Search Results - "Mikusova, Katarina"

DprE1--from the discovery to the promising tuberculosis drug target by Mikusová, Katarína, Makarov, Vadim, Neres, João

“…Several groups working in the field of the development of new antituberculosis drugs have recently reported active compounds targeting mycobacterial enzyme…”
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Galactosyl Transferases in Mycobacterial Cell Wall Synthesis by BELANOVA, Martina, DIANISKOVA, Petronela, BRENNAN, Patrick J, COMPLETO, Gladys C, ROSE, Natisha L, LOWARY, Todd L, MIKULOVH, Katarina

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Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors by Sabbah, Mohamad, Mendes, Vitor, Vistal, Robert G, Dias, David M. G, Záhorszká, Monika, Mikušová, Katarína, Korduláková, Jana, Coyne, Anthony G, Blundell, Tom L, Abell, Chris

“…Tuberculosis (TB) remains a leading cause of mortality among infectious diseases worldwide. InhA has been the focus of numerous drug discovery efforts as this…”
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Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase DprE1 by Trefzer, Claudia, Škovierová, Henrieta, Buroni, Silvia, Bobovská, Adela, Nenci, Simone, Molteni, Elisabetta, Pojer, Florence, Pasca, Maria R, Makarov, Vadim, Cole, Stewart T, Riccardi, Giovanna, Mikušová, Katarína, Johnsson, Kai

“…Benzothiazinones (BTZs) are antituberculosis drug candidates with nanomolar bactericidal activity against tubercle bacilli. Here we demonstrate that BTZs are…”
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Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis by Karabanovich, Galina, Zemanová, Júlia, Smutný, Tomáš, Székely, Rita, Šarkan, Michal, Centárová, Ivana, Vocat, Anthony, Pávková, Ivona, Čonka, Patrik, Němeček, Jan, Stolaříková, Jiřina, Vejsová, Marcela, Vávrová, Kateřina, Klimešová, Věra, Hrabálek, Alexandr, Pávek, Petr, Cole, Stewart T, Mikušová, Katarína, Roh, Jaroslav

“…Herein, we report the discovery and structure–activity relationships of 5-substituted-2-[(3,5-dinitrobenzyl)­sulfanyl]-1,3,4-oxadiazoles and 1,3,4-thiadiazoles…”
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DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization by Brecik, Miroslav, Centárová, Ivana, Mukherjee, Raju, Kolly, Gaëlle S, Huszár, Stanislav, Bobovská, Adela, Kilacsková, Emöke, Mokošová, Veronika, Svetlíková, Zuzana, Šarkan, Michal, Neres, João, Korduláková, Jana, Cole, Stewart T, Mikušová, Katarína

“…The flavo-enzyme DprE1 catalyzes a key epimerization step in the decaprenyl-phosphoryl d-arabinose (DPA) pathway, which is essential for mycobacterial cell…”
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Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents by Hajian, Behnoush, Scocchera, Eric, Shoen, Carolyn, Krucinska, Jolanta, Viswanathan, Kishore, G-Dayanandan, Narendran, Erlandsen, Heidi, Estrada, Alexavier, Mikušová, Katarína, Korduláková, Jana, Cynamon, Michael, Wright, Dennis

“…The folate biosynthetic pathway offers many druggable targets that have yet to be exploited in tuberculosis therapy. Herein, we have identified a series of…”
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Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β‑d‑ribofuranose 2′-Oxidase by Karabanovich, Galina, Dušek, Jan, Savková, Karin, Pavliš, Oto, Pávková, Ivona, Korábečný, Jan, Kučera, Tomáš, Kočová Vlčková, Hana, Huszár, Stanislav, Konyariková, Zuzana, Konečná, Klára, Jand’ourek, Ondřej, Stolaříková, Jiřina, Korduláková, Jana, Vávrová, Kateřina, Pávek, Petr, Klimešová, Věra, Hrabálek, Alexandr, Mikušová, Katarína, Roh, Jaroslav

“…We report herein the discovery of 3,5-dinitrophenyl 1,2,4-triazoles with excellent and selective antimycobacterial activities against Mycobacterium…”
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Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents by Fan, Dongguang, Wang, Bin, Stelitano, Giovanni, Savková, Karin, Shi, Rui, Huszár, Stanislav, Han, Quanquan, Mikušová, Katarína, Chiarelli, Laurent R, Lu, Yu, Qiao, Chunhua

“…The benzothiazinone (BTZ) scaffold compound PBTZ169 kills by inhibiting the essential flavoenzyme DprE1, consequently blocking the synthesis of the cell wall…”
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Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway by Karabanovich, Galina, Fabiánová, Viktória, Vocat, Anthony, Dušek, Jan, Valášková, Lenka, Stolaříková, Jiřina, Kitson, Russell R. A., Pávek, Petr, Vávrová, Kateřina, Djaout, Kamel, Mikušová, Katarína, Baulard, Alain R., Cole, Stewart T., Korduláková, Jana, Roh, Jaroslav

“…3,5-Dinitrobenzylsulfanyl tetrazoles and 1,3,4-oxadiazoles, previously identified as having high in vitro activities against both replicating and…”
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Decaprenylphosphoryl Arabinofuranose, the Donor of the d-Arabinofuranosyl Residues of Mycobacterial Arabinan, Is Formed via a Two-Step Epimerization of Decaprenylphosphoryl Ribose by MIKUSOVA, Katarina, HAIRONG HUANG, YAGI, Tetsuya, HOLSTERS, Marcelle, VEREECKE, Danny, D'HAEZE, Wim, SCHERMAN, Michael S, BRENNAN, Patrick J, MCNEIL, Michael R, CRICK, Dean C

