Search Results - "Mileva, Izolda"

Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5 [S] by Newcomb, Benjamin, Rhein, Cosima, Mileva, Izolda, Ahmad, Rasheed, Clarke, Christopher J., Snider, Justin, Obeid, Lina M., Hannun, Yusuf A.

“…Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to produce the biologically active lipid ceramide. Previous studies have implicated ASM in the induction…”
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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice by Alsamman, Sarah, Christenson, Stephanie A, Yu, Amy, Ayad, Nadia M E, Mooring, Meghan S, Segal, Joe M, Hu, Jimmy Kuang-Hsien, Schaub, Johanna R, Ho, Steve S, Rao, Vikram, Marlow, Megan M, Turner, Scott M, Sedki, Mai, Pantano, Lorena, Ghoshal, Sarani, Ferreira, Diego Dos Santos, Ma, Hsiao-Yen, Duwaerts, Caroline C, Espanol-Suner, Regina, Wei, Lan, Newcomb, Benjamin, Mileva, Izolda, Canals, Daniel, Hannun, Yusuf A, Chung, Raymond T, Mattis, Aras N, Fuchs, Bryan C, Tager, Andrew M, Yimlamai, Dean, Weaver, Valerie M, Mullen, Alan C, Sheppard, Dean, Chen, Jennifer Y

“…Hepatic stellate cells (HSCs) drive hepatic fibrosis. Therapies that inactivate HSCs have clinical potential as antifibrotic agents. We previously identified…”
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1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase by Truman, Jean-Philip, Ruiz, Christian F., Montal, Emily, Garcia-Barros, Monica, Mileva, Izolda, Snider, Ashley J., Hannun, Yusuf A., Obeid, Lina M., Mao, Cungui

“…Cancer cells may depend on exogenous serine, depletion of which results in slower growth and activation of adaptive metabolic changes. We previously…”
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DEGS1 variant causes neurological disorder by Dolgin, Vadim, Straussberg, Rachel, Xu, Ruijuan, Mileva, Izolda, Yogev, Yuval, Khoury, Raed, Konen, Osnat, Barhum, Yael, Zvulunov, Alex, Mao, Cungui, Birk, Ohad S

“…Sphingolipidoses are monogenic lipid storage diseases caused by variants in enzymes of lipid synthesis and metabolism. We describe an autosomal recessive…”
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Peripheral fat loss and decline in adipogenesis in older humans by Caso, Giuseppe, McNurlan, Margaret A, Mileva, Izolda, Zemlyak, Alla, Mynarcik, Dennis C, Gelato, Marie C

“…Abstract Objective Aging is associated with a redistribution of body fat including a relative loss of subcutaneous peripheral fat. These changes in body fat…”
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Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis by Yu, Amy, Cable, Carson, Sharma, Sachin, Shihan, Mahbubul H., Mattis, Aras N., Mileva, Izolda, Hannun, Yusuf A., Duwaerts, Caroline C., Chen, Jennifer Y.

“…Non-alcoholic fatty liver disease (NAFLD) is a common cause of liver disease worldwide, and is characterized by the accumulation of fat in the liver…”
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Role of Glutamine Depletion in Directing Tissue-specific Nutrient Stress Responses to L-Asparaginase by Reinert, Rachel B., Oberle, L. Morgan, Wek, Sheree A., Bunpo, Piyawan, Wang, Xue Ping, Mileva, Izolda, Goodwin, Leslie O., Aldrich, Carla J., Durden, Donald L., McNurlan, Margaret A., Wek, Ronald C., Anthony, Tracy G.

“…l -Asparaginase is important in the induction regimen for treating acute lymphoblastic leukemia. Cytotoxic complications are clinically significant problems…”
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Response of albumin synthesis to oral nutrients in young and elderly subjects by Caso, Giuseppe, Feiner, Joshua, Mileva, Izolda, Bryan, Leslie J, Kelly, Patricia, Autio, Karen, Gelato, Marie C, McNurlan, Margaret A

“…BACKGROUND: The synthesis of albumin after oral ingestion of nutrients provides a means of storing amino acids, which can be made available during periods of…”
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Peripheral Sphingolipids as Potential Biomarkers of Parkinson disease Including Sex-Related Differences (P3-11.007) by Ortega, Roberto, Burbulla, Lena, Mileva, Izolda, Taylor, Graeme, Cuperlovic-Culf, Miroslava, Glickman, Amanda, Pullman, Mariel, Scherzer, Clemens, Raymond, Deborah, Miltenyi-Miltenberger, Gabriel, Yoo, Andrea, Nichols, William, Krainc, Dimitri, Bressman, Susan, Obeid, Lina, Hannun, Yusuf, Bennett, Steffany, Saunders-Pullman, Rachel

