Search Results - "Milde, Till"

HDAC family: What are the cancer relevant targets? by Witt, Olaf, Deubzer, Hedwig E, Milde, Till, Oehme, Ina

“…Abstract Histone deacetylases comprise a family of 18 genes, which are grouped into classes I–IV based on their homology to their respective yeast orthologues…”
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Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience by Capper, David, Stichel, Damian, Sahm, Felix, Jones, David T. W., Schrimpf, Daniel, Sill, Martin, Schmid, Simone, Hovestadt, Volker, Reuss, David E., Koelsche, Christian, Reinhardt, Annekathrin, Wefers, Annika K., Huang, Kristin, Sievers, Philipp, Ebrahimi, Azadeh, Schöler, Anne, Teichmann, Daniel, Koch, Arend, Hänggi, Daniel, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Witt, Olaf, Milde, Till, Korshunov, Andrey, Pfister, Stefan M., von Deimling, Andreas

“…Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation…”
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Risk stratification of childhood medulloblastoma in the molecular era: the current consensus by Ramaswamy, Vijay, Remke, Marc, Bouffet, Eric, Bailey, Simon, Clifford, Steven C., Doz, Francois, Kool, Marcel, Dufour, Christelle, Vassal, Gilles, Milde, Till, Witt, Olaf, von Hoff, Katja, Pietsch, Torsten, Northcott, Paul A., Gajjar, Amar, Robinson, Giles W., Padovani, Laetitia, André, Nicolas, Massimino, Maura, Pizer, Barry, Packer, Roger, Rutkowski, Stefan, Pfister, Stefan M., Taylor, Michael D., Pomeroy, Scott L.

“…Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological variables pertaining to age, presence of metastases, extent…”
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Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets by Sahm, Felix, Schrimpf, Daniel, Jones, David T. W., Meyer, Jochen, Kratz, Annekathrin, Reuss, David, Capper, David, Koelsche, Christian, Korshunov, Andrey, Wiestler, Benedikt, Buchhalter, Ivo, Milde, Till, Selt, Florian, Sturm, Dominik, Kool, Marcel, Hummel, Manuela, Bewerunge-Hudler, Melanie, Mawrin, Christian, Schüller, Ulrich, Jungk, Christine, Wick, Antje, Witt, Olaf, Platten, Michael, Herold-Mende, Christel, Unterberg, Andreas, Pfister, Stefan M., Wick, Wolfgang, von Deimling, Andreas

“…With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the need for comprehensive molecular analysis of…”
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Response to trametinib treatment in progressive pediatric low-grade glioma patients by Selt, Florian, van Tilburg, Cornelis M., Bison, Brigitte, Sievers, Philipp, Harting, Inga, Ecker, Jonas, Pajtler, Kristian W., Sahm, Felix, Bahr, Annabelle, Simon, Michèle, Jones, David T. W., Well, Lennart, Mautner, Victor-Felix, Capper, David, Hernáiz Driever, Pablo, Gnekow, Astrid, Pfister, Stefan M., Witt, Olaf, Milde, Till

“…Introduction A hallmark of pediatric low-grade glioma (pLGG) is aberrant signaling of the mitogen activated protein kinase (MAPK) pathway. Hence, inhibition of…”
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Safety and efficacy of mTOR inhibitor treatment in patients with tuberous sclerosis complex under 2 years of age - a multicenter retrospective study by Saffari, Afshin, Brösse, Ines, Wiemer-Kruel, Adelheid, Wilken, Bernd, Kreuzaler, Paula, Hahn, Andreas, Bernhard, Matthias K, van Tilburg, Cornelis M, Hoffmann, Georg F, Gorenflo, Matthias, Hethey, Sven, Kaiser, Olaf, Kölker, Stefan, Wagner, Robert, Witt, Olaf, Merkenschlager, Andreas, Möckel, Andreas, Roser, Timo, Schlump, Jan-Ulrich, Serfling, Antje, Spiegler, Juliane, Milde, Till, Ziegler, Andreas, Syrbe, Steffen

“…Tuberous sclerosis complex (TSC) is a multisystem disease with prominent neurologic manifestations such as epilepsy, cognitive impairment and autism spectrum…”
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Histone deacetylase 10 promotes autophagy-mediated cell survival by Oehme, Ina, Linke, Jan-Peter, Böck, Barbara C, Milde, Till, Lodrini, Marco, Hartenstein, Bettina, Wiegand, Inga, Eckert, Christian, Roth, Wilfried, Kool, Marcel, Kaden, Sylvia, Gröne, Hermann-Josef, Schulte, Johannes H, Lindner, Sven, Hamacher-Brady, Anne, Brady, Nathan R, Deubzer, Hedwig E, Witt, Olaf

