Search Results - "Mikulits, W"

The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma by Govaere, O, Petz, M, Wouters, J, Vandewynckel, Y-P, Scott, E J, Topal, B, Nevens, F, Verslype, C, Anstee, Q M, Van Vlierberghe, H, Mikulits, W, Roskams, T

“…Human hepatocellular carcinomas (HCCs) expressing the biliary/hepatic progenitor cell marker keratin 19 (K19) have been linked with a poor prognosis and…”
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The transcription factor ZEB1 ( EF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity by AIGNER, K, DAMPIER, B, SOMMERGRUBER, W, SCHWEIFER, N, WERNITZNIG, A, BEUG, H, FOISNER, R, EGER, A, DESCOVICH, L, MIKULA, M, SULTAN, A, SCHREIBER, M, MIKULITS, W, BRABLETZ, T, STRAND, D, OBRIST, P

“…Epithelial to mesenchymal transition (EMT) is implicated in the progression of primary tumours towards metastasis and is likely caused by a pathological…”
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ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression by Lahsnig, C, Mikula, M, Petz, M, Zulehner, G, Schneller, D, van Zijl, F, Huber, H, Csiszar, A, Beug, H, Mikulits, W

“…In human hepatocellular carcinoma (HCC), epithelial to mesenchymal transition (EMT) correlates with aggressiveness of tumors and poor survival. We employed a…”
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Identification of invasion-addicted genes driven by transforming growth factor-beta in hepatocellular carcinoma by Haider, C, Coulouarn, C, Grubinger, M, Schlangen, K, Mikulits, W

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PDGF essentially links TGF-β signaling to nuclear β-catenin accumulation in hepatocellular carcinoma progression by FISCHER, A. N. M, FUCHS, E, MIKULA, M, HUBER, H, BEUG, H, MIKULITS, W

“…The cooperation of Ras - extracellular signal-regulated kinase/mitogen-activated protein kinase and transforming growth factor (TGF)-beta signaling provokes an…”
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P0300 : Dichotomy of transforming growth factor-β signaling in hepatocellular carcinoma progression by Haider, C, Grubinger, M, Mikulits, W

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A crucial function of PDGF in TGF-β-mediated cancer progression of hepatocytes by GOTZMANN, J, FISCHER, A. N. M, MIKULITS, W, ZOJER, M, MIKULA, M, PROELL, V, HUBER, H, JECHLINGER, M, WAERNER, T, WEITH, A, BEUG, H

“…Polarized hepatocytes expressing hyperactive Ha-Ras adopt an invasive and metastatic phenotype in cooperation with transforming growth factor (TGF)-beta. This…”
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Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF-β dependent fashion by Mikula, M., Proell, V., Fischer, A.N.M., Mikulits, W.

“…The development of hepatocellular carcinomas from malignant hepatocytes is frequently associated with intra‐ and peritumoral accumulation of connective tissue…”
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Bay11-7082 inhibits the disintegration of the lymphendothelial barrier triggered by MCF-7 breast cancer spheroids; the role of ICAM-1 and adhesion by Viola, K, Kopf, S, Huttary, N, Vonach, C, Kretschy, N, Teichmann, M, Giessrigl, B, Raab, I, Stary, S, Krieger, S, Keller, T, Bauer, S, Hantusch, B, Szekeres, T, de Martin, R, Jäger, W, Mikulits, W, Dolznig, H, Krupitza, G, Grusch, M

“…Background: Many cancers spread through lymphatic routes, and mechanistic insights of tumour intravasation into the lymphatic vasculature and targets for…”
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P0259 : Transendothelial migration depends on transforming growth factor beta in hepatocellular carcinoma progression by Koudelkova, P, Weber, G, Dooley, S, Costina, V, Findeisen, P, Mikulits, W

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NF-κB mediates the 12(S)-HETE-induced endothelial to mesenchymal transition of lymphendothelial cells during the intravasation of breast carcinoma cells by Vonach, C, Viola, K, Giessrigl, B, Huttary, N, Raab, I, Kalt, R, Krieger, S, Vo, T P N, Madlener, S, Bauer, S, Marian, B, Hämmerle, M, Kretschy, N, Teichmann, M, Hantusch, B, Stary, S, Unger, C, Seelinger, M, Eger, A, Mader, R, Jäger, W, Schmidt, W, Grusch, M, Dolznig, H, Mikulits, W, Krupitza, G

