Search Results - "Millar, R. P"

Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men by George, J. T, Veldhuis, J. D, Roseweir, A. K, Newton, C. L, Faccenda, E, Millar, R. P, Anderson, R. A

“…Context: Kisspeptins stimulate GnRH and thus gonadotropin secretion. Kisspeptin-10 is the minimal kisspeptin sequence with full intrinsic bioactivity, but it…”
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Critical Roles of Kisspeptins in Female Puberty and Preovulatory Gonadotropin Surges as Revealed by a Novel Antagonist by Pineda, R, Garcia-Galiano, D, Roseweir, A, Romero, M, Sanchez-Garrido, M. A, Ruiz-Pino, F, Morgan, K, Pinilla, L, Millar, R. P, Tena-Sempere, M

“…Kisspeptins (Kp) have recently emerged as master regulators of the reproductive axis and among the most potent elicitors of GnRH-gonadotropin secretion…”
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KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction by Gaytán, F, Gaytán, M, Castellano, J M, Romero, M, Roa, J, Aparicio, B, Garrido, N, Sánchez-Criado, J E, Millar, R P, Pellicer, A, Fraser, H M, Tena-Sempere, M

“…Kisspeptins, the products of the KiSS-1 gene acting via G protein-coupled receptor 54 (GPR54), have recently emerged as pivotal signals in the hypothalamic…”
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Suppression of the GnRH Pulse Generator by Neurokinin B Involves a κ-Opioid Receptor-Dependent Mechanism by Grachev, P, Li, X. F, Kinsey-Jones, J. S, di Domenico, A. L, Millar, R. P, Lightman, S. L, O'Byrne, K. T

“…Neurokinin B (NKB) and its receptor (NK3R) are coexpressed with kisspeptin, Dynorphin A (Dyn), and their receptors [G-protein-coupled receptor-54 (GPR54)] and…”
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In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation by Albers-Wolthers, C H J, de Gier, J, Walen, M, van Kooten, P J S, Lambalk, C B, Leegwater, P A J, Roelen, B A J, Schaefers-Okkens, A C, Rutten, V P M G, Millar, R P M, Kooistra, H S

“…Kisspeptins (KPs) and their receptor (GPR54 or KiSS1R) play a key-role in regulation of the hypothalamic-pituitary-gonadal axis and are therefore interesting…”
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Kisspeptin Is Present in Ovine Hypophysial Portal Blood But Does Not Increase during the Preovulatory Luteinizing Hormone Surge: Evidence that Gonadotropes Are Not Direct Targets of Kisspeptin in Vivo by Smith, J. T, Rao, A, Pereira, A, Caraty, A, Millar, R. P, Clarke, I. J

“…There is strong evidence that kisspeptin acts to regulate GnRH secretion, but whether there is also a component of action on the gonadotropes is not clear…”
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Kisspeptin-10 stimulation of gonadotrophin secretion in women is modulated by sex steroid feedback by George, J.T., Anderson, R.A., Millar, R.P.

“…STUDY QUESTION Does sex-steroid feedback influence gonadotrophin responses to kisspeptin-10? SUMMARY ANSWER Gonadotrophin response to kisspeptin-10 is enhanced…”
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Prevalence and Molecular Characterization of Dirofilaria immitis (Filarioidea: Onchocercidae) in Dogs from Endemic Areas of Rio De Janeiro State, Brazil by Silva, M. S. G, Leles, D, Sudré, A. P, Millar, P. R, Uchôa, F, Brener, B

“…Canine dirofilariasis is common in Brazil, but molecular diagnosis is rare even though molecular studies increase our knowledge about molecular epidemiology…”
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Kisspeptin-10 inhibits cell migration in vitro via a receptor-GSK3 beta-FAK feedback loop in HTR8SVneo cells by Roseweir, A.K, Katz, A.A, Millar, R.P

“…Abstract Kisspeptin inhibits cancer cell metastasis and placental trophoblast cell migration. Kisspeptin gene expression in the placenta and circulating…”
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Effect of gonadotropin‐inhibitory hormone on luteinizing hormone secretion in humans by George, J.T., Hendrikse, M., Veldhuis, J.D., Clarke, I.J., Anderson, R.A., Millar, R.P.

“…Summary Background Gonadotropin‐inhibitory hormone (GnIH, human homologue of RFRP‐3) suppresses gonadotropin secretion in animal models, but its effects have…”
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Expression and Regulation of the Prokineticins (Endocrine Gland-Derived Vascular Endothelial Growth Factor and Bv8) and Their Receptors in the Human Endometrium across the Menstrual Cycle by Battersby, S., Critchley, H. O. D., Morgan, K., Millar, R. P., Jabbour, H. N.

