Search Results - "Miljanovic, Nina"
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Proteomic signature of the Dravet syndrome in the genetic Scn1a-A1783V mouse model
Published in Neurobiology of disease (01-09-2021)“…Dravet syndrome is a rare, severe pediatric epileptic encephalopathy associated with intellectual and motor disabilities. Proteomic profiling in a mouse model…”
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Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus
Published in Neurobiology of disease (01-09-2020)“…In addition to tissues such as liver, the plasma membrane sodium-dependent citrate transporter, NaCT (SLC13A5), is highly expressed in brain neurons, but its…”
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Anesthesia and analgesia for experimental craniotomy in mice and rats: a systematic scoping review comparing the years 2009 and 2019
Published in Frontiers in neuroscience (03-05-2023)“…Experimental craniotomies are a common surgical procedure in neuroscience. Because inadequate analgesia appears to be a problem in animal-based research, we…”
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The impact of Scn1a deficiency and ketogenic diet on the intestinal microbiome: A study in a genetic Dravet mouse model
Published in Epilepsy research (01-12-2021)“…The gut-brain axis has been discussed as a possible factor contributing to ictogenesis and epilepsy. While recent preclinical studies have proposed a link…”
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Metabolomic signature of the Dravet syndrome: A genetic mouse model study
Published in Epilepsia (Copenhagen) (01-08-2021)“…Objective Alterations in metabolic homeostasis can contribute to neuronal hyperexcitability and seizure susceptibility. Although the pivotal role of impaired…”
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Behavioral phenotyping of young Scn1a haploinsufficient mice
Published in Epilepsy & behavior (01-11-2022)“…•Scn1a-A1783V haploinsufficient mice display age-dependent phenotypic alterations.•The course of behavioral patterns confirmed the overall face validity of the…”
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Integrity of the circadian clock determines regularity of high-frequency and diurnal LFP rhythms within and between brain areas
Published in Molecular psychiatry (29-10-2024)“…Circadian clocks control most physiological processes of many species. We specifically wanted to investigate the influence of environmental and endogenous…”
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Evaluation of variation in preclinical electroencephalographic
Published in PloS one (29-10-2024)“…The European Quality In Preclinical Data (EQIPD) consortium was born from the fact that publications report challenges with the robustness, rigor, and/or…”
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Defining body-weight reduction as a humane endpoint: a critical appraisal
Published in Laboratory animals (London) (01-02-2020)“…In many animal experiments scientists and local authorities define a body-weight reduction of 20% or more as severe suffering and thereby as a potential…”
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Toward evidence-based severity assessment in mouse models with repeated seizures: I. Electrical kindling
Published in Epilepsy & behavior (01-02-2021)“…•For amygdala- and hippocampal-kindled mice, alterations are widely comparable.•Open-field paradigm and the saccharin preference test are of interest for…”
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Evaluation of variation in preclinical electroencephalographic (EEG) spectral power across multiple laboratories and experiments: An EQIPD study
Published in PloS one (29-10-2024)“…The European Quality In Preclinical Data (EQIPD) consortium was born from the fact that publications report challenges with the robustness, rigor, and/or…”
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Semi-automated generation of pictures for the Mouse Grimace Scale: A multi-laboratory analysis (Part 2)
Published in Laboratory animals (London) (01-02-2020)“…The Mouse Grimace Scale (MGS) is an established method for estimating pain in mice during animal studies. Recently, an improved and standardized MGS set-up and…”
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