Search Results - "Milardi, Danilo"

Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes by Milardi, Danilo, Gazit, Ehud, Radford, Sheena E, Xu, Yong, Gallardo, Rodrigo U, Caflisch, Amedeo, Westermark, Gunilla T, Westermark, Per, Rosa, Carmelo La, Ramamoorthy, Ayyalusamy

“…The possible link between hIAPP accumulation and β-cell death in diabetic patients has inspired numerous studies focusing on amyloid structures and aggregation…”
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Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases by Lanza, Valeria, Milardi, Danilo, Di Natale, Giuseppe, Pappalardo, Giuseppe

“…There is mounting urgency to find new drugs for the treatment of neurodegenerative disorders. A large number of reviews have exhaustively described either the…”
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Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins by Sciacca, Michele F, Lolicato, Fabio, Tempra, Carmelo, Scollo, Federica, Sahoo, Bikash R, Watson, Matthew D, García-Viñuales, Sara, Milardi, Danilo, Raudino, Antonio, Lee, Jennifer C, Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

“…An increasing number of human diseases has been shown to be linked to aggregation and amyloid formation by intrinsically disordered proteins (IDPs). Amylin,…”
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Aβ and Tau Interact with Metal Ions, Lipid Membranes and Peptide-Based Amyloid Inhibitors: Are These Common Features Relevant in Alzheimer’s Disease? by Di Natale, Giuseppe, Sabatino, Giuseppina, Sciacca, Michele Francesco Maria, Tosto, Rita, Milardi, Danilo, Pappalardo, Giuseppe

“…In the last two decades, the amyloid hypothesis, i.e., the abnormal accumulation of toxic Aβ assemblies in the brain, has been considered the mainstream…”
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The Role of Cholesterol in Driving IAPP-Membrane Interactions by Sciacca, Michele F.M., Lolicato, Fabio, Di Mauro, Giacomo, Milardi, Danilo, D’Urso, Luisa, Satriano, Cristina, Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

“…Our knowledge of the molecular events underlying type 2 diabetes mellitus—a protein conformational disease characterized by the aggregation of islet amyloid…”
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Insulin Has Multiple Antiamyloidogenic Effects on Human Neuronal Cells by Pandini, Giuseppe, Pace, Vincenza, Copani, Agata, Squatrito, Sebastiano, Milardi, Danilo, Vigneri, Riccardo

“…Alzheimer's disease is increased in diabetic patients. A defective insulin activity on the brain has been hypothesized to contribute to the neuronal cell…”
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Exploring the therapeutic potential of Aloin: unraveling neuroprotective and anticancer mechanisms, and strategies for enhanced stability and delivery by Zimbone, Stefania, Romanucci, Valeria, Zarrelli, Armando, Giuffrida, Maria Laura, Sciacca, Michele F. M., Lanza, Valeria, Campagna, Tiziana, Maugeri, Ludovica, Petralia, Salvatore, Consoli, Grazia Maria Letizia, Di Fabio, Giovanni, Milardi, Danilo

“…We investigate the therapeutic potential of Aloin A and Aloin B, two natural compounds derived from Aloe vera leaves, focusing on their neuroprotective and…”
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Symmetry-breaking transitions in the early steps of protein self-assembly by La Rosa, Carmelo, Condorelli, Marcello, Compagnini, Giuseppe, Lolicato, Fabio, Milardi, Danilo, Do, Trang Nhu, Karttunen, Mikko, Pannuzzo, Martina, Ramamoorthy, Ayyalusamy, Fraternali, Franca, Collu, Francesca, Rezaei, Human, Strodel, Birgit, Raudino, Antonio

“…Protein misfolding and subsequent self-association are complex, intertwined processes, resulting in development of a heterogeneous population of aggregates…”
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The change of conditions does not affect Ros87 downhill folding mechanism by Grazioso, Rinaldo, García-Viñuales, Sara, D’Abrosca, Gianluca, Baglivo, Ilaria, Pedone, Paolo Vincenzo, Milardi, Danilo, Fattorusso, Roberto, Isernia, Carla, Russo, Luigi, Malgieri, Gaetano

“…Downhill folding has been defined as a unique thermodynamic process involving a conformations ensemble that progressively loses structure with the decrease of…”
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Identification of a novel adiponectin receptor and opioid receptor dual acting agonist as a potential treatment for diabetic neuropathy by Ma, Oscar Ka-Fai, Ronsisvalle, Simone, Basile, Livia, Xiang, Ariya Weiman, Tomasella, Cristina, Sipala, Federica, Pappalardo, Matteo, Chan, Koon-Ho, Milardi, Danilo, Ng, Roy Chun-Laam, Guccione, Salvatore

“…Diabetic neuropathy (DN) is a long-term complication of diabetes mellitus, affecting different periphery nerve systems including sensory and motor neurons…”
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Cations as Switches of Amyloid-Mediated Membrane Disruption Mechanisms: Calcium and IAPP by Sciacca, Michele F.M., Milardi, Danilo, Messina, Grazia M.L., Marletta, Giovanni, Brender, Jeffrey R., Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

