Search Results - "Milaneschi, Yuri"

Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts by Milaneschi, Yuri, Kappelmann, Nils, Ye, Zheng, Lamers, Femke, Moser, Sylvain, Jones, Peter B., Burgess, Stephen, Penninx, Brenda W. J. H., Khandaker, Golam M.

“…We examined whether inflammation is uniformly associated with all depressive and anxiety symptoms, and whether these associations are potentially causal. Data…”
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Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile by Penninx, Brenda W J H, Milaneschi, Yuri, Lamers, Femke, Vogelzangs, Nicole

“…Depression is the most common psychiatric disorder worldwide. The burden of disease for depression goes beyond functioning and quality of life and extends to…”
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Inflammation and depression in young people: a systematic review and proposed inflammatory pathways by Toenders, Yara J., Laskaris, Liliana, Davey, Christopher G., Berk, Michael, Milaneschi, Yuri, Lamers, Femke, Penninx, Brenda W. J. H., Schmaal, Lianne

“…Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel…”
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The trajectory of depressive symptoms across the adult life span by Sutin, Angelina R, Terracciano, Antonio, Milaneschi, Yuri, An, Yang, Ferrucci, Luigi, Zonderman, Alan B

“…Long-term longitudinal studies are needed to delineate the trajectory of depressive symptoms across adulthood and to individuate factors that may contribute to…”
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Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples by Aberg, Karolina A., Dean, Brian, Shabalin, Andrey A., Chan, Robin F., Han, Laura K. M., Zhao, Min, van Grootheest, Gerard, Xie, Lin Y., Milaneschi, Yuri, Clark, Shaunna L., Turecki, Gustavo, Penninx, Brenda W. J. H., van den Oord, Edwin J. C. G.

“…We present the first large-scale methylome-wide association studies (MWAS) for major depressive disorder (MDD) to identify sites of potential importance for…”
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An integrative study of five biological clocks in somatic and mental health by Jansen, Rick, Han, Laura Km, Verhoeven, Josine E, Aberg, Karolina A, van den Oord, Edwin Cgj, Milaneschi, Yuri, Penninx, Brenda Wjh

“…Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders…”
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Genetic variants associated with longitudinal changes in brain structure across the lifespan by Schnack, Hugo G., Jahanshad, Neda, Thomopoulos, Sophia I., Sprooten, Emma, Gogtay, Nitin, Whelan, Christopher D., Alloza, Clara, Artiges, Eric, Blok, Elisabet, Bright, Joanna K., Buimer, Elizabeth E. L., Cannon, Dara M., Ciufolini, Simone, Crossley, Nicolas A., Damatac, Christienne G., de Mol, Casper L., de Zwarte, Sonja M. C., Díaz-Caneja, Covadonga M., Doan, Nhat Trung, Dohm, Katharina, Fröhner, Juliane H., Goltermann, Janik, Grigis, Antoine, Han, Laura K. M., Hartman, Catharina A., Heindel, Walter, Janssen, Joost, Jiang, Jiyang, Jockwitz, Christiane, Lenroot, Rhoshel K., Mandl, René C. W., Medel, Vicente, de la Foz, Víctor Ortiz-García, Overs, Bronwyn J., Paillère Martinot, Marie-Laure, Repple, Jonathan, Roberts, Gloria, Setiaman, Nikita, Shumskaya, Elena, Wen, Wei, Westeneng, Henk-Jan, Wittfeld, Katharina, Zugman, Andre, Armstrong, Nicola J., Davies, Gail, Di Forti, Marta, Ding, Linda, Donohoe, Gary, Forstner, Andreas J., Guimaraes, Joao P. O. F. T., Knol, Maria J., Kwok, John B. J., Milaneschi, Yuri, Morris, Derek W., Rietschel, Marcella, Streit, Fabian, van ‘t Ent, Dennis, van der Meer, Dennis, van Eijk, Kristel R., Vázquez-Bourgon, Javier, Witt, Stephanie H., Agartz, Ingrid, Ames, David, Amunts, Katrin, Arango, Celso, Baune, Bernhard T., Belangero, Sintia I., Bokde, Arun L. W., Boomsma, Dorret I., Bressan, Rodrigo A., Brodaty, Henry, Cahn, Wiepke, Caspers, Svenja, Cox, Simon R., Fisher, Simon E., Flor, Herta, Grabe, Hans J., Hoekstra, Pieter J., Jackowski, Andrea P., Jansen, Andreas, Jönsson, Erik G., Kahn, Rene S., Kircher, Tilo, Krug, Axel, Lemaitre, Herve, Martinot, Jean-Luc, McDonald, Colm, Nenadić, Igor, Pan, Pedro M., Penninx, Brenda W. J. H., Poustka, Luise, Schofield, Peter R., Schumann, Gunter, Sim, Kang, Trollor, Julian N., Veldink, Jan H., Westlye, Lars T., Whelan, Robert, Medland, Sarah E., Thompson, Paul M.