“…Tumor cells activate autophagy in response to chemotherapy-induced DNA damage as a survival program to cope with metabolic stress. Here, we provide in vitro…”
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Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice by Lee, Francis S, Rafii, Shahin, Shmelkov, Sergey V, Hormigo, Adília, Jing, Deqiang, Proenca, Catia C, Bath, Kevin G, Milde, Till, Shmelkov, Evgeny, Kushner, Jared S, Baljevic, Muhamed, Dincheva, Iva, Murphy, Andrew J, Valenzuela, David M, Gale, Nicholas W, Yancopoulos, George D, Ninan, Ipe

“…Obsessive-compulsive disorder (OCD) is a common psychiatric disorder defined by the presence of obsessive thoughts and repetitive compulsive actions, and it…”
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Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B by Deng, Maximilian Y., Sturm, Dominik, Pfaff, Elke, Sill, Martin, Stichel, Damian, Balasubramanian, Gnana Prakash, Tippelt, Stephan, Kramm, Christof, Donson, Andrew M., Green, Adam L., Jones, Chris, Schittenhelm, Jens, Ebinger, Martin, Schuhmann, Martin U., Jones, Barbara C., van Tilburg, Cornelis M., Wittmann, Andrea, Golanov, Andrey, Ryzhova, Marina, Ecker, Jonas, Milde, Till, Witt, Olaf, Sahm, Felix, Reuss, David, Sumerauer, David, Zamecnik, Josef, Korshunov, Andrey, von Deimling, Andreas, Pfister, Stefan M., Jones, David T. W.

“…Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in…”
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HDAC5 and HDAC9 in Medulloblastoma: Novel Markers for Risk Stratification and Role in Tumor Cell Growth by MILDE, Till, OEHME, Ina, PFISTER, Stefan, WITT, Olaf, KORSHUNOV, Andrey, KOPP-SCHNEIDER, Annette, REMKE, Marc, NORTHCOTT, Paul, DEUBZER, Hedwig E, LODRINI, Marco, TAYLOR, Michael D, VON DEIMLING, Andreas

“…Medulloblastomas are the most common malignant brain tumors in childhood. Survivors suffer from high morbidity because of therapy-related side effects. Thus,…”
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Molecular Staging of Intracranial Ependymoma in Children and Adults by Korshunov, Andrey, Witt, Hendrik, Hielscher, Thomas, Benner, Axel, Remke, Marc, Ryzhova, Marina, Milde, Till, Bender, Sebastian, Wittmann, Andrea, Schöttler, Anna, Kulozik, Andreas E, Witt, Olaf, von Deimling, Andreas, Lichter, Peter, Pfister, Stefan

“…The biologic behavior of intracranial ependymoma is unpredictable on the basis of current staging approaches. We aimed at the identification of recurrent…”
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Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions by Stichel, Damian, Schrimpf, Daniel, Casalini, Belén, Meyer, Jochen, Wefers, Annika K., Sievers, Philipp, Korshunov, Andrey, Koelsche, Christian, Reuss, David E., Reinhardt, Annekathrin, Ebrahimi, Azadeh, Fernández-Klett, Francisco, Kessler, Tobias, Sturm, Dominik, Ecker, Jonas, Milde, Till, Herold-Mende, Christel, Witt, Olaf, Pfister, Stefan M., Wick, Wolfgang, Jones, David T. W., von Deimling, Andreas, Sahm, Felix

“…Molecular markers have become pivotal in brain tumor diagnostics. Mutational analyses by targeted next-generation sequencing of DNA and array-based DNA…”
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GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types by Sievers, Philipp, Stichel, Damian, Sill, Martin, Schrimpf, Daniel, Sturm, Dominik, Selt, Florian, Ecker, Jonas, Kazdal, Daniel, Miele, Evelina, Kranendonk, Mariëtte E. G., Tops, Bastiaan B. J., Kohlhof-Meinecke, Patricia, Beschorner, Rudi, Kramm, Christof M., Hasselblatt, Martin, Reifenberger, Guido, Capper, David, Wesseling, Pieter, Stenzinger, Albrecht, Milde, Till, Korshunov, Andrey, Witt, Olaf, Pfister, Stefan M., Wick, Wolfgang, von Deimling, Andreas, Jones, David T. W., Sahm, Felix

