Search Results - "Milek, Miha"

The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts by Baltz, Alexander G., Munschauer, Mathias, Schwanhäusser, Björn, Vasile, Alexandra, Murakawa, Yasuhiro, Schueler, Markus, Youngs, Noah, Penfold-Brown, Duncan, Drew, Kevin, Milek, Miha, Wyler, Emanuel, Bonneau, Richard, Selbach, Matthias, Dieterich, Christoph, Landthaler, Markus

“…Protein-RNA interactions are fundamental to core biological processes, such as mRNA splicing, localization, degradation, and translation. We developed a…”
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Phosphorylation of the Ribosomal Protein RPL12/uL11 Affects Translation during Mitosis by Imami, Koshi, Milek, Miha, Bogdanow, Boris, Yasuda, Tomoharu, Kastelic, Nicolai, Zauber, Henrik, Ishihama, Yasushi, Landthaler, Markus, Selbach, Matthias

“…Emerging evidence indicates that heterogeneity in ribosome composition can give rise to specialized functions. Until now, research mainly focused on…”
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The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay by Silla, Toomas, Schmid, Manfred, Dou, Yuhui, Garland, William, Milek, Miha, Imami, Koshi, Johnsen, Dennis, Polak, Patrik, Andersen, Jens S, Selbach, Matthias, Landthaler, Markus, Jensen, Torben Heick

“…Abstract Recruitment of the human ribonucleolytic RNA exosome to nuclear polyadenylated (pA+) RNA is facilitated by the Poly(A) Tail eXosome Targeting (PAXT)…”
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HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins by Zinnall, Ulrike, Milek, Miha, Minia, Igor, Vieira-Vieira, Carlos H., Müller, Simon, Mastrobuoni, Guido, Hazapis, Orsalia-Georgia, Del Giudice, Simone, Schwefel, David, Bley, Nadine, Voigt, Franka, Chao, Jeffrey A., Kempa, Stefan, Hüttelmaier, Stefan, Selbach, Matthias, Landthaler, Markus

“…The biological role of RNA-binding proteins in the secretory pathway is not well established. Here, we describe that human HDLBP/Vigilin directly interacts…”
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Loss of m1acp3Ψ Ribosomal RNA Modification Is a Major Feature of Cancer by Babaian, Artem, Rothe, Katharina, Girodat, Dylan, Minia, Igor, Djondovic, Sara, Milek, Miha, Spencer Miko, Sandra E., Wieden, Hans-Joachim, Landthaler, Markus, Morin, Gregg B., Mager, Dixie L.

“…The ribosome is an RNA-protein complex that is essential for translation in all domains of life. The structural and catalytic core of the ribosome is its…”
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Robust detection of clinically relevant features in single-cell RNA profiles of patient-matched fresh and formalin-fixed paraffin-embedded (FFPE) lung cancer tissue by Trinks, Alexandra, Milek, Miha, Beule, Dieter, Kluge, Julie, Florian, Stefan, Sers, Christine, Horst, David, Morkel, Markus, Bischoff, Philip

“…Purpose Single-cell transcriptional profiling reveals cell heterogeneity and clinically relevant traits in intra-operatively collected patient-derived tissue…”
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Transcriptome-wide analysis of protein–RNA interactions using high-throughput sequencing by Milek, Miha, Wyler, Emanuel, Landthaler, Markus

“…► Next-generation sequencing allows transcriptome-wide insights into protein–RNA interactions. ► Different CLIP approaches define sites of protein–RNA contacts…”
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Clinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung by Dörner, Patrick J., Anandakumar, Harithaa, Röwekamp, Ivo, Fiocca Vernengo, Facundo, Millet Pascual-Leone, Belén, Krzanowski, Marta, Sellmaier, Josua, Brüning, Ulrike, Fritsche-Guenther, Raphaela, Pfannkuch, Lennart, Kurth, Florian, Milek, Miha, Igbokwe, Vanessa, Löber, Ulrike, Gutbier, Birgitt, Holstein, Markus, Heinz, Gitta Anne, Mashreghi, Mir-Farzin, Schulte, Leon N., Klatt, Ann-Brit, Caesar, Sandra, Wienhold, Sandra-Maria, Offermanns, Stefan, Mack, Matthias, Witzenrath, Martin, Jordan, Stefan, Beule, Dieter, Kirwan, Jennifer A., Forslund, Sofia K., Wilck, Nicola, Bartolomaeus, Hendrik, Heimesaat, Markus M., Opitz, Bastian

“…Hospital-acquired pneumonia (HAP) is associated with high mortality and costs, and frequently caused by multidrug-resistant (MDR) bacteria. Although prior…”
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CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs by Xiao, Han, Wyler, Emanuel, Milek, Miha, Grewe, Bastian, Kirchner, Philipp, Ekici, Arif, Silva, Ana Beatriz Oliveira Villela, Jungnickl, Doris, Full, Florian, Thomas, Marco, Landthaler, Markus, Ensser, Armin, Überla, Klaus