“…Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental…”
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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank by Coleman, Jonathan R. I., Peyrot, Wouter J., Purves, Kirstin L., Davis, Katrina A. S., Rayner, Christopher, Choi, Shing Wan, Hübel, Christopher, Gaspar, Héléna A., Kan, Carol, Van der Auwera, Sandra, Adams, Mark James, Lyall, Donald M., Choi, Karmel W., Dunn, Erin C., Vassos, Evangelos, Danese, Andrea, Maughan, Barbara, Grabe, Hans J., Lewis, Cathryn M., O’Reilly, Paul F., McIntosh, Andrew M., Smith, Daniel J., Wray, Naomi R., Hotopf, Matthew, Eley, Thalia C., Breen, Gerome

“…Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between…”
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A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank by Shen, Xueyi, Howard, David M., Adams, Mark J., Hill, W. David, Clarke, Toni-Kim, Deary, Ian J., Whalley, Heather C., McIntosh, Andrew M.

“…Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using…”
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Effect of polygenic risk scores on depression in childhood trauma by Peyrot, Wouter J., Milaneschi, Yuri, Abdellaoui, Abdel, Sullivan, Patrick F., Hottenga, Jouke J., Boomsma, Dorret I., Penninx, Brenda W. J. H.

“…Research on gene × environment interaction in major depressive disorder (MDD) has thus far primarily focused on candidate genes, although genetic effects are…”
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Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression by Forstner, Andreas J., Awasthi, Swapnil, Wolf, Christiane, Maron, Eduard, Erhardt, Angelika, Czamara, Darina, Eriksson, Elias, Lavebratt, Catharina, Allgulander, Christer, Friedrich, Nina, Becker, Jessica, Hecker, Julian, Rambau, Stefanie, Conrad, Rupert, Geiser, Franziska, McMahon, Francis J., Moebus, Susanne, Hess, Timo, Buerfent, Benedikt C., Hoffmann, Per, Herms, Stefan, Heilmann-Heimbach, Stefanie, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars, Weber, Heike, Alpers, Georg W., Arolt, Volker, Fehm, Lydia, Fydrich, Thomas, Gerlach, Alexander L., Hamm, Alfons, Kircher, Tilo, Pané-Farré, Christiane A., Pauli, Paul, Rief, Winfried, Ströhle, Andreas, Plag, Jens, Lang, Thomas, Wittchen, Hans-Ulrich, Mattheisen, Manuel, Meier, Sandra, Metspalu, Andres, Domschke, Katharina, Reif, Andreas, Hovatta, Iiris, Lindefors, Nils, Andersson, Evelyn, Schalling, Martin, Mbarek, Hamdi, Milaneschi, Yuri, de Geus, Eco J. C., Boomsma, Dorret I., Penninx, Brenda W. J. H., Thorgeirsson, Thorgeir E., Steinberg, Stacy, Stefansson, Kari, Stefansson, Hreinn, Müller-Myhsok, Bertram, Hansen, Thomas Folkmann, Børglum, Anders D., Werge, Thomas, Mortensen, Preben Bo, Nordentoft, Merete, Hougaard, David M., Hultman, Christina M., Sullivan, Patrick F., Nöthen, Markus M., Woldbye, David P. D., Mors, Ole, Binder, Elisabeth B., Rück, Christian, Ripke, Stephan, Deckert, Jürgen, Schumacher, Johannes

