Search Results - "Miles, David J.C"

The tuberculosis vaccine H4:IC31 is safe and induces a persistent polyfunctional CD4 T cell response in South African adults: A randomized controlled trial by Geldenhuys, Hennie, Mearns, Helen, Miles, David J.C, Tameris, Michele, Hokey, David, Shi, Zhongkai, Bennett, Sean, Andersen, Peter, Kromann, Ingrid, Hoff, Søren T, Hanekom, Willem A, Mahomed, Hassan, Hatherill, Mark, Scriba, Thomas J, van Rooyen, Michele, Bruce McClain, J, Ryall, Robert, de Bruyn, Guy

“…Abstract Background New, more effective vaccines to prevent tuberculosis (TB) disease are needed urgently. H4:IC31 is an investigational vaccine that contains…”
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Human immunodeficiency virus (HIV) infection during pregnancy induces CD4 T-cell differentiation and modulates responses to Bacille Calmette-Guérin (BCG) vaccine in HIV-uninfected infants by Miles, David J.C, Gadama, Louis, Gumbi, Anita, Nyalo, Flora, Makanani, Bonus, Heyderman, Robert S

“…Human immunodeficiency virus (HIV)-negative infants born to HIV-positive mothers frequently exhibit a range of immunological abnormalities. We tested the…”
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Immunological impact of an additional early measles vaccine in Gambian children: Responses to a boost at 3 years by Njie-Jobe, Jainaba, Nyamweya, Samuel, Miles, David J.C, van der Sande, Marianne, Zaman, Syed, Touray, Ebrima, Hossin, Safayet, Adetifa, Jane, Palmero, Melba, Burl, Sarah, Jeffries, David, Rowland-Jones, Sarah, Flanagan, Katie, Jaye, Assan, Whittle, Hilton

“…Highlights ► Gambian infants were given one or two doses of measles vaccine. ► The kinetics of the immune response was compared after a boost. ► Antibody…”
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effect of placental malaria infection on cord blood and maternal immunoregulatory responses at birth by Flanagan, Katie L, Halliday, Alice, Burl, Sarah, Landgraf, Katja, Jagne, Ya Jankey, Noho-Konteh, Fatou, Townend, John, Miles, David J.C, van der Sande, Marianne, Whittle, Hilton, Rowland-Jones, Sarah

“…Placental malaria (PM), a frequent infection of pregnancy, provides an ideal opportunity to investigate the impact on immune development of exposure of the…”
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Risk factors for and clinical outcome of congenital cytomegalovirus infection in a peri-urban West-African birth cohort by van der Sande, Marianne A B, Kaye, Steve, Miles, David J C, Waight, Pauline, Jeffries, David J, Ojuola, Olubukola O, Palmero, Melba, Pinder, Margaret, Ismaili, Jamila, Flanagan, Katie L, Aveika, Akum A, Zaman, Akram, Rowland-Jones, Sarah, McConkey, Samuel J, Whittle, Hilton C, Marchant, Arnaud

“…Congenital cytomegalovirus (CMV) infection is the most prevalent congenital infection worldwide. Epidemiology and clinical outcomes are known to vary with…”
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Cytomegalovirus infection induces T-cell differentiation without impairing antigen-specific responses in Gambian infants by Miles, David J.C, Sanneh, Mariama, Holder, Beth, Crozier, Sarah, Nyamweya, Samuel, Touray, Ebrima S, Palmero, Melba S, Zaman, Syed M.A, Rowland-Jones, Sarah, van der Sande, Marianne, Whittle, Hilton

“…Cytomegalovirus (CMV) infection induces profound differentiation of T cells, and is associated with impaired responses to other immune challenges. We therefore…”
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Analysis of flow cytometry data using an automatic processing tool by Jeffries, David, Zaidi, Irfan, de Jong, Bouke, Holland, Martin J, Miles, David J.C

“…In spite of recent advances in flow cytometry technology, most cytometry data is still analyzed manually which is labor-intensive for large datasets and prone…”
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Immunostimulation of striped snakehead Channa striata against epizootic ulcerative syndrome by Miles, David J.C, Polchana, Jaree, Lilley, James H, Kanchanakhan, Somkiat, Thompson, Kim D, Adams, Alexandra

“…Five immunostimulants were injected intraperitoneally into striped snakeheads ( Channa striata). The inhibitory effects of the serum and macrophages collected…”
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Defective Monocyte Enzymatic Function and an Inhibitory Immune Phenotype in Human Immunodeficiency Virus-Exposed Uninfected African Infants in the Era of Antiretroviral Therapy by Afran, Louise, Jambo, Kondwani C, Nedi, Wilfred, Miles, David J C, Kiran, Anmol, Banda, Dominic H, Kamg'ona, Ralph, Tembo, Dumizulu, Pachnio, Annette, Nastouli, Eleni, Ferne, Brigit, Mwandumba, Henry C, Moss, Paul, Goldblatt, David, Rowland-Jones, Sarah, Finn, Adam, Heyderman, Robert S

