Search Results - "Millan, JL"

Glycoproteomic profile of human tissue-nonspecific alkaline phosphatase expressed in osteoblasts by Atanasova, Diana, Mirgorodskaya, Ekaterina, Moparthi, Lavanya, Koch, Stefan, Haarhaus, Mathias, Narisawa, Sonoko, Millán, José Luis, Landberg, Eva, Magnusson, Per

“…Tissue-nonspecific alkaline phosphatase (TNALP) is a glycoprotein expressed by osteoblasts that promotes bone mineralization. TNALP catalyzes the hydrolysis of…”
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Bone Alkaline Phosphatase and Tartrate-Resistant Acid Phosphatase: Potential Co-regulators of Bone Mineralization by Halling Linder, Cecilia, Ek-Rylander, Barbro, Krumpel, Michael, Norgård, Maria, Narisawa, Sonoko, Millán, José Luis, Andersson, Göran, Magnusson, Per

“…Phosphorylated osteopontin (OPN) inhibits hydroxyapatite crystal formation and growth, and bone alkaline phosphatase (BALP) promotes extracellular…”
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Lack of mutations in the RANK gene in Spanish patients with Paget disease of bone by Marco-Mingot, M, San-Millán, JL, Wuyts, W, Bachiller-Corral, J, Van Hul, W, Morales-Piga, AA

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Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: Potential mechanism for uremic vascular calcification by Lomashvili, K.A., Garg, P., Narisawa, S., Millan, J.L., O'Neill, W.C.

“…Pyrophosphate is a potent inhibitor of medial vascular calcification where its level is controlled by hydrolysis via a tissue-nonspecific alkaline phosphatase…”
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Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone by Murshed, Monzur, Harmey, Dympna, Millán, José Luis, McKee, Marc D, Karsenty, Gerard

“…Extracellular matrix (ECM) mineralization is a physiological process in bone and a pathological one in soft tissues. The mechanisms determining the spatial…”
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Concerted Regulation of Inorganic Pyrophosphate and Osteopontin by Akp2, Enpp1, and Ank: An Integrated Model of the Pathogenesis of Mineralization Disorders by Harmey, Dympna, Hessle, Lovisa, Narisawa, Sonoko, Johnson, Kristen A, Terkeltaub, Robert, Millan, Jose Luis

“…Tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes the mineralization inhibitor inorganic pyrophosphate (PP(i)). Deletion of the TNAP gene (Akp2) in…”
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Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase by Bessueille, L., Briolay, A., Como, J., Mebarek, S., Mansouri, C., Gleizes, M., El Jamal, A., Buchet, R., Dumontet, C., Matera, E.L., Mornet, E., Millan, J.L., Fonta, C., Magne, D.

“…Tissue-nonspecific alkaline phosphatase (TNAP) is necessary for skeletal mineralization by its ability to hydrolyze the mineralization inhibitor inorganic…”
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The Polycystic Ovary Syndrome Associated with Morbid Obesity May Resolve after Weight Loss Induced by Bariatric Surgery by Escobar-Morreale, Héctor F., Botella-Carretero, José I., Álvarez-Blasco, Francisco, Sancho, José, San Millán, José L.

“…Context: The polycystic ovary syndrome (PCOS) is frequently associated with obesity. However, there are very few data about PCOS in morbid obesity, especially…”
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The Molecular-Genetic Basis of Functional Hyperandrogenism and the Polycystic Ovary Syndrome by Escobar-Morreale, Héctor F, Luque-Ramírez, Manuel, San Millán, José L

“…The genetic mechanisms underlying functional hyperandrogenism and the polycystic ovary syndrome (PCOS) remain largely unknown. Given the large number of…”
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A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain by ASUNCION, M, CALVO, R. M, SAN MILLAN, J. L, SANCHO, J, AVILA, S, ESCOBAR-MORREALE, H. F

“…We prospectively estimated the prevalence of the polycystic ovary syndrome (PCOS), as defined by the NIH/NICHHD 1990 endocrine criteria, in a population of 154…”
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Tissue-Nonspecific Alkaline Phosphatase and Plasma Cell Membrane Glycoprotein-1 are Central Antagonistic Regulators of Bone Mineralization by Hessle, Lovisa, Johnson, Kristen A., Anderson, H. Clarke, Narisawa, Sonoko, Sali, Adnan, Goding, James W., Terkeltaub, Robert, Millán, José Luis