“…This study investigated the possible role of the newly discovered endocrine gland-derived vascular endothelial growth factors and their cognate receptors in…”
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Policy Decisions on Endocrine Disruptors Should Be Based on Science Across Disciplines: A Response to Dietrich et al by Gore, A. C, Balthazart, J, Bikle, D, Carpenter, D. O, Crews, D, Czernichow, P, Diamanti-Kandarakis, E, Dores, R. M, Grattan, D, Hof, P. R, Hollenberg, A. N, Lange, C, Lee, A. V, Levine, J. E, Millar, R. P, Nelson, R. J, Porta, M, Poth, M, Power, D. M, Prins, G. S, Ridgway, E. C, Rissman, E. F, Romijn, J. A, Sawchenko, P. E, Sly, P. D, Söder, O, Taylor, H. S, Tena-Sempere, M, Vaudry, H, Wallen, K, Wang, Z, Wartofsky, L, Watson, C. S

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Evidence that the Type-2 Gonadotrophin-Releasing Hormone (GnRH) Receptor Mediates the Behavioural Effects of GnRH-II on Feeding and Reproduction in Musk Shrews by Kauffman, A. S., Wills, A., Millar, R. P., Rissman, E. F.

“…Gonadotrophin‐releasing hormone (GnRH) is a regulatory neuropeptide of which there are multiple structural variants. In mammals, a hypothalamic form (GnRH‐I)…”
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The curious case of the hypothalamic–pituitary–gonadal axis dysfunction in subordinate female naked mole‐rats (Heterocephalus glaber): No apparent role of opioids and glucocorticoids by Hart, Daniel W., Roberts, E., O'Riain, M. J., Millar, R. P., Bennett, N. C.

“…The naked mole‐rat (Heterocephalus glaber) is a unique model mammal in which to study socially induced inhibition of the hypothalamic–pituitary–gonadal (HPG)…”
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Contrast Imaging Ultrasound Detects Abnormalities in the Marmoset Ovary by HASTINGS, J. M., MORRIS, K. D., ALLAN, D., WILSON, H., MILLAR, R. P., FRASER, H. M., MORAN, C. M.

“…The development of a functional vascular tree within the primate ovary is critical for reproductive health. To determine the efficacy of contrast agents to…”
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The role of kisspeptin in the control of gonadotrophin secretion by Roseweir, A.K., Millar, R.P.

“…BACKGROUND Kisspeptins, and their cognate receptor gpr-54, were first found to regulate the hypothalamic–pituitary–gonadal (HPG) axis in 2003, when two groups…”
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Hypothalamic Pro-GnRH-GAP, GnRH-I and GnRH-II During the Onset of Photorefractoriness in the White-Crowned Sparrow (Zonotrichia leucophrys gambelii) by Meddle, S. L., Bush, S., Sharp, P. J., Millar, R. P., Wingfield, J. C.

“…Gambel's white‐crowned sparrow is a long distance migrant that undergoes spontaneous gonadal regression as a result of long day exposure. This termination of…”
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Spatio-Temporal Expression of Gonadotropin-Releasing Hormone Receptor Subtypes in Gonadotropes, Somatotropes and Lactotropes in the Cichlid Fish by Parhar, I. S., Soga, T., Sakuma, Y., Millar, R. P.

“…The description of two or more forms of gonadotropin‐releasing hormone (GnRH) in most vertebrates suggests multiple roles for this family of peptide hormones…”
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The role of neurokinin B signalling in reproductive neuroendocrinology by Grachev, P, Millar, R P, O'Byrne, K T

“…The KNDy neuropeptides, kisspeptin, neurokinin B (NKB) and dynorphin A (Dyn), have been implicated in regulating pulsatile luteinising hormone (LH) secretion…”
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Policy decisions on endocrine disruptors should be based on science across disciplines: a response to Dietrich et al by Gore, A C, Balthazart, J, Bikle, D, Carpenter, D O, Crews, D, Czernichow, P, Diamanti-Kandarakis, E, Dores, R M, Grattan, D, Hof, P R, Hollenberg, A N, Lange, C, Lee, A V, Levine, J E, Millar, R P, Nelson, R J, Porta, M, Poth, M, Power, D M, Prins, G S, Ridgway, E C, Rissman, E F, Romijn, J A, Sawchenko, P E, Sly, P D, Söder, O, Taylor, H S, Tena-Sempere, M, Vaudry, H, Wallen, K, Wang, Z, Wartofsky, L, Watson, C S

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