“…Human immunodeficiency virus-exposed uninfected (HEU) infants are a rapidly expanding population in sub-Saharan Africa and are highly susceptible to…”
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Early T Cell Differentiation with Well-Maintained Function across the Adult Life Course in Sub-Saharan Africa by Miles, David J C, Shumba, Florence, Pachnio, Annette, Begum, Jusnara, Corbett, Elizabeth L, Heyderman, Robert S, Moss, Paul

“…Immune senescence is a significant contributor to health problems in the developed world and may be accelerated by chronic viral infections. To date, there…”
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Cytomegalovirus Infection in Gambian Infants Leads to Profound CD8 T-Cell Differentiation by Miles, David J C, van der Sande, Marianne, Jeffries, David, Kaye, Steve, Ismaili, Jamila, Ojuola, Olubukola, Sanneh, Mariama, Touray, Ebrima S, Waight, Pauline, Rowland-Jones, Sarah, Whittle, Hilton, Marchant, Arnaud

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Impaired CD4 T cell memory response to Streptococcus pneumoniae precedes CD4 T cell depletion in HIV-infected Malawian adults by Glennie, Sarah J, Sepako, Enoch, Mzinza, David, Harawa, Visopo, Miles, David J C, Jambo, Kondwani C, Gordon, Stephen B, Williams, Neil A, Heyderman, Robert S

“…Invasive pneumococcal disease (IPD) is a leading cause of morbidity and mortality in HIV-infected African adults. CD4 T cell depletion may partially explain…”
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Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants by Holder, Beth, Miles, David J C, Kaye, Steve, Crozier, Sarah, Mohammed, Nuredin Ibrahim, Duah, Nancy O, Roberts, Elishia, Ojuola, Olubukola, Palmero, Melba S, Touray, Ebrima S, Waight, Pauline, Cotten, Matthew, Rowland-Jones, Sarah, van der Sande, Marianne, Whittle, Hilton

“…Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are persistent herpesviruses that have various immunomodulatory effects on their hosts. Both viruses are…”
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Maintenance of large subpopulations of differentiated CD8 T-cells two years after cytomegalovirus infection in Gambian infants by Miles, David J C, van der Sande, Marianne, Jeffries, David, Kaye, Steve, Ojuola, Olubukola, Sanneh, Mariama, Cox, Momodou, Palmero, Melba S, Touray, Ebrima S, Waight, Pauline, Rowland-Jones, Sarah, Whittle, Hilton, Marchant, Arnaud

“…In a previously published study, we found that large differentiated subpopulations of CD8 T-cells emerged rapidly after CMV infection in young infants and…”
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CD4+ T Cell Responses to Cytomegalovirus in Early Life: A Prospective Birth Cohort Study by Miles, David J. C., van der Sande, Marianne, Kaye, Steve, Crozier, Sarah, Ojuola, Olubukola, Palmero, Melba S., Sanneh, Mariama, Touray, Ebrima S., Waight, Pauline, Rowland-Jones, Sarah, Whittle, Hilton, Marchant, Arnaud

“…We compared cytomegalovirus (CMV)—specific interferon-γ (IFN-γ), interleukin 2 (IL—2), and CD154 CD4+ T cell responses of infants to those from chronically…”
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Placental malaria is associated with attenuated CD4 T-cell responses to tuberculin PPD 12 months after BCG vaccination by Walther, Brigitte, Miles, David J C, Waight, Pauline, Palmero, Melba S, Ojuola, Olubukola, Touray, Ebrima S, Whittle, Hilton, van der Sande, Marianne, Crozier, Sarah, Flanagan, Katie L

“…Placental malaria (PM) is associated with prenatal malaise, but many PM+ infants are born without symptoms. As malaria has powerful immunomodulatory effects,…”
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Effects of Antenatal and Postnatal Environments on CD4 T-Cell Responses to Mycobacterium bovis BCG in Healthy Infants in The Gambia by Miles, David J C, van der Sande, Marianne, Crozier, Sarah, Ojuola, Olubukola, Palmero, Melba S, Sanneh, Mariama, Touray, Ebrima S, Rowland-Jones, Sarah, Whittle, Hilton, Ota, Martin, Marchant, Arnaud

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Immunofluorescence of the epizootic ulcerative syndrome pathogen, Aphanomyces invadans, using a monoclonal antibody by MILES, David J. C, THOMPSON, Kim D, LILLEY, James H, ADAMS, Alexandra

“…A monoclonal antibody (MAb), designated 3gJC9, was raised against a protein antigen of Aphanomyces invadans, the oomycete pathogen that causes epizootic…”
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Effect of macrophages and serum of fish susceptible or resistant to epizootic ulcerative syndrome (EUS) on the EUS pathogen, Aphanomyces invadans by Miles, David J.C., Kanchanakhan, Somkiat, Lilley, James H., Thompson, Kim D., Chinabut, Supranee, Adams, Alexandra

“…Epizootic ulcerative syndrome (EUS) is one of the most destructive diseases of fresh and brackish water farmed and wild fish in the Asia–Pacific region. The in…”
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