Search Results - "Mikulec, Kathy"

A collagen–hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates by Murphy, Ciara M., Schindeler, Aaron, Gleeson, John P., Yu, Nicole Y.C., Cantrill, Laurence C., Mikulec, Kathy, Peacock, Lauren, O’Brien, Fergal J., Little, David G.

“…In vitro assays confirmed delayed release of both rhBMP-2 and ZA from CHA scaffolds. In vivo, CHA scaffold delivery of rhBMP-2/ZA increased bone volume in an…”
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PTH(1‐34) Treatment Increases Bisphosphonate Turnover in Fracture Repair in Rats by Murphy, Ciara M, Schindeler, Aaron, Cantrill, Laurence C, Mikulec, Kathy, Peacock, Lauren, Little, David G

“…Bisphosphonates (BP) are antiresorptive drugs with a high affinity for bone. Despite the therapeutic success in treating osteoporosis and metabolic bone…”
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CSA-90 Promotes Bone Formation and Mitigates Methicillin-resistant Staphylococcus aureus Infection in a Rat Open Fracture Model by Mills, Rebecca, Cheng, Tegan L, Mikulec, Kathy, Peacock, Lauren, Isaacs, David, Genberg, Carl, Savage, Paul B, Little, David G, Schindeler, Aaron

“…Infection of open fractures remains a significant cause of morbidity and mortality to patients worldwide. Early administration of prophylactic antibiotics is…”
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Sclerostin antibody enhances bone formation in a rat model of distraction osteogenesis by McDonald, Michelle M., Morse, Alyson, Birke, Oliver, Yu, Nicole Y. C., Mikulec, Kathy, Peacock, Lauren, Schindeler, Aaron, Liu, Min, Ke, Hua Z., Little, David G.

“…ABSTRACT Neutralizing monoclonal sclerostin antibodies are effective in promoting bone formation at a systemic level and in orthopedic scenarios including…”
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Myogenic progenitors contribute to open but not closed fracture repair by Liu, Renjing, Birke, Oliver, Morse, Alyson, Peacock, Lauren, Mikulec, Kathy, Little, David G, Schindeler, Aaron

“…Bone repair is dependent on the presence of osteocompetent progenitors that are able to differentiate and generate new bone. Muscle is found in close…”
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Lineage tracking of mesenchymal and endothelial progenitors in BMP-induced bone formation by Kolind, Mille, Bobyn, Justin D, Matthews, Brya G, Mikulec, Kathy, Aiken, Alastair, Little, David G, Kalajzic, Ivo, Schindeler, Aaron

“…Abstract To better understand the relative contributions of mesenchymal and endothelial progenitor cells to rhBMP-2 induced bone formation, we examined the…”
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Neuropeptide Y modulates fracture healing through Y1 receptor signaling by Sousa, Daniela M., McDonald, Michelle M., Mikulec, Kathy, Peacock, Lauren, Herzog, Herbert, Lamghari, Meriem, Little, David G., Baldock, Paul A.

“…Neuropeptide Y acting via it's Y1 receptor represents a powerful pathway in the control of bone mass. The global or osteoblast‐specific Y1 receptor deletion…”
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Inducible cell labeling and lineage tracking during fracture repair by Seime, Till, Kolind, Mille, Mikulec, Kathy, Summers, Matthew A., Cantrill, Laurence, Little, David G., Schindeler, Aaron

“…Mouse models incorporating inducible Cre‐ERT2/LoxP recombination coupled with sensitive fluorescent reporter lines are being increasingly used to track cell…”
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Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs by Cheng, Tegan L., Murphy, Ciara M., Cantrill, Laurence C., Mikulec, Kathy, Carpenter, Clare, Schindeler, Aaron, Little, David G.

“…Purpose Legg-Calve-Perthes disease is a paediatric condition encompassing idiopathic osteonecrosis of the femoral head (ONFH). Preventing collapse and the need…”
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Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics by Schindeler, Aaron, Morse, Alyson, Peacock, Lauren, Mikulec, Kathy, Yu, Nicole Y C, Liu, Renjing, Kijumnuayporn, Sandy, McDonald, Michelle M, Baldock, Paul A, Ruys, Andrew J, Little, David G

“…Transforming growth factor-beta (TGF-beta) and bone morphogenetic proteins (BMPs) utilize parallel and related signaling pathways, however the interaction…”
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Combination sclerostin antibody and zoledronic acid treatment outperforms either treatment alone in a mouse model of osteogenesis imperfecta by Little, David G, Peacock, Lauren, Mikulec, Kathy, Kneissel, Michaela, Kramer, Ina, Cheng, Tegan L, Schindeler, Aaron, Munns, Craig

“…Abstract In this study, we examined the therapeutic potential of anti-Sclerostin Antibody (Scl-Ab) and bisphosphonate treatments for the bone fragility…”
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Pretreatment with Pamidronate Decreases Bone Formation but Increases Callus Bone Volume in a Rat Closed Fracture Model by Morse, Alyson, McDonald, Michelle M., Mikulec, Kathy, Schindeler, Aaron, Munns, Craig F., Little, David G.

