcome data missing not at random: comparison and illustration of two approaches to probabilistic bias analysis: a simulation study by Kawabata, Emily, Major-Smith, Daniel, Clayton, Gemma L., Shapland, Chin Yang, Morris, Tim P., Carter, Alice R., Fernández-Sanlés, Alba, Borges, Maria Carolina, Tilling, Kate, Griffith, Gareth J., Millard, Louise A. C., Smith, George Davey, Lawlor, Deborah A., Hughes, Rachael A.

“…Abstract Background Bias from data missing not at random (MNAR) is a persistent concern in health-related research. A bias analysis quantitatively assesses how…”
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Behavioral and electrophysiological effects of cortical microstimulation parameters by Bari, Bilal A, Ollerenshaw, Douglas R, Millard, Daniel C, Wang, Qi, Stanley, Garrett B

“…Electrical microstimulation has been widely used to artificially activate neural circuits on fast time scales. Despite the ubiquity of its use, little is known…”
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Three-Dimensional High-Resolution Second-Harmonic Generation Imaging of Endogenous Structural Proteins in Biological Tissues by Campagnola, Paul J., Millard, Andrew C., Terasaki, Mark, Hoppe, Pamela E., Malone, Christian J., Mohler, William A.

“…We find that several key endogenous protein structures give rise to intense second-harmonic generation (SHG)—nonabsorptive frequency doubling of an excitation…”
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Removal of Acidic Impurities from Corn Stover Hydrolysate Liquor by Resin Wafer Based Electrodeionization by Datta, Saurav, Lin, Yupo J, Schell, Daniel J, Millard, C. S, Ahmad, Sabeen F, Henry, Michael P, Gillenwater, P, Fracaro, Anthony T, Moradia, A, Gwarnicki, Zofia P, Snyder, Seth W

“…Dilute acid (sulfuric acid) pretreatment of lignocellulosic biomass releases monomeric xylose, xylo-oligomers, and acetic acid by degradation of hemicellulose…”
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Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine by Bar-On, P, Millard, C. B, Harel, M, Dvir, H, Enz, A, Sussman, J. L, Silman, I

“…Rivastigmine, a carbamate inhibitor of acetylcholinesterase, is already in use for treatment of Alzheimer's disease under the trade name of Exelon…”
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Characterization and Application of a New Optical Probe for Membrane Lipid Domains by Jin, Lei, Millard, Andrew C., Wuskell, Joseph P., Dong, Xuemei, Wu, Dianqing, Clark, Heather A., Loew, Leslie M.

“…In this article, we characterize the fluorescence of an environmentally sensitive probe for lipid membranes, di-4-ANEPPDHQ. In large unilamellar lipid vesicles…”
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Challenges in using data on fathers/partners to study prenatal exposures and offspring health by Easey, Kayleigh E, Gkatzionis, Apostolos, Millard, Louise A C, Tilling, Kate, Lawlor, Deborah A, Sharp, Gemma C

“…Paternal exposures (and other non-maternal factors) around pregnancy could have important effects on offspring health. One challenge is that data on partners…”
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Second harmonic generation imaging of endogenous structural proteins by Mohler, William, Millard, Andrew C., Campagnola, Paul J.

“…We show that structural protein arrays consisting largely of collagen, myosin, and tubulin, and their associated proteins can be imaged in three dimensions…”
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