The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder

INTRODUCTION Emotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients’ descriptions of their cognitive symptoms. METHODS We compared cognitive status and structural and f...

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Published in:	Alzheimer's & dementia : translational research & clinical interventions Vol. 10; no. 1; pp. e12450 - n/a
Main Authors:	Yulug, Burak, Ayyildiz, Sevilay, Sayman, Dila, Karaca, Ramazan, Ipek, Lutfiye, Cankaya, Seyda, Salar, Ali Behram, Ayyildiz, Behcet, Mikuta, Christian, Yagci, Nilay, Oktem, Ece Ozdemir, Ozsimsek, Ahmet, Velioglu, Halil Aziz, Hanoglu, Lutfu
Format:	Journal Article
Language:	English
Published:	United States John Wiley and Sons Inc 01-01-2024 Wiley
Subjects:	amnestic depression cognition depression functional magnetic resonance imaging pulvinar amnestic depression depression cognition pulvinar functional magnetic resonance imaging
Online Access:	Get full text
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Summary:	INTRODUCTION Emotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients’ descriptions of their cognitive symptoms. METHODS We compared cognitive status and structural and functional brain connectivity changes in the pulvinar and hippocampus between patients with total depression and healthy controls. The depressive group was also classified as “amnestic” or “nonamnestic,” based on the members’ subjective reports concerning their forgetfulness. We then sought to determine whether these patients would differ in terms of objective neuroimaging and cognitive findings. RESULTS The right pulvinar exhibited altered connectivity in individuals with depression with objective cognitive impairment, a finding which was not apparent in depressive patients with subjective cognitive impairment. DISCUSSION The pulvinar may play a role in depression‐related cognitive impairments. Connectivity network changes may differ between objective and subjective cognitive impairment in depression and may play a role in the increased risk of dementia in patients with depression.
Bibliography:	Burak Yulug, Sevilay Ayyildiz, and Halil Aziz Velioglu contributed equally to this study and share senior authorship. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2352-8737 2352-8737
DOI:	10.1002/trc2.12450