“…Disruption of the integrity of the plasma membrane by amyloidogenic proteins is linked to the pathogenesis of a number of common age-related diseases. Although…”
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Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study by Santoro, Anna Maria, Monaco, Irene, Attanasio, Francesco, Lanza, Valeria, Pappalardo, Giuseppe, Tomasello, Marianna Flora, Cunsolo, Alessandra, Rizzarelli, Enrico, De Luigi, Ada, Salmona, Mario, Milardi, Danilo

“…Due to their altered metabolism cancer cells are more sensitive to proteasome inhibition or changes of copper levels than normal cells. Thus, the development…”
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Substitution of the Native Zn(II) with Cd(II), Co(II) and Ni(II) Changes the Downhill Unfolding Mechanism of Ros87 to a Completely Different Scenario by Grazioso, Rinaldo, García-Viñuales, Sara, Russo, Luigi, D'Abrosca, Gianluca, Esposito, Sabrina, Zaccaro, Laura, Iacovino, Rosa, Milardi, Danilo, Fattorusso, Roberto, Malgieri, Gaetano, Isernia, Carla

“…The structural effects of zinc replacement by xenobiotic metal ions have been widely studied in several eukaryotic and prokaryotic zinc-finger-containing…”
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Carnosine Inhibits Aβ42 Aggregation by Perturbing the H-Bond Network in and around the Central Hydrophobic Cluster by Attanasio, Francesco, Convertino, Marino, Magno, Andrea, Caflisch, Amedeo, Corazza, Alessandra, Haridas, Haritha, Esposito, Gennaro, Cataldo, Sebastiano, Pignataro, Bruno, Milardi, Danilo, Rizzarelli, Enrico

“…Aggregation of the amyloid‐β peptide (Aβ) into fibrillar structures is a hallmark of Alzheimer's disease. Thus, preventing self‐assembly of the Aβ peptide is…”
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Amyloid-Mediated Mechanisms of Membrane Disruption by Sciacca, Michele F. M., La Rosa, Carmelo, Milardi, Danilo

“…Protein aggregation and amyloid formation are pathogenic events underlying the development of an increasingly large number of human diseases named…”
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Cooperative Binding of the Cationic Porphyrin Tris-T4 Enhances Catalytic Activity of 20S Proteasome Unveiling a Complex Distribution of Functional States by Santoro, Anna Maria, D'Urso, Alessandro, Cunsolo, Alessandra, Milardi, Danilo, Purrello, Roberto, Sbardella, Diego, Tundo, Grazia R, Diana, Donatella, Fattorusso, Roberto, Dato, Antonio Di, Paladino, Antonella, Persico, Marco, Coletta, Massimo, Fattorusso, Caterina

“…The present study provides new evidence that cationic porphyrins may be considered as tunable platforms to interfere with the structural "key code" present on…”
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Sequential application of ligand and structure based modeling approaches to index chemicals for their hH4R antagonism by Pappalardo, Matteo, Shachaf, Nir, Basile, Livia, Milardi, Danilo, Zeidan, Mouhammed, Raiyn, Jamal, Guccione, Salvatore, Rayan, Anwar

“…The human histamine H4 receptor (hH4R), a member of the G-protein coupled receptors (GPCR) family, is an increasingly attractive drug target. It plays a key…”
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Fraisinib: a calixpyrrole derivative reducing A549 cell-derived NSCLC tumor in vivo acts as a ligand of the glycine-tRNA synthase, a new molecular target in oncology by Ben Toumia, Iméne, Bachetti, Tiziana, Chekir-Ghedira, Leila, Profumo, Aldo, Ponassi, Marco, Di Domizio, Alessandro, Izzotti, Alberto, Sciacca, Salvatore, Puglisi, Caterina, Forte, Stefano, Giuffrida, Raffaella, Colarossi, Cristina, Milardi, Danilo, Grasso, Giuseppe, Lanza, Valeria, Fiordoro, Stefano, Drago, Giacomo, Tkachenko, Kateryna, Cardinali, Barbara, Romano, Paolo, Iervasi, Erika, Vargas, Gabriela Coronel, Barboro, Paola, Kohnke, Franz Heinrich, Rosano, Camillo

“…Lung cancer is the leading cause of death in both men and women, constituting a major public health problem worldwide. Non-small-cell lung cancer accounts for…”
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The Ionophoric Activity of a Pro-Apoptotic VEGF165 Fragment on HUVEC Cells by Zimbone, Stefania, Santoro, Anna M, La Mendola, Diego, Giacomelli, Chiara, Trincavelli, Maria L, Tomasello, Marianna F, Milardi, Danilo, García-Viñuales, Sara, Sciacca, Michele F M, Martini, Claudia, Grasso, Giulia

“…Copper plays an important role as a regulator in many pathologies involving the angiogenesis process. In cancerogenesis, tumor progression, and angiogenic…”
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Electronic Circular Dichroism Detects Conformational Changes Associated with Proteasome Gating Confirmed Using AFM Imaging by D'Urso, Alessandro, Purrello, Roberto, Cunsolo, Alessandra, Milardi, Danilo, Fattorusso, Caterina, Persico, Marco, Gaczynska, Maria, Osmulski, Pawel A, Santoro, Anna Maria

“…Many chronic diseases, including cancer and neurodegeneration, are linked to proteasome dysregulation. Proteasome activity, essential for maintaining…”
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