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Predisposition to cancer in children and adolescents by Kratz, Christian P, Jongmans, Marjolijn C, Cavé, Hélène, Wimmer, Katharina, Behjati, Sam, Guerrini-Rousseau, Lea, Milde, Till, Pajtler, Kristian W, Golmard, Lisa, Gauthier-Villars, Marion, Jewell, Rosalyn, Duncan, Catriona, Maher, Eamonn R, Brugieres, Laurence, Pritchard-Jones, Kathy, Bourdeaut, Franck

“…Childhood malignancies are rarely related to known environmental exposures, and it has become increasingly evident that inherited genetic factors play a…”
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Systemic chemotherapy of pediatric recurrent ependymomas: results from the German HIT-REZ studies by Adolph, Jonas E., Fleischhack, Gudrun, Gaab, Christine, Mikasch, Ruth, Mynarek, Martin, Rutkowski, Stefan, Schüller, Ulrich, Pfister, Stefan M., Pajtler, Kristian W., Milde, Till, Witt, Olaf, Bison, Brigitte, Warmuth-Metz, Monika, Kortmann, Rolf-Dieter, Dietzsch, Stefan, Pietsch, Torsten, Timmermann, Beate, Tippelt, Stephan

“…Purpose Survival in recurrent ependymoma (EPN) depends mainly on the extent of resection achieved. When complete resection is not feasible, chemotherapy is…”
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MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma by Lodrini, Marco, Oehme, Ina, Schroeder, Christina, Milde, Till, Schier, Marie C, Kopp-Schneider, Annette, Schulte, Johannes H, Fischer, Matthias, De Preter, Katleen, Pattyn, Filip, Castoldi, Mirco, Muckenthaler, Martina U, Kulozik, Andreas E, Westermann, Frank, Witt, Olaf, Deubzer, Hedwig E

“…MYCN is a master regulator controlling many processes necessary for tumor cell survival. Here, we unravel a microRNA network that causes tumor suppressive…”
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Germline biallelic BRCA2 pathogenic variants and medulloblastoma: an international cohort study by Kastellan, Svenja, Kalb, Reinhard, Sajjad, Bia, McReynolds, Lisa J, Giri, Neelam, Samuel, David, Milde, Till, Elbracht, Miriam, Holzhauer, Susanne, Niewisch, Marena R, Kratz, Christian P

“…Constitutional heterozygous pathogenic variants in genes coding for some components of the Fanconi anemia-BRCA signaling pathway, which repairs DNA interstrand…”
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Rapid In Vivo Validation of HDAC Inhibitor-Based Treatments in Neuroblastoma Zebrafish Xenografts by Wrobel, Jagoda K, Najafi, Sara, Ayhan, Simay, Gatzweiler, Charlotte, Krunic, Damir, Ridinger, Johannes, Milde, Till, Westermann, Frank, Peterziel, Heike, Meder, Benjamin, Distel, Martin, Witt, Olaf, Oehme, Ina

“…The survival rate among children with relapsed neuroblastomas continues to be poor, and thus new therapeutic approaches identified by reliable preclinical drug…”
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INFORM2 NivEnt: The first trial of the INFORM2 biomarker driven phase I/II trial series: the combination of nivolumab and entinostat in children and adolescents with refractory high-risk malignancies by van Tilburg, Cornelis M, Witt, Ruth, Heiss, Melanie, Pajtler, Kristian W, Plass, Christoph, Poschke, Isabel, Platten, Michael, Harting, Inga, Sedlaczek, Oliver, Freitag, Angelika, Meyrath, David, Taylor, Lenka, Balasubramanian, Gnana Prakash, Jäger, Natalie, Pfaff, Elke, Jones, Barbara C, Milde, Till, Pfister, Stefan M, Jones, David T W, Kopp-Schneider, Annette, Witt, Olaf

“…Pediatric patients with relapsed or refractory disease represent a population with a desperate medical need. The aim of the INFORM (INdividualized Therapy FOr…”
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Group-specific cellular metabolism in Medulloblastoma by Funke, Viktoria L E, Walter, Carolin, Melcher, Viktoria, Wei, Lanying, Sandmann, Sarah, Hotfilder, Marc, Varghese, Julian, Jäger, Natalie, Kool, Marcel, Jones, David T W, Pfister, Stefan M, Milde, Till, Mynarek, Martin, Rutkowski, Stefan, Seggewiss, Jochen, Jeising, Daniela, de Faria, Flavia W, Marquardt, Thorsten, Albert, Thomas K, Schüller, Ulrich, Kerl, Kornelius

“…Cancer metabolism influences multiple aspects of tumorigenesis and causes diversity across malignancies. Although comprehensive research has extended our…”
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