“…Panic disorder (PD) has a lifetime prevalence of 2–4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and…”
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Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium by Power, Robert A, Tansey, Katherine E, Buttenschøn, Henriette Nørmølle, Cohen-Woods, Sarah, Bigdeli, Tim, Hall, Lynsey S, Kutalik, Zoltán, Lee, S. Hong, Ripke, Stephan, Steinberg, Stacy, Teumer, Alexander, Viktorin, Alexander, Wray, Naomi R, Arolt, Volker, Baune, Bernard T, Boomsma, Dorret I, Børglum, Anders D, Byrne, Enda M, Castelao, Enrique, Craddock, Nick, Craig, Ian W, Dannlowski, Udo, Deary, Ian J, Degenhardt, Franziska, Forstner, Andreas J, Gordon, Scott D, Grabe, Hans J, Grove, Jakob, Hamilton, Steven P, Hayward, Caroline, Heath, Andrew C, Hocking, Lynne J, Homuth, Georg, Hottenga, Jouke J, Kloiber, Stefan, Krogh, Jesper, Landén, Mikael, Lang, Maren, Levinson, Douglas F, Lichtenstein, Paul, Lucae, Susanne, MacIntyre, Donald J, Madden, Pamela, Magnusson, Patrik K.E, Martin, Nicholas G, McIntosh, Andrew M, Middeldorp, Christel M, Milaneschi, Yuri, Montgomery, Grant W, Mors, Ole, Müller-Myhsok, Bertram, Nyholt, Dale R, Oskarsson, Hogni, Owen, Michael J, Padmanabhan, Sandosh, Penninx, Brenda W.J.H, Pergadia, Michele L, Porteous, David J, Potash, James B, Preisig, Martin, Rivera, Margarita, Shi, Jianxin, Shyn, Stanley I, Sigurdsson, Engilbert, Smit, Johannes H, Smith, Blair H, Stefansson, Hreinn, Stefansson, Kari, Strohmaier, Jana, Sullivan, Patrick F, Thomson, Pippa, Thorgeirsson, Thorgeir E, Van der Auwera, Sandra, Weissman, Myrna M, Breen, Gerome, Lewis, Cathryn M

“…Abstract Background Major depressive disorder (MDD) is a disabling mood disorder, and despite a known heritable component, a large meta-analysis of genome-wide…”
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Metabolomic and inflammatory signatures of symptom dimensions in major depression by Brydges, Christopher R., Bhattacharyya, Sudeepa, Dehkordi, Siamak Mahmoudian, Milaneschi, Yuri, Penninx, Brenda, Jansen, Rick, Kristal, Bruce S., Han, Xianlin, Arnold, Matthias, Kastenmüller, Gabi, Bekhbat, Mandakh, Mayberg, Helen S, Craighead, W. Edward, Rush, A John, Fiehn, Oliver, Dunlop, Boadie W, Kaddurah-Daouk, Rima

“…•Major depressive disorder (MDD) can be theorized as a series of symptom dimensions.•We examined metabolic associations of three MDD symptom…”
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Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns by Czamara, Darina, Eraslan, Gökçen, Page, Christian M., Lahti, Jari, Lahti-Pulkkinen, Marius, Hämäläinen, Esa, Kajantie, Eero, Laivuori, Hannele, Villa, Pia M., Reynolds, Rebecca M., Nystad, Wenche, Håberg, Siri E., London, Stephanie J., O’Donnell, Kieran J., Garg, Elika, Meaney, Michael J., Entringer, Sonja, Wadhwa, Pathik D., Buss, Claudia, Jones, Meaghan J., Lin, David T. S., MacIsaac, Julie L., Kobor, Michael S., Koen, Nastassja, Zar, Heather J., Koenen, Karestan C., Dalvie, Shareefa, Stein, Dan J., Kondofersky, Ivan, Müller, Nikola S., Theis, Fabian J., Räikkönen, Katri, Binder, Elisabeth B.

“…Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular…”
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Reconsidering the prognosis of major depressive disorder across diagnostic boundaries: full recovery is the exception rather than the rule by Verduijn, Judith, Verhoeven, Josine E, Milaneschi, Yuri, Schoevers, Robert A, van Hemert, Albert M, Beekman, Aartjan T F, Penninx, Brenda W J H

“…Major depressive disorder (MDD) is often handled as an episodic and isolated disorder, resulting in an optimistic view about its prognosis. Herein, we test the…”
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Physical Activity as Moderator of the Association Between APOE and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies by Stringa, Najada, van Schoor, Natasja M, Milaneschi, Yuri, Ikram, M Arfan, Del Panta, Vieri, Koolhaas, Chantal M, Voortman, Trudy, Bandinelli, Stefania, Wolters, Frank J, Huisman, Martijn