“…Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formation and growth in the interior of membrane-limited matrix vesicles (MVs) and by…”
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Impaired Calcification Around Matrix Vesicles of Growth Plate and Bone in Alkaline Phosphatase-Deficient Mice by Anderson, H. Clarke, Sipe, Joseph B., Hessle, Lovisa, Dhamyamraju, Rama, Atti, Elisa, Camacho, Nancy P., Millán, José Luis

“…The presence of skeletal hypomineralization was confirmed in mice lacking the gene for bone alkaline phosphatase, ie, the tissue-non-specific isozyme of…”
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Receiver operating characteristic analysis of the performance of basal serum hormone profiles for the diagnosis of polycystic ovary syndrome in epidemiological studies by ESCOBAR-MORREALE, Héctor F, ASUNCION, Miryam, CALVO, Rosa M, SANCHO, José, SAN MILLAN, José L

“…We have used receiver operating characteristic (ROC) analysis to determine the diagnostic performance of several serum parameters, in order to evaluate their…”
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Tooth root dentin mineralization defects in a mouse model of hypophosphatasia by Foster, BL, Nagatomo, KJ, Tso, HW, Tran, AB, Nociti, FH, Narisawa, S, Yadav, MC, McKee, MD, Millán, JL, Somerman, MJ

“…Tissue‐nonspecific alkaline phosphatase (TNAP) is expressed in mineralizing tissues and functions to reduce pyrophosphate (PPi), a potent inhibitor of…”
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Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study by Escobar-Morreale, H.F., Villuendas, G., Botella-Carretero, J.I., Álvarez-Blasco, F., Sanchón, R., Luque-Ramírez, M., San Millán, J.L.

“…We conducted a cross-sectional case–control study to evaluate the possible involvement of adiponectin and resistin in the pathogenesis of polycystic ovary…”
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Accelerated Fat Absorption in Intestinal Alkaline Phosphatase Knockout Mice by Narisawa, Sonoko, Huang, Lei, Iwasaki, Arata, Hasegawa, Hideaki, Alpers, David H., Millán, José Luis

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Association of the Polycystic Ovary Syndrome with Genomic Variants Related to Insulin Resistance, Type 2 Diabetes Mellitus, and Obesity by San Millán, José L., Cortón, Marta, Villuendas, Gemma, Sancho, José, Peral, Belén, Escobar-Morreale, Héctor F.

“…We have evaluated the possible association of polycystic ovary syndrome (PCOS) with 15 genomic variants previously described to influence insulin resistance,…”
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Linked Deficiencies in Extracellular PPi and Osteopontin Mediate Pathologic Calcification Associated With Defective PC‐1 and ANK Expression by Johnson, Kristen, Goding, James, Van Etten, Deborah, Sali, Adnan, Hu, Shou‐Ih, Farley, David, Krug, Hollis, Hessle, Lovisa, Millán, José Luis, Terkeltaub, Robert

“…Osteopontin and PPi both suppress hydroxyapatite deposition. Extracellular PPi deficiency causes spontaneous hypercalcification, yet unchallenged osteopontin…”
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Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(-/-) and Phospho1/Pi t1 Double-Knockout Mice by Yadav, Manisha C, Bottini, Massimo, Cory, Esther, Bhattacharya, Kunal, Kuss, Pia, Narisawa, Sonoko, Sah, Robert L, Beck, Laurent, Fadeel, Bengt, Farquharson, Colin, Millán, José Luis

“…We have previously shown that ablation of either the Phospho1 or Alpl gene, encoding PHOSPHO1 and tissue-nonspecific alkaline phosphatase (TNAP) respectively,…”
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Serum Interleukin-18 Concentrations Are Increased in the Polycystic Ovary Syndrome: Relationship to Insulin Resistance and to Obesity by Escobar-Morreale, Héctor F., Botella-Carretero, José I., Villuendas, Gemma, Sancho, José, San Millán, José L.

“…Low-grade chronic inflammation is involved in the pathogenesis of the metabolic syndrome and atherosclerosis, and serum levels of inflammatory cytokines are…”
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