“…The HIV-1 Rev protein is a nuclear export factor for unspliced and incompletely spliced HIV-1 RNAs. Without Rev, these intron-retaining RNAs are trapped in the…”
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Association of ITPA genotype with event-free survival and relapse rates in children with acute lymphoblastic leukemia undergoing maintenance therapy by Smid, Alenka, Karas-Kuzelicki, Natasa, Milek, Miha, Jazbec, Janez, Mlinaric-Rascan, Irena

“…Although the treatment of acute lymphoblastic leukemia (ALL) has improved significantly over recent decades, failure due to treatment-related toxicities and…”
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Systematic Detection of Poly(A) + RNA-Interacting Proteins and Their Differential Binding by Milek, Miha, Landthaler, Markus

“…RNA-binding proteins are dynamic posttranscriptional regulators of gene expression. Identification of mRNA-binding proteins in a given experimental setting is…”
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Subcellular mRNA kinetic modeling reveals nuclear retention as rate-limiting by Steinbrecht, David, Minia, Igor, Milek, Miha, Meisig, Johannes, Blüthgen, Nils, Landthaler, Markus

“…Eukaryotic mRNAs are transcribed, processed, translated, and degraded in different subcellular compartments. Here, we measured mRNA flow rates between…”
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Tu1750 RESPONSE TO ETRASIMOD TREATMENT IN ULCERATIVE COLITIS IS ASSOCIATED WITH A REDUCTION OF CIRCULATING B- AND PRO-INFLAMMATORY T CELLS: A SINGLE-CELL-BASED POST-HOC SUBANALYSIS OF THE ELEVATE UC 52 TRIAL by Weidinger, Carl, Milek, Miha, Hecker, Julia, Haag, Lea-Maxie, Freise, Inka, Obermayer, Benedikt, Beule, Dieter, Ryan, Rathi D., Crosby, Catherine, Siegmund, Britta

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DDX54 regulates transcriptome dynamics during DNA damage response by Milek, Miha, Imami, Koshi, Mukherjee, Neelanjan, Bortoli, Francesca De, Zinnall, Ulrike, Hazapis, Orsalia, Trahan, Christian, Oeffinger, Marlene, Heyd, Florian, Ohler, Uwe, Selbach, Matthias, Landthaler, Markus

“…The cellular response to genotoxic stress is mediated by a well-characterized network of DNA surveillance pathways. The contribution of post-transcriptional…”
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Transcriptome analysis reveals involvement of thiopurine S-methyltransferase in oxidation-reduction processes by Šmid, Alenka, Štajdohar, Miha, Milek, Miha, Urbančič, Dunja, Karas Kuželički, Nataša, Tamm, Riin, Metspalu, Andres, Mlinarič-Raščan, Irena

“…Thiopurine S-methyltransferase (TPMT) is an important enzyme involved in the deactivation of thiopurines and represents a major determinant of…”
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Expanding the map of protein-RNA interaction sites via cell fusion followed by PAR-CLIP by Hinze, Florian, Drewe-Boss, Philipp, Milek, Miha, Ohler, Uwe, Landthaler, Markus, Gotthardt, Michael

“…PAR-CLIP (photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation) facilitates the identification and mapping of protein/RNA…”
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mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons by Loedige, Inga, Baranovskii, Artem, Mendonsa, Samantha, Dantsuji, Sayaka, Popitsch, Niko, Breimann, Laura, Zerna, Nadja, Cherepanov, Vsevolod, Milek, Miha, Ameres, Stefan, Chekulaeva, Marina

“…For cells to perform their biological functions, they need to adopt specific shapes and form functionally distinct subcellular compartments. This is achieved…”
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mRNA stability and m 6 A are major determinants of subcellular mRNA localization in neurons by Loedige, Inga, Baranovskii, Artem, Mendonsa, Samantha, Dantsuji, Sayaka, Popitsch, Niko, Breimann, Laura, Zerna, Nadja, Cherepanov, Vsevolod, Milek, Miha, Ameres, Stefan, Chekulaeva, Marina

“…For cells to perform their biological functions, they need to adopt specific shapes and form functionally distinct subcellular compartments. This is achieved…”
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MTHFR and TYMS genotypes influence TPMT activity and its differential modulation in males and females by Karas-Kuzelicki, Natasa, Milek, Miha, Mlinaric-Rascan, Irena

“…TPMT catalyzes the deactivation of the cytostatic drug 6-mercaptopurine used in treatment of cancer. Patients with low levels of TPMT more often experience…”
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S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts by Milek, Miha, Kuzelicki, Natasa Karas, Smid, Alenka, Mlinaric-Rascan, Irena

“…Six-mercaptopurine (6-MP) is a pro-drug widely used in treatment of various diseases, including acute lymphoblastic leukaemia (ALL). Side-effects of thiopurine…”
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