Search Results - "Militão, Gardênia Carmen"

Multicomponent synthesis of spiro 1,3,4‐thiadiazolines with anticancer activity by using deep eutectic solvent under microwave irradiation by Castro, Aleff, Andrade, Isadora Maria Gouveia, Coelho, Maísa Cavalcanti, Costa, Daniel Pereira, Moreira, Dayse das Neves, Maia, Rachel Azevedo, Lima, Gesiane da Silva, Santos, Gabriel Franco, Vaz, Boniek Gontijo, Militão, Gardênia Carmen Gadelha, Silva, Paulo Bruno Norberto, Vasconcellos, Mário Luiz Araujo de Almeida, Lima‐Junior, Claudio Gabriel

“…This work describes a simple and efficient alternative method for obtaining 1,3,4‐thiadialzolinic spirocompounds, combining the use of deep eutectic solvents…”
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Synthesis of 2-amino-4H-chromenes catalyst-free via sequential Knoevenagel-Michael reaction and evaluation of biological activity in tumor cells by de Abrantes, Poliana Gomes, de Abrantes, Paloma Gomes, dos Santos Silva, Damião Alves, Magalhães, Renata Rodrigues, da Silva, Paulo Bruno Norberto, Militão, Gardenia Carmen Gadelha, de Menezes, Renata Priscila Barros, Scotti, Luciana, Scotti, Marcus Tullius, Vale, Juliana Alves

“…This work focuses on investigating solvents for the catalyst-free synthesis of 2-amino-4H-chromenes from salicylaldehydes and malononitrile through the…”
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Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features by Ferreira, Paulo Michel Pinheiro, Ferreira, José Roberto de Oliveira, Sousa, Rayran Walter Ramos de, Bezerra, Daniel Pereira, Militão, Gardenia Carmen Gadelha

“…The indiscriminate consumption of antimalarials against coronavirus disease-2019 emphasizes the longstanding clinical weapons of medicines. In this work, we…”
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In vitro antioxidant and cytotoxic activity of some synthetic riparin-derived compounds by Nunes, Geandra B L, Policarpo, Paola R, Costa, Luciana M, da Silva, Teresinha G, Militão, Gardenia Carmen G, Câmara, Celso A, Barbosa Filho, José Maria, Gutierrez, Stanley Juan C, Islam, Mohammed T, de Freitas, Rivelilson M

“…This study aimed to study the in vitro antioxidant activity and cytotoxicity on tumor cells lines of six synthetic substances derived from riparins. All the…”
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The Dual Antioxidant/Prooxidant Effect of Eugenol and Its Action in Cancer Development and Treatment by Bezerra, Daniel Pereira, Militão, Gardenia Carmen Gadelha, de Morais, Mayara Castro, de Sousa, Damião Pergentino

“…The formation of reactive oxygen species (ROS) during metabolism is a normal process usually compensated for by the antioxidant defense system of an organism…”
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Toxicological, chemopreventive, and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS) by Silva, Jurandy do Nascimento, Monção, Nayana Bruna Nery, de Farias, Ruth Raquel Soares, Citó, Antonia Maria das Graças Lopes, Chaves, Mariana Helena, Araújo, Mônica Regina Silva de, Lima, Daisy Jereissati Barbosa, Pessoa, Claudia, Lima, Alessandro de, Araújo, Edigênia Cavalcante da Cruz, Militão, Gardenia Carmen Gadelha, Costa, Marcília Pinheiro da, Capasso, Raffaele, Ferreira, Paulo Michel Pinheiro

“…Caatinga flora which are found in a poor Brazilian region contain a substantial number of endemic taxa with biomedical and social importance for regional…”
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Effects of lipoic acid on oxidative stress in rat striatum after pilocarpine-induced seizures by Militão, Gardenia Carmen Gadelha, Ferreira, Paulo Michel Pinheiro, de Freitas, Rivelilson Mendes

“…The relationship between free radical and scavenger enzymes has been found in the epilepsy and reactive oxygen species have been implicated in seizure-induced…”
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Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways by Bezerra, Daniel Pereira, Militão, Gardenia Carmen Gadelha, de Castro, Fernanda Oliveira, Pessoa, Cláudia, de Moraes, Manoel Odorico, Silveira, Edilberto Rocha, Lima, Mary Anne Sousa, Elmiro, Francisca Juliana Martins, Costa-Lotufo, Letícia Veras

