Search Results - "Milham, Luke"

Modeling sporadic Alzheimer's disease in mice by combining Apolipoprotein E4 risk gene with environmental risk factors by Ganesan, Kiruthika, Rentsch, Peggy, Langdon, Alexander, Milham, Luke T, Vissel, Bryce

“…Developing effective treatment for Alzheimer's disease (AD) remains a challenge. This can be partially attributed to the fact that the mouse models used in…”
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A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability by Konen, Lyndsey M, Wright, Amanda L, Royle, Gordon A, Morris, Gary P, Lau, Benjamin K, Seow, Patrick W, Zinn, Raphael, Milham, Luke T, Vaughan, Christopher W, Vissel, Bryce

“…Calcium (Ca )-permeable AMPA receptors may, in certain circumstances, contribute to normal synaptic plasticity or to neurodegeneration. AMPA receptors are Ca…”
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Quantification of AMPA receptor subunits and RNA editing-related proteins in the J20 mouse model of Alzheimer's disease by capillary western blotting by Milham, Luke T, Morris, Gary P, Konen, Lyndsey M, Rentsch, Peggy, Avgan, Nesli, Vissel, Bryce

“…Accurate modelling of molecular changes in Alzheimer's disease (AD) dementia is crucial for understanding the mechanisms driving neuronal pathology and for…”
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The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease by Wright, Amanda L, Konen, Lyndsey M, Mockett, Bruce G, Morris, Gary P, Singh, Anurag, Burbano, Lisseth Estefania, Milham, Luke, Hoang, Monica, Zinn, Raphael, Chesworth, Rose, Tan, Richard P, Royle, Gordon A, Clark, Ian, Petrou, Steven, Abraham, Wickliffe C, Vissel, Bryce

“…Abstract Background RNA editing at the Q/R site of GluA2 occurs with ~99% efficiency in the healthy brain, so that the majority of AMPARs contain GluA2(R)…”
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