“…Abstract only…”
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Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response by Xu, Ruijuan, Wang, Kai, Mileva, Izolda, Hannun, Yusuf A, Obeid, Lina M, Mao, Cungui

“…Human cells respond to DNA damage by elevating sphingosine, a bioactive sphingolipid that induces programmed cell death (PCD) in response to various forms of…”
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Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates by Li, Fang, Xu, Ruijuan, Low, Benjamin E., Lin, Chih-Li, Garcia-Barros, Monica, Schrandt, Jennifer, Mileva, Izolda, Snider, Ashley, Luo, Catherine K., Jiang, Xian-Cheng, Li, Ming-Song, Hannun, Yusuf A., Obeid, Lina M., Wiles, Michael V., Mao, Cungui

“…ABSTRACT Sphingosine‐1‐phosphate (S1P) plays important roles in cardiovascular development and immunity. S1P is abundant in plasma because erythrocytes—the…”
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Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue by Schwartz, Nicholas U., Mileva, Izolda, Gurevich, Mikhail, Snider, Justin, Hannun, Yusuf A., Obeid, Lina M.

“…Accumulation of deoxysphingolipids (deoxySLs) has been implicated in many neural diseases, although mechanisms remain unclear. A major obstacle limiting…”
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Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function by Yi, Jae Kyo, Xu, Ruijuan, Jeong, Eunmi, Mileva, Izolda, Truman, Jean-Philip, Lin, Chih-Li, Wang, Kai, Snider, Justin, Wen, Sally, Obeid, Lina M, Hannun, Yusuf A, Mao, Cungui

“…Sphingoid bases (SBs) as bioactive sphingolipids, have been implicated in aging in yeast. However, we know neither how SBs are regulated during yeast aging nor…”
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Decline in adipogenesis contributes to peripheral subcutaneous fat loss in older humans by Caso, Giuseppe, McNurlan, Margaret A, Mileva, Izolda, Stein, Seth, Gelato, Marie C

“…Abstract only Aging is associated with redistribution of body fat characterized by a relative loss of subcutaneous limb fat and accumulation in trunk and…”
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Feeding acutely stimulates fibrinogen synthesis in healthy young and elderly adults by Caso, Giuseppe, Mileva, Izolda, Kelly, Patricia, Ahn, Hongshik, Gelato, Marie C, McNurlan, Margaret A

“…Fibrinogen is a positive acute-phase protein and its hepatic synthesis is enhanced following inflammation and injury. However, it is not clear whether…”
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Effect of ritonavir and atazanavir on human subcutaneous preadipocyte proliferation and differentiation by Caso, Giuseppe, Mileva, Izolda, Mcnurlan, Margaret A., Mynarcik, Dennis C., Darras, Frank, Gelato, Marie C.

“…Protease inhibitors (PIs) have been implicated in the development of HIV-associated lipodystrophy through a reduction in the differentiation of preadipocytes…”
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Effect of Insulin With Oral Nutrients on Whole-Body Protein Metabolism in Growing Pubertal Children With Type 1 Diabetes by Braziuniene, Ieva, Garlick, Jeremy, Mileva, Izolda, Desikan, Vardhini, Wilson, Thomas A, McNurlan, Margaret

“…Insulin treatment of children with insulin-dependent diabetes mellitus improves whole body protein balance. Our recent study, conducted in pubertal children…”
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Response of albumin synthesis to oral nutrients in young and elderly subjects1,2,3 by Caso, Giuseppe, Feiner, Joshua, Mileva, Izolda, Bryan, Leslie J

“…The synthesis of albumin after oral ingestion of nutrients provides a means of storing amino acids, which can be made available during periods of fasting. This…”
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Acute effect of oral nutrients on fibrinogen synthesis in healthy young and elderly subjects by Caso, Giuseppe, Maturi, Jyothirmayi, Mileva, Izolda, Kelly, Patricia, Ahn, Hongshik, Gelato, Marie C, McNurlan, Margaret A

“…Abstract only The hepatic synthesis of fibrinogen is stimulated following inflammation and trauma. However, it is not known if fibrinogen synthesis is…”
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Response of albumin synthesis to oral nutrients in young and elderly subjects2 by Caso, Giuseppe, Feiner, Joshua, Mileva, Izolda, Bryan, Leslie J, Kelly, Patricia, Autio, Karen, Gelato, Marie C, McNurlan, Margaret A

“…Background:The synthesis of albumin after oral ingestion of nutrients provides a means of storing amino acids, which can be made available during periods of…”
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