“…Piplartine {5,6-dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)pyridinone} is an alkaloid/amide component of Piper species. The purpose of the…”
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Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms by Ferreira, Paulo Michel Pinheiro, Sousa, Rayran Walter Ramos de, Ferreira, José Roberto de Oliveira, Militão, Gardenia Carmen Gadelha, Bezerra, Daniel Pereira

“…Chloroquine (CQ) and hydroxychloroquine (HCQ) are the most common drugs used to relieve acute and chronic inflammatory diseases. In this article, we present a…”
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Natural Dibenzo[b,f]oxepines, Pacharin and Bauhiniastatin-1, Isolated from Bauhinia acuruana Induce Apoptosis on Breast Cancer Cells via MCL-1 Protein Reduction by Souza, Silvia de Maria, Souza, Luciano Santos de, Silva, Valdenizia Rodrigues, Soares, Milena Botelho Pereira, Bezerra, Daniel Pereira, Gois, Roberto Wagner da Silva, Silva, Horlando Carlota da, Santiago, Gilvandete Maria Pinheiro, Militao, Gardenia Carmen Gadelha

“…Herein, we describe the antiproliferative effects of two natural dibenzo [ ]oxepines, pacharin and bauhiniastatin-1, isolated from on a breast cancer cell line…”
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Cytotoxic Flavonoids from Platymiscium floribundum by Falcão, Maria José C, Pouliquem, Yvone Brígido M, Lima, Mary Anne S, Gramosa, Nilce Viana, Costa-Lotufo, Letícia V, Militão, Gardênia Carmen G, Pessoa, Cláudia, Odorico de Moraes, Manoel, Silveira, Edilberto R

“…Two new isoflavonoids, 7-hydroxy-6,4‘-dimethoxy-isoflavonequinone (1) and 2‘-hydroxy-6,4‘,6‘ ‘,4‘ ‘‘-tetramethoxy-[7-O-7‘ ‘]-bisisoflavone (2), and seven other…”
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Selective cytotoxicity of withaphysalins in myeloid leukemia cell lines versus peripheral blood mononuclear cells by Damasceno Rocha, Danilo, Gadelha Militão, Gardenia Carmen, Veras, Maria Leopoldina, Deusdênia Loiola Pessoa, Otília, Rocha Silveira, Edilberto, Negreiros Nunes Alves, Ana Paula, Odorico de Moraes, Manoel, Pessoa, Cláudia, Veras Costa-Lotufo, Letícia

“…Withaphysalins are C 28-steroidal lactones structurally based on the ergostane skeleton that possess antiproliferative activity against tumor cell lines. In…”
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Anticancer activity of β-Lapachone derivatives on human leukemic cell lines by de Andrade, Jeyce Kelle Ferreira, da Silva Góes, Alexandre José, Barbosa, Vanessa Xavier, de Lima Silva, Mariza Severina, Matos Donato, Mariana Aragão, Peixoto, Christina Alves, Militão, Gardênia Carmen Gadelha, da Silva, Teresinha Gonçalves

“…β-lapachone is a 1,2-naphthoquinone of great therapeutic interest that induces cell death by autophagy and apoptosis in tumor cells due to oxidative stress…”
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Anti-liver cancer activity in vitro and in vivo induced by 2-pyridyl 2,3-thiazole derivatives by dos Santos Silva, Thiago David, Bomfim, Larissa Mendes, da Cruz Rodrigues, Ana Carolina Borges, Dias, Rosane Borges, Sales, Caroline Brandi Schlaepfer, Rocha, Clarissa Araújo Gurgel, Soares, Milena Botelho Pereira, Bezerra, Daniel Pereira, de Oliveira Cardoso, Marcos Veríssimo, Leite, Ana Cristina Lima, Militão, Gardenia Carmen Gadelha

