Cytokines in Patients with Lung Cancer

Lung cancer is one of the most common malignant diseases and is amongst the leading causes of death. Cell‐mediated immune response and cytokines could play an important role in antitumour immunity. The aim of the study was to evaluate the cytokines', tumour necrosis factor‐α (TNF‐α), interleuki...

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Bibliographic Details
Published in:	Scandinavian journal of immunology Vol. 57; no. 2; pp. 173 - 178
Main Authors:	Matanić, D., Beg‐Zec, Z., Stojanović, D., Matakorić, N., Flego, V., Milevoj‐Ribić, F.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01-02-2003 Wiley Subscription Services, Inc
Subjects:	Adenocarcinoma - immunology Adenocarcinoma - metabolism Adult Aged Aged, 80 and over Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - immunology Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - metabolism Cytokines - biosynthesis Cytokines - immunology Female Humans Interleukin-1 - biosynthesis Interleukin-1 - blood Interleukin-6 - blood Interleukin-6 - immunology Lung Neoplasms - immunology Lung Neoplasms - metabolism Macrophages, Alveolar - chemistry Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Male Middle Aged Tumor Necrosis Factor-alpha - biosynthesis
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Summary:	Lung cancer is one of the most common malignant diseases and is amongst the leading causes of death. Cell‐mediated immune response and cytokines could play an important role in antitumour immunity. The aim of the study was to evaluate the cytokines', tumour necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β) and IL‐6, releasing capacity in patients with lung carcinoma and benign lung disease. A group of 41 patients were tested for the production of TNF‐α, IL‐1β and IL‐6 in bronchoalveolar lavage (BAL) and blood. The levels of cytokines in the lung cancer patients were: (1) in BAL – IL‐6, 173 ± 85 pg/ml; TNF‐α, 170 ± 116 pg/ml; and IL‐1β, 473 ± 440 pg/ml; (2) in the blood – IL‐6, 197 ± 53 pg/ml; TNF‐α, 311 ± 202 pg/ml; and IL‐1β, 915 ± 239 pg/ml. Alveolar macrophages of the patients with a lung cancer secreted significantly more cytokines, IL‐6 (P = 0.0004) and IL‐1β (P = 0.0047), than alveolar macrophages of the patients with a nonmalignant lung cancer. However, significantly lower levels of cytokine production by the BAL cells were found in patients with small cell lung cancer. This production decreased further in phase IV of nonsmall cell lung cancer.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0300-9475 1365-3083
DOI:	10.1046/j.1365-3083.2003.01205.x