Search Results - "Miláčková, Ivana"
-
1
Artichoke Leaf Extract Inhibits AKR1B1 and Reduces NF‐κB Activity in Human Leukemic Cells
Published in Phytotherapy research (01-03-2017)“…The human intracellular enzyme AKR1B1 belongs to the aldo‐keto reductase superfamily. The AKR1B1‐catalyzed reduction of aldehydes is part of the intracellular…”
Get full text
Journal Article -
2
Genistein Improves Skin Flap Viability in Rats: A Preliminary In Vivo and In Vitro Investigation
Published in Molecules (Basel, Switzerland) (04-07-2018)“…Selective estrogen receptor modulators (SERMs) have been developed to achieve beneficial effects of estrogens while minimizing their side effects. In this…”
Get full text
Journal Article -
3
Water leaves extracts of Cornus mas and Cornus kousa as aldose reductase inhibitors: the potential therapeutic agents
Published in Chemical papers (01-12-2017)“…The Cornaceae family is mainly known for the research connected with its fruits and flowers, but the biological activities of leaves of Cornus species are not…”
Get full text
Journal Article -
4
Artichoke Leaf Extract Inhibits AKR1B1 and Reduces NF-κB Activity in Human Leukemic Cells: ARTICHOKE LEAF EXTRACT INHIBITS AKR1B1 AND NF-ΚB
Published in Phytotherapy research (01-03-2017)Get full text
Journal Article -
5
Indole- and Chromane-type heterocycles: Playing with molecules to defeat ageing
Published in Free radical biology & medicine (01-09-2015)Get full text
Journal Article -
6
PP39 - Indole- and Chromane-type heterocycles: Playing with molecules to defeat ageing
Published in Free radical biology & medicine (01-09-2015)“…Heterocyclic compounds with chromane- and indole-type skeleton represent two fairly large groups of substances with proved beneficial antioxidant effects even…”
Get full text
Journal Article -
7
Artichoke Leaf Extract Inhibits AKR1B1 and Reduces NF-[kappa]B Activity in Human Leukemic Cells
Published in Phytotherapy research (01-03-2017)“…The human intracellular enzyme AKR1B1 belongs to the aldo-keto reductase superfamily. The AKR1B1-catalyzed reduction of aldehydes is part of the intracellular…”
Get full text
Journal Article -
8
2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent
Published in Journal of enzyme inhibition and medicinal chemistry (01-02-2015)“…The ability of flavonoids to affect multiple key pathways of glucose toxicity, as well as to attenuate inflammation has been well documented. In this study,…”
Get more information
Journal Article -
9
Antioxidant action of the hexahydropyridoindole SMe1EC2 in the cellular system of isolated red blood cells in vitro
Published in Redox report : communications in free radical research (01-03-2013)“…Objectives The subject of this study was the hexahydropyridoindole compound SMe1EC2 with reported antioxidant and neuroprotective effects and low toxicity. In…”
Get full text
Journal Article -
10
Molecular Interactions and Implications of Aldose Reductase Inhibition by PGA1 and Clinically Used Prostaglandins
Published in Molecular pharmacology (01-01-2016)“…Aldose reductase (AKR1B1) is a critical drug target because of its involvement in diabetic complications, inflammation, and tumorigenesis. However, to date,…”
Get more information
Journal Article -
11
Substituted hexahydropyridoindoles—Effective scavengers of free radicals
Published in Toxicology letters (17-06-2012)Get full text
Journal Article -
12
(2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: An aldose reductase inhibitor and antioxidant of zwitterionic nature
Published in Bioorganic & medicinal chemistry (01-12-2011)“…Chemical structure of (2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid (1) and stobadine…”
Get full text
Journal Article -
13
Protection or cytotoxicity mediated by a novel quinonoid-polyphenol compound?
Published in General physiology and biophysics (01-01-2015)“…Many natural and synthetic quinones and naphthoquinones possess a variety of beneficial pharmacological properties. In plants, the cytotoxic properties of…”
Get more information
Journal Article -
14
Screening for antiradical efficiency of 21 semi-synthetic derivatives of quercetin in a DPPH assay
Published in Interdisciplinary toxicology (01-03-2013)“…The group of 21 novel semi-synthetic derivatives of quercetin was screened for the antiradical efficiency in a DPPH assay. The initial fast absorbance decrease…”
Get full text
Journal Article -
15
-
16
-
17
[5-(Benzyloxy)-1H-indol-1-yl]acetic acid, an aldose reductase inhibitor and PPARγ ligand
Published in Acta biochimica Polonica (2015)“…Based on overlapping structural requirements for both efficient aldose reductase inhibitors and PPAR ligands, [5-(benzyloxy)-1H-indol-1-yl]acetic acid…”
Get full text
Journal Article -
18
Aldose reductase inhibitory activity and antioxidant capacity of pomegranate extracts
Published in Interdisciplinary toxicology (01-03-2012)“…The pomegranate, Punica granatum L., has been the subject of current interest as a medicinal agent with wide-ranging therapeutic indications. In the present…”
Get full text
Journal Article