12-Week aerobic exercise and nutritional program minimized the presence of the 64Arg allele on insulin resistance

12-Week aerobic exercise and nutritional program minimized the presence of the 64Arg allele on insulin resistance

The objective of the study was to investigate the response of 64Arg allele carriers of the ADRB3 gene (Trp64Arg polymorphism) in the anthropometric, cardiorespiratory and metabolic variables in overweight adolescents after a 12-week aerobic exercise and nutritional program. A total of 92 overweight...

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Bibliographic Details
Published in:Journal of pediatric endocrinology & metabolism : JPEM Vol. 31; no. 9; p. 1033
Main Authors: Milano-Gai, Gerusa E, Furtado-Alle, Lupe, Mota, Jorge, Lazarotto, Leilane, Milano, Gisele E, de Souza Lehtonen, Ricardo R, Titski, Ana C K, Jesus, Íncare C, Tureck, Luciane V, Radominski, Rosana B, Coelho-E-Silva, Manuel João, Leite, Neiva
Format: Journal Article
Language:English
Published: Germany 25-09-2018
Subjects:
Adolescent
Alleles
Body Composition
Child
Diet
Exercise - physiology
Female
Genotype
Health Behavior
Humans
Insulin Resistance - genetics
Male
Overweight - genetics
Overweight - therapy
Polymorphism, Single Nucleotide
Receptors, Adrenergic, beta-3 - genetics
Treatment Outcome
polymorphism
adolescents
overweight
Trp64Arg
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Summary:The objective of the study was to investigate the response of 64Arg allele carriers of the ADRB3 gene (Trp64Arg polymorphism) in the anthropometric, cardiorespiratory and metabolic variables in overweight adolescents after a 12-week aerobic exercise and nutritional program. A total of 92 overweight adolescents, 10-16 years old and of both genders, participated. Body composition, waist circumference (WC), pubertal stage status, blood pressure, glucose, insulin and lipid profile and direct maximal oxygen uptake were assessed at baseline and after 12 weeks of a training program. The homeostasis metabolic assessments [homeostasis model assessment of insulin resistance (HOMA-IR)] and quantitative insulin sensitivity check index (QUICKI) were determined and the Trp64Arg polymorphism of the ADRB3 gene was investigated by Taqman single nucleotide polymorphism (SNP) genotyping assays. Exercise sessions consisted of 100-min aerobic exercise and 20-min stretching, 3 times a week, totalizing 36 sessions. Multivariate analysis of variance (MANOVA), analysis of covariance (ANCOVA) and effect size were used for variables, with p<0.05 considered significant. In baseline, HOMA-IR was higher in carriers of the 64Arg allele and decreased more after 12 weeks than in non-carriers (p=0.01). The anthropometric, physical fitness and metabolic profiles had similar responses after training in carriers and non-carriers. Overweight adolescents present changes in body composition and physical fitness, independent of Trp64Arg genotypes. However, a 12-week aerobic exercise and nutritional program promoted greater reductions in insulin resistance in carriers of the 64Arg allele.
ISSN:2191-0251
DOI:10.1515/jpem-2018-0066