Search Results - "Milescu, Mirela"

Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing by Navarro, Marco A, Salari, Autoosa, Lin, Jenna L, Cowan, Luke M, Penington, Nicholas J, Milescu, Mirela, Milescu, Lorin S

“…Voltage-gated sodium channels play a critical role in cellular excitability, amplifying small membrane depolarizations into action potentials. Interactions…”
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Structural interactions of a voltage sensor toxin with lipid membranes by Mihailescu, Mihaela, Krepkiy, Dmitriy, Milescu, Mirela, Gawrisch, Klaus, Swartz, Kenton J, White, Stephen

“…Protein toxins from tarantula venom alter the activity of diverse ion channel proteins, including voltage, stretch, and ligand-activated cation channels…”
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Palmitoylation influences the function and pharmacology of sodium channels by Bosmans, Frank, Milescu, Mirela, Swartz, Kenton J

“…Palmitoylation is a common lipid modification known to regulate the functional properties of various proteins and is a vital step in the biosynthesis of…”
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Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels by Gupta, Kanchan, Zamanian, Maryam, Bae, Chanhyung, Milescu, Mirela, Krepkiy, Dmitriy, Tilley, Drew C, Sack, Jon T, Yarov-Yarovoy, Vladimir, Kim, Jae Il, Swartz, Kenton J

“…Tarantula toxins that bind to voltage-sensing domains of voltage-activated ion channels are thought to partition into the membrane and bind to the channel…”
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Structure and Orientation of a Voltage-Sensor Toxin in Lipid Membranes by Jung, Hyun Ho, Jung, Hoi Jong, Milescu, Mirela, Lee, Chul Won, Lee, Seungkyu, Lee, Ju Yeon, Eu, Young-Jae, Kim, Ha Hyung, Swartz, Kenton J., Kim, Jae Il

“…Amphipathic protein toxins from tarantula venom inhibit voltage-activated potassium (Kv) channels by binding to a critical helix-turn-helix motif termed the…”
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Regulation of the Tryptophan Biosynthetic Genes in Bacillus halodurans: Common Elements but Different Strategies than Those Used by Bacillus subtilis by SZIGETI, Reka, MILESCU, T. Mirela, GOLLNICK, Paul

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Targeting T-Type Channels with Protxii-Like Toxins by Salari, Autoosa, Milescu, Mirela

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Voltage-Sensor Pharmacology in T-Type Calcium Channels by Salari, Autoosa, Milescu, Mirela

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From Foe to Friend: Using Animal Toxins to Investigate Ion Channel Function by Kalia, Jeet, Milescu, Mirela, Salvatierra, Juan, Wagner, Jordan, Klint, Julie K., King, Glenn F., Olivera, Baldomero M., Bosmans, Frank

“…Ion channels are vital contributors to cellular communication in a wide range of organisms, a distinct feature that renders this ubiquitous family of…”
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A Model-Driven Analysis of Thermosensation Mechanisms in the Family of Ionotropic Gustatory Receptors from Drosophila Genus by Amirshenava, Marzie, Anishkin, Andriy, Mishra, Aditi, Sukharev, Sergei I., Milescu, Mirela, Milescu, Lorin S.

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Parameter Optimization for Ion Channel Models: Integrating New Data with Known Channel Properties by Navarro, Marco A, Amirshenava, Marzie, Salari, Autoosa, Milescu, Mirela, Milescu, Lorin S

“…Ion channels play a central role in membrane physiology, but to fully understand how they operate, one must have accurate kinetic mechanisms. Estimating…”
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Sodium Channels Implement a Molecular Leaky Integrator to Sense Spiking Frequency and Regulate Neuronal Firing by Navarro, Marco A., Lin, Jenna, Salari, Autoosa, Milescu, Mirela, Milescu, Lorin S.

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Estimating kinetic mechanisms with prior knowledge II: Behavioral constraints and numerical tests by Navarro, Marco A, Salari, Autoosa, Milescu, Mirela, Milescu, Lorin S

“…Kinetic mechanisms predict how ion channels and other proteins function at the molecular and cellular levels. Ideally, a kinetic model should explain new data…”
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Estimating kinetic mechanisms with prior knowledge I: Linear parameter constraints by Salari, Autoosa, Navarro, Marco A, Milescu, Mirela, Milescu, Lorin S

“…To understand how ion channels and other proteins function at the molecular and cellular levels, one must decrypt their kinetic mechanisms. Sophisticated…”
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Unlocking the gating mechanism of Kv2.1 using guangxitoxin by Navarro, Marco A, Milescu, Lorin S, Milescu, Mirela

“…Navarro et al discuss new work using the gating-modifier toxin GxTx to investigate the molecular mechanism of Kv2.1 channel gating…”
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Interactions between lipids and voltage sensor paddles detected with tarantula toxins by Milescu, Mirela, Swartz, Kenton J, Bosmans, Frank, Lee, Seungkyu, Alabi, AbdulRasheed A, Kim, Jae Il

“…Increasing evidence indicates that membrane protein function can be affected by the surrounding membrane bilayer. A new study on voltage-gated potassium…”
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Molecular Interactions between Tarantula Toxins and Low-Voltage-Activated Calcium Channels by Salari, Autoosa, Vega, Benjamin S., Milescu, Lorin S., Milescu, Mirela

“…Few gating-modifier toxins have been reported to target low-voltage-activated (LVA) calcium channels and the structural basis of toxin sensitivity remains…”
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Domain-Specific Gating-Modifier Toxins for Voltage-Gated Calcium Channels by Salari, Autoosa, Baggett, Vincent L., Milescu, Mirela

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Drosophila-Inspired Molecular Thermosensors by Amirshenava, Marzie, Zars, Benjamin, Berigan, Benton, Martinez, Paige, Zars, Troy, Milescu, Lorin S., Milescu, Mirela

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Intracellular Calcium Alters Sodium Channel Kinetics to Influence Neuronal Firing by Navarro, Marco A., Lin, Jenna L., Berigan, Benton R., Milescu, Mirela, Milescu, Lorin S.

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