“…Clinical concerns have been raised over prior exposure to bisphosphonates impairing fracture healing. To model this, groups of male Wistar rats were assigned…”
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Dietary intervention rescues myopathy associated with neurofibromatosis type 1 by Summers, Matthew A, Rupasinghe, Thusitha, Vasiljevski, Emily R, Evesson, Frances J, Mikulec, Kathy, Peacock, Lauren, Quinlan, Kate G R, Cooper, Sandra T, Roessner, Ute, Stevenson, David A, Little, David G, Schindeler, Aaron

“…Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder with complex symptomology. In addition to a predisposition to tumors,…”
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Developmental dosing with a MEK inhibitor (PD0325901) rescues myopathic features of the muscle-specific but not limb-specific Nf1 knockout mouse by Summers, Matthew A., Vasiljevski, Emily R., Mikulec, Kathy, Peacock, Lauren, Little, David G., Schindeler, Aaron

“…Neurofibromatosis Type 1 (NF1) is a common autosomal dominant genetic disorder While NF1 is primarily associated with predisposition for tumor formation,…”
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Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats by McDonald, Michelle M., Morse, Alyson, Mikulec, Kathy, Peacock, Lauren, Yu, Nicole, Baldock, Paul A., Birke, Oliver, Liu, Min, Ke, Hua Zhu, Little, David G.

“…Recent studies suggest a possible role for inhibitors of sclerostin such as sclerostin antibody (Scl‐Ab) as an anabolic treatment for osteoporosis. Since…”
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RAP-011 augments callus formation in closed fractures in rats by Morse, Alyson, Cheng, Tegan L., Peacock, Lauren, Mikulec, Kathy, Little, David G., Schindeler, Aaron

“…ABSTRACT ACE‐011 is a bone anabolic agent generated by fusing the extracellular domain of the Activin Type 2A receptor (ActRIIA) to an IgG‐Fc. The orthopedic…”
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Local Delivery of the Cationic Steroid Antibiotic CSA-90 Enables Osseous Union in a Rat Open Fracture Model of Staphylococcus aureus Infection by Schindeler, Aaron, Yu, Nicole Y.C, Cheng, Tegan L, Sullivan, Kate, Mikulec, Kathy, Peacock, Lauren, Matthews, Ross, Little, David G

“…BACKGROUND:Treatment of infected open fractures remains a major clinical challenge. In this study, we investigated the novel broad-spectrum antibiotic CSA-90…”
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Sclerostin Antibody Increases Callus Size and Strength but does not Improve Fracture Union in a Challenged Open Rat Fracture Model by Morse, Alyson, McDonald, Michelle M., Schindeler, Aaron, Peacock, Lauren, Mikulec, Kathy, Cheng, Tegan L., Liu, Min, Ke, Hua Zhu, Little, David G.

“…Open fractures remain a challenge in orthopedics. Current strategies to intervene are often inadequate, particularly in severe fractures or when treatment is…”
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Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation by McDonald, Michelle M., Morse, Alyson, Schindeler, Aaron, Mikulec, Kathy, Peacock, Lauren, Cheng, Tegan, Bobyn, Justin, Lee, Lucinda, Baldock, Paul A., Croucher, Peter I., Tam, Patrick P. L., Little, David G.

“…Wnt antagonist Dkk1 is a negative regulator of bone formation and Dkk1 + / − heterozygous mice display a high bone mass phenotype. Complete loss of Dkk1…”
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Improved union and bone strength in a mouse model of NF1 pseudarthrosis treated with recombinant human bone morphogenetic protein‐2 and zoledronic acid by Deo, Nikita, Cheng, Tegan L., Mikulec, Kathy, Peacock, Lauren, Little, David G., Schindeler, Aaron

“…ABSTRACT Tibial pseudarthrosis associated with Neurofibromatosis type 1 (NF1) is an orthopedic condition with consistently poor clinical outcomes. Using a…”
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