“…Abstract Background Previous studies have suggested that the association between APOE ɛ 4 and dementia is moderated by physical activity (PA), but the results…”
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Baseline biopsychosocial determinants of telomere length and 6-year attrition rate by Révész, Dóra, Milaneschi, Yuri, Terpstra, Erik M, Penninx, Brenda W.J.H

“…Highlights • No large study has systematically explored predictors of telomere length and telomere attrition. • Sociodemographic, lifestyle, and psychosocial,…”
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Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts by Pistis, Giorgio, Milaneschi, Yuri, Vandeleur, Caroline L., Lasserre, Aurélie M., Penninx, Brenda W.J.H., Lamers, Femke, Boomsma, Dorret I., Hottenga, Jouke-Jan, Marques-Vidal, Pedro, Vollenweider, Peter, Waeber, Gérard, Aubry, Jean-Michel, Preisig, Martin, Kutalik, Zoltán

“…Studies considering the causal role of body mass index (BMI) for the predisposition of major depressive disorder (MDD) based on a Mendelian Randomization (MR)…”
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A methylation study of long-term depression risk by Clark, Shaunna L., Hattab, Mohammad W., Chan, Robin F., Shabalin, Andrey A., Han, Laura K. M., Zhao, Min, Smit, Johannes H., Jansen, Rick, Milaneschi, Yuri, Xie, Lin Ying, van Grootheest, Gerard, Penninx, Brenda W. J. H., Aberg, Karolina A., van den Oord, Edwin J. C. G.

“…Recurrent and chronic major depressive disorder (MDD) accounts for a substantial part of the disease burden because this course is most prevalent and typically…”
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Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia by Sønderby, Ida E, Doan, Nhat Trung, Hibar, Derrek P, Martin-Brevet, Sandra, Abdellaoui, Abdel, Ames, David, Amunts, Katrin, Armstrong, Nicola J, Blangero, John, Boomsma, Dorret I, Brattbak, Hans-Richard, Brodaty, Henry, Brouwer, Rachel M, Calhoun, Vince, Caspers, Svenja, Corvin, Aiden, Crespo-Facorro, Benedicto, Dazzan, Paola, de Geus, Eco J C, Delanty, Norman, Desrivières, Sylvane, Draganski, Bogdan, Ehrlich, Stefan, Fisher, Simon E, Franke, Barbara, Frouin, Vincent, Fukunaga, Masaki, Gareau, Thomas, Groenewold, Nynke A., Hashimoto, Ryota, Hehir-Kwa, Jayne Y, Heinz, Andreas, Hillegers, Manon H. J., Holleran, Laurena, Hottenga, Jouke-Jan, Hulshoff, Hilleke E, Jernigan, Terry, Jockwitz, Christiane, Jonsdottir, Gudrun A, Jönsson, Erik G, Kahn, Rene, Kelly, Sinead, Kolskår, Knut K, Kwok, John B, Hellard, Stephanie Le, Leu, Costin, Lundervold, Astri J, Lundervold, Arvid, Martin, Nicholas G., Mather, Karen, Mathias, Samuel R., McCormack, Mark, McMahon, Katie L., McRae, Allan, Milaneschi, Yuri, Moreau, Clara, Morris, Derek, Mothersill, David, Murray, Robin, Nordvik, Jan E, Nyberg, Lars, Olde Loohuis, Loes M, Pausova, Zdenka, Penninx, Brenda, Prieto, Carlos, Pudas, Sara, Quinlan, Erin, Marques, Tiago Reis, Reymond, Alexandre, Richard, Genevieve, Rodriguez-Herreros, Borja, Roiz-Santiañez, Roberto, Rokicki, Jarek, Sachdev, Perminder, Schmaal, Lianne, Schofield, Peter R, Schumann, Gunter, Steen, Vidar M, Stein, Dan J, Strike, Lachlan, Teumer, Alexander, Thalamuthu, Anbu, Turner, Jessica, Ulfarsson, Magnus O., van ’t Ent, Dennis, van der Meer, Dennis, Vassos, Evangelos, Walters, G. Bragi, Wang, Yunpeng, Wen, Wei, Whelan, Christopher D, Wittfeld, Katharina, Wright, Margie, Yamamori, Hidenaga, Agartz, Ingrid, Westlye, Lars T, Jacquemont, Sébastien, Djurovic, Srdjan, Thompson, Paul, Andreassen, Ole A.

“…Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes…”
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