“…A total of 24 hybrid compounds containing pyridyl and 1,3-thiazole moieties were screened against HL-60 (leukemia), MCF-7 (breast adenocarcinoma), HepG2…”
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Marinobufagin, a molecule from poisonous frogs, causes biochemical, morphological and cell cycle changes in human neoplasms and vegetal cells by Machado, Kátia da Conceição, Sousa, Lívia Queiroz de, Lima, Daisy Jereissati Barbosa, Soares, Bruno Marques, Cavalcanti, Bruno Coêlho, Maranhão, Sarah Sant'Anna, Noronha, Janaina da Costa de, Rodrigues, Domingos de Jesus, Militão, Gardenia Carmen Gadelha, Chaves, Mariana Helena, Vieira-Júnior, Gerardo Magela, Pessoa, Cláudia, Moraes, Manoel Odorico de, Sousa, João Marcelo de Castro e, Melo-Cavalcante, Ana Amélia de Carvalho, Ferreira, Paulo Michel Pinheiro

“…[Display omitted] •Marinobufagin has high antiproliferative activity on human tumor lines only.•HL-60 cells displayed binucleation, cellular and nuclear…”
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Antileishmanial Activity of Warifteine : A Bisbenzylisoquinoline Alkaloid Isolated from Cissampelos sympodialis Eichl. (Menispermaceae) by Dias Rayol, Cynthia, da Silva, Eliete Cavalcanti, Medeiros, Paloma Lys de, Figueiredo, Regina Célia Bressan Queiroz, Piuvezan, Márcia Regina, Brabosa-Filho, José Maria, Fernandes Marinho, Alexsandro, da Silva, Teresinha Gonçalves, Militão, Gardenia Carmen Gadelha, Pimentel Cassilhas, Ana Paula, Paes de Andrade, Paulo

“…Leishmania (L.) chagasi is the etiological agent of visceral leishmaniasis, an important endemic zoonosis in the American continent, as well as in many other…”
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Antimitotic properties of pterocarpans isolated from Platymiscium floribundum on sea urchin eggs by Militão, Gardênia Carmen, Jimenez, Paula Christine, Wilke, Diego Veras, Pessoa, Cláudia, Falcão, Maria José, Sousa Lima, Mary Anne, Silveira, Edilberto Rocha, de Moraes, Manoel Odorico, Costa-Lotufo, Letícia Veras

“…This study reports the antimitotic effects on sea urchin eggs of five known pterocarpans: (+)-3,10-dihydroxy-9-methoxypterocarpan, (+)-3,9-dimethoxypterocarpan…”
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Morphological and biochemical alterations activated by antitumor clerodane diterpenes by Ferreira, Paulo Michel Pinheiro, Militão, Gardenia Carmen Gadelha, Lima, Daisy Jereissati Barbosa, Costa, Nagilla Daniela de Jesus, Machado, Kátia da Conceição, Santos, André Gonzaga dos, Cavalheiro, Alberto José, Bolzani, Vanderlan da Silva, Silva, Dulce Helena Siqueira, Pessoa, Cláudia

“…•Casearia sylvestris leaves have oxygenated tricyclic bioactive clerodane diterpenes.•Fraction and compounds from leaves were cytotoxic on human and mice tumor…”
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Non-clinical repeated dose 28-day oral toxicity, reproductive toxicity and cytotoxicity studies of the polar fraction of Parkinsonia aculeata aerial parts extract by Menezes, Tamires Meira, de Souza Franco, Eryvelton, de Almeida Sousa Lima, Larissa Caroline, de Souza Pereira, Áurea Marcela, de Santos Lima, Laísa Wanessa, Quixabeira, Carla Mirele Tabósa, da Silva, Janilson Felix, Cahu, Thiago Barbosa, de Souza Bezerra, Ranilson, Lira, Eduardo Carvalho, Militão, Gardênia Carmen Gadelha, de Sousa Maia, Maria Bernadete

“…Abstract This study was aimed to evaluate toxicity in repeated doses for 28 days, reproductive toxicity and cytotoxicity of a polar fraction obtained from the…”
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Antibacterial, cytotoxic, and schistosomicidal activities of the methanolic extract from Cassia grandis L.f. (Fabaceae) stem bark and its fractions by Luciméri, Paulino Machado Magalhães, Bárbara, Azevedo Ramos, Márcia, Vanusa da Silva, Maria, Tereza dos Santos Correia, Kêsia, Xisto Fonseca Ribeiro de Sena, Túlio, Diego da Silva, André, de Lima Aires, Mônica, Camelo Pessôa de Azevedo Albuquerque, Gardênia, Carmen Gadelha Militão, Teresinha, Gonçalves da Silva, Renata, Mendonça Araújo, Julianna, Ferreira Cavalcanti de Albuquerque, Rafael, Matos Ximenes

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