Search Results - "Milhollen, M"

577 Characterization of the cellular mechanism of action of the first in class investigational inhibitor of the Ubiquitin Activating Enzyme, MLN7243 by Milhollen, M, Sappal, D, Duffy, J, Hoar, K, Huck, J, Sha, P, Koenig, E, Hyer, M, Ciavarri, J, Bence, N

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The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy by Soucy, Teresa A, Dick, Lawrence R, Smith, Peter G, Milhollen, Michael A, Brownell, James E

“…Cancer cells depend on signals that promote cell cycle progression and prevent programmed cell death that would otherwise result from cumulative, aberrant…”
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561 Nonclinical characterization of the first in class investigational ubiquitin activating enzyme inhibitor MLN7243 in cellular and in vivo models of cancer in support of a phase I study by Milhollen, M, Hyer, M, Ciavarri, J, Traore, T, Sappal, D, Huck, J, Shi, J, Duffy, J, Gavin, J, Brownell, J, Yang, Y, Stringer, B, Ishii, Y, Koenig, E, Lublinsky, A, Griffin, R, Xia, C, Powe, J, Fleming, P, Bence, N

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Identification of D-Peptide Ligands Through Mirror-Image Phage Display by Ton N. M. Schumacher, Mayr, Lorenz M., Minor, Daniel L., Milhollen, Michael A., Burgess, Michael W., Kim, Peter S.

“…Genetically encoded libraries of peptides and oligonucleotides are well suited for the identification of ligands for many macromolecules. A major drawback of…”
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α-Lactalbumin forms a compact molten globule in the absence of disulfide bonds by Redfield, Christina, Schulman, Brenda A, Milhollen, Michael A, Kim, Peter S, Dobson, Christopher M

“…Human alpha-lactalbumin (alpha-LA) is a four disulfide-bonded protein that adopts partially structured conformations under a variety of mildly denaturing…”
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356 POSTER MLN4924, a potent and novel small molecule inhibitor of Nedd8 activating enzyme, induces DNA re-replication and apoptosis in cultured human tumor cells by Milhollen, M, Narayanan, U, Amidon, B, Berger, A, Langston, S, Soucy, T, Smith, P

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85 POSTER Pharmacodynamic and efficacy relationship of MLN4924, a novel small molecule inhibitor of Nedd8-activating enzyme, in human xenograft tumors grown in immunocompromised mice by Berger, A, Yu, J, Garnsey, J, Milhollen, M, Zhang, J, Traore, T, Tou, L, McDonald, A, Burke, K, Smith, P.G

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Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-Å resolution by Malashkevich, V N, Schneider, B J, McNally, M L, Milhollen, M A, Pang, J X, Kim, P S

“…Ebola virions contain a surface transmembrane glycoprotein (GP) that is responsible for binding to target cells and subsequent fusion of the viral and…”
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2-(8-hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid, a small molecule isocoumarin, potentiates dexamethasone-induced apoptosis of human multiple myeloma cells by AGATA, Naoki, NOGI, Hiroko, MILHOLLEN, Michael, KHARBANDA, Surender, KUFE, Donald

“…2-(8-Hydroxy-6-methoxy-1-oxo-1Eta-2-benzopyran-3-yl)propionic acid (NM-3) is a small molecule isocoumarin derivative that has recently entered clinical trials…”
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Antineoplastic effects of chemotherapeutic agents are potentiated by NM-3, an inhibitor of angiogenesis by REIMER, Corinne L, AGATA, Naoki, KUFE, Donald, KHARBANDA, Surender, TAMMAM, Jennifer G, BAMBERG, Michael, DICKERSON, William M, KAMPHAUS, George D, ROOK, Susan L, MILHOLLEN, Michael, FRAM, Robert, KALLURI, Raghu

“…Antiangiogenic therapy, although effective in shrinking tumors, has not yet been established as a standalone treatment for cancer. This therapeutic limitation…”
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The angiogenesis inhibitor NM-3 is active against human NSCLC xenografts alone and in combination with docetaxel by AGATA, Naoki, NOGI, Hiroko, BAMBERG, Michael, MILHOLLEN, Michael, MINYING PU, WEITMAN, Steven, KHARBANDA, Surender, KUFE, Donald

“…The novel isocoumarin 2-(8-hydroxy-6-methoxy-1-oxo-1 H-2-benzopyran-3-yl) propionic acid (NM-3) has completed phase I clinical evaluation as an orally…”
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Core Structure of the Envelope Glycoprotein GP2 from Ebola Virus at 1.9- angstrom Resolution by Malashkevich, Vladimir N., Schneider, Brian J., McNally, Margaret L., Milhollen, Michael A., Pang, James X., Kim, Peter S.

“…Ebola virions contain a surface transmembrane glycoprotein (GP) that is responsible for binding to target cells and subsequent fusion of the viral and…”
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Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-Aa resolution by Malashkevich, V N, Schneider, B J, McNally, M L, Milhollen, MA, Pang, J X, Kim, P S

“…Ebola virions contain a surface transmembrane glycoprotein (GP) that is responsible for binding to target cells and subsequent fusion of the viral and…”
Get full text