“…Background: The intravasation of breast cancer into the lymphendothelium is an early step of metastasis. Little is known about the mechanisms of bulky cancer…”
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Transforming Growth Factor-Beta Triggers Transendothelial Migration during Hepatocellular Carcinoma Progression by Koudelkova, P, Weber, G, Costina, V, Dooley, S, Agarwal, R, Winter, P, Findeisen, P, Mikulits, W

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The crosstalk of RAS with the TGF-β family during carcinoma progression and its implications for targeted cancer therapy by Grusch, Michael, Petz, Michaela, Metzner, Thomas, Oztürk, Deniz, Schneller, Doris, Mikulits, Wolfgang

“…Both RAS and transforming growth factor (TGF)-β signaling cascades are central in tumorigenesis and show synergisms depending on tumor stage and tissue…”
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Crosstalk between TGF-B-Induced Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma by Malfettone, A, Soukupova, J, Fernando, J, Koudelkova, P, Bertran, E, Fabra, A, Grubinger, M, Rani, B, Giannelli, G, Mikulits, W, Fabregat, I

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Soluble Axl identifies patients at higher risk for hepatocellular carcinoma development: results from a large scale multicenter analysis by Dengler, M, Staufer, K, Huber, H, Stauber, R, Bantel, H, Weiss, K.H, Starlinger, P, Pock, H, Klöters-Plachky, P, Gotthardt, D.N, Rauch, P, Lackner, C, Stift, J, Brostjan, C, Gruenberger, T, Kumada, T, Toyoda, H, Tada, T, Weiss, T.S, Trauner, M, Mikulits, W

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Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge by van Zijl, F, Mair, M, Csiszar, A, Schneller, D, Zulehner, G, Huber, H, Eferl, R, Beug, H, Dolznig, H, Mikulits, W

“…The tumor–stroma crosstalk is a dynamic process fundamental in tumor development. In hepatocellular carcinoma (HCC), the progression of malignant hepatocytes…”
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Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of lymphendothelial gap formation in vitro by Madlener, S, Saiko, P, Vonach, C, Viola, K, Huttary, N, Stark, N, Popescu, R, Gridling, M, Vo, N T-P, Herbacek, I, Davidovits, A, Giessrigl, B, Venkateswarlu, S, Geleff, S, Jäger, W, Grusch, M, Kerjaschki, D, Mikulits, W, Golakoti, T, Fritzer-Szekeres, M, Szekeres, T, Krupitza, G

“…Background: Digalloyl-resveratrol (di-GA) is a synthetic compound aimed to combine the biological effects of the plant polyhydroxy phenols gallic acid and…”
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In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen by Kretschy, N, Teichmann, M, Kopf, S, Atanasov, A G, Saiko, P, Vonach, C, Viola, K, Giessrigl, B, Huttary, N, Raab, I, Krieger, S, Jäger, W, Szekeres, T, Nijman, S M, Mikulits, W, Dirsch, V M, Dolznig, H, Grusch, M, Krupitza, G

“…Background: As metastasis is the prime cause of death from malignancies, there is vibrant interest to discover options for the management of the different…”
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P47 AXL SIGNALING VIA 14-3-3 ZETA IS CENTRAL FOR THE PROGRESSION OF HEPATOCELLULAR CARCINOMA by Reichl, P, Dengler, M, van Zijl, F, Reichel, C, Huber, H, Sieghart, W, Peck-Radosavljevic, M, Grubinger, M, Mikulits, W

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P1170 : The role of growth hormone receptor in liver fibrosis and cancer by Stiedl, P, McMahon, R, Blaas, L, Stanek, V, Svinka, J, Grabner, B, Zollner, G, Kressler, S, Claudel, T, Müller, M, Mikulits, W, Esterbauer, H, Eferl, R, Haybaeck, J, Trauner, M, Casanova, E

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