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Compartmentalization of galactan biosynthesis in mycobacteria by Savková, Karin, Danchenko, Maksym, Fabianová, Viktória, Bellová, Jana, Bencúrová, Mária, Huszár, Stanislav, Korduláková, Jana, Siváková, Barbara, Baráth, Peter, Mikušová, Katarína

“…Galactan polymer is a prominent component of the mycobacterial cell wall core. Its biogenesis starts at the cytoplasmic side of the plasma membrane by a…”
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Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents by Liu, Lingfeng, Kong, Chengcheng, Fumagalli, Marco, Savková, Karin, Xu, Yiwen, Huszár, Stanislav, Sammartino, José C., Fan, Dongguang, Chiarelli, Laurent R., Mikušová, Katarína, Sun, Zhaogang, Qiao, Chunhua

“…Decaprenylphosphoryl-β-d-ribose 2′-oxidoreductase (DprE1) is a promising drug target for the development of novel anti-tubercular agents, and inhibitors of…”
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Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA by Albesa-Jové, David, Svetlíková, Zuzana, Tersa, Montse, Sancho-Vaello, Enea, Carreras-González, Ana, Bonnet, Pascal, Arrasate, Pedro, Eguskiza, Ander, Angala, Shiva K., Cifuente, Javier O., Korduláková, Jana, Jackson, Mary, Mikušová, Katarína, Guerin, Marcelo E.

“…The biosynthesis of phospholipids and glycolipids are critical pathways for virtually all cell membranes. PatA is an essential membrane associated…”
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Identification of a small molecule with activity against drug-resistant and persistent tuberculosis by Wang, Feng, Sambandan, Dhinakaran, Halder, Rajkumar, Wang, Jianing, Batt, Sarah M, Weinrick, Brian, Ahmad, Insha, Yang, Pengyu, Zhang, Yong, Kim, John, Hassani, Morad, Huszar, Stanislav, Trefzer, Claudia, Ma, Zhenkun, Kaneko, Takushi, Mdluli, Khisi E, Franzblau, Scott, Chatterjee, Arnab K, Johnsson, Kai, Johnson, Kai, Mikusova, Katarina, Besra, Gurdyal S, Fütterer, Klaus, Robbins, Scott H, Barnes, S Whitney, Walker, John R, Jacobs, Jr, William R, Schultz, Peter G

“…A cell-based phenotypic screen for inhibitors of biofilm formation in mycobacteria identified the small molecule TCA1, which has bactericidal activity against…”
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Synthesis, docking study and biological evaluation of ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones as potential inhibitors of the mycobacterial galactan synthesis targeting the galactofuranosyltransferase GlfT2 by Baráth, Marek, Jakubčinová, Jana, Konyariková, Zuzana, Kozmon, Stanislav, Mikušová, Katarína, Bella, Maroš

“…A series of ten novel ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones bearing a 1- -phosphono moiety and three different substituents at C-2 has been…”
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Copper-related toxicity in replicating and dormant Mycobacterium tuberculosis caused by 1-hydroxy-5-R-pyridine-2(1H)-thiones by Salina, Elena G, Huszár, Stanislav, Zemanová, Júlia, Keruchenko, Jan, Riabova, Olga, Kazakova, Elena, Grigorov, Artyom, Azhikina, Tatyana, Kaprelyants, Arseny, Mikušová, Katarína, Makarov, Vadim

“…With the emerging primary resistance of Mycobacterium tuberculosis to current drugs and wide distribution of latent tuberculosis infection, the need for new…”
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Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043 by Tiwari, Rohit, Miller, Patricia A, Chiarelli, Laurent R, Mori, Giorgia, Šarkan, Michal, Centárová, Ivana, Cho, Sanghyun, Mikušová, Katarína, Franzblau, Scott G, Oliver, Allen G, Miller, Marvin J

“…Electron deficient nitroaromatic compounds such as BTZ043 and its closest congener, PBTZ169, and related agents are a promising new class of anti-TB compounds…”
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The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis by Makarov, Vadim, Neres, João, Hartkoorn, Ruben C, Ryabova, Olga B, Kazakova, Elena, Šarkan, Michal, Huszár, Stanislav, Piton, Jérémie, Kolly, Gaëlle S, Vocat, Anthony, Conroy, Trent M, Mikušová, Katarína, Cole, Stewart T

“…8-Nitro-benzothiazinones (BTZs), such as BTZ043 and PBTZ169, inhibit decaprenylphosphoryl-β-d-ribose 2'-oxidase (DprE1) and display nanomolar bactericidal…”
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GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosis by Kolly, Gaëlle S, Mukherjee, Raju, Kilacsková, Emöke, Abriata, Luciano A, Raccaud, Mahé, Blaško, Jaroslav, Sala, Claudia, Dal Peraro, Matteo, Mikušová, Katarína, Cole, Stewart T

“…Mycobacterium tuberculosis possesses a thick and highly hydrophobic cell wall principally composed of a mycolyl-arabinogalactan-peptidoglycan complex, which is…”
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