Search Results - "Mikušová, Gabriela"
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Outer membrane and phospholipid composition of the target membrane affect the antimicrobial potential of first- and second-generation lipophosphonoxins
Published in Scientific reports (17-05-2021)“…Lipophosphonoxins (LPPOs) are small modular synthetic antibacterial compounds that target the cytoplasmic membrane. First-generation LPPOs (LPPO I) exhibit an…”
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Bacillus subtilis cardiolipin protects its own membrane against surfactin-induced permeabilization
Published in Biochimica et biophysica acta. Biomembranes (01-10-2020)“…Surfactin, a cyclic lipoheptapeptide produced by Bacillus subtilis, is a surface-active antimicrobial that targets the barrier function of lipid membranes. It…”
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LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials
Published in Journal of medicinal chemistry (28-07-2022)“…The alarming rise of bacterial antibiotic resistance requires the development of new compounds. Such compounds, lipophosphonoxins (LPPOs), were previously…”
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R-Type Fonticins Produced by Pragia fontium Form Large Pores with High Conductance
Published in Journal of bacteriology (26-01-2023)“…Fonticins are phage tail-like bacteriocins produced by the Gram-negative bacterium Pragia fontium from the family . This bacterium produces contractile-type…”
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Colicin U from Shigella boydii Forms Voltage-Dependent Pores
Published in Journal of bacteriology (01-12-2019)“…Colicin U is a protein produced by the bacterium (serovars 1 and 8). It exerts antibacterial activity against strains of the enterobacterial genera and Here,…”
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LEGO-lipophosphonoxins: length of hydrophobic module affects permeabilizing activity in target membranes of different phospholipid composition
Published in RSC advances (10-01-2024)“…In the past few decades, society has faced rapid development and spreading of antimicrobial resistance due to antibiotic misuse and overuse and the immense…”
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Residues 529 to 549 participate in membrane penetration and pore-forming activity of the Bordetella adenylate cyclase toxin
Published in Scientific reports (08-04-2019)“…The adenylate cyclase toxin-hemolysin (CyaA, ACT or AC-Hly) of pathogenic Bordetellae delivers its adenylyl cyclase (AC) enzyme domain into the cytosol of host…”
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Semi-synthetic puwainaphycin/minutissamide cyclic lipopeptides with improved antifungal activity and limited cytotoxicity
Published in RSC advances (16-09-2021)“…Microbial cyclic lipopeptides are an important class of antifungal compounds with applications in pharmacology and biotechnology. However, the cytotoxicity of…”
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Colicin U from Shigella boydii Forms Voltage-Dependent Pores
Published in Journal of bacteriology (20-11-2019)“…Currently, a dramatic increase in antibiotic resistance is driving researchers to find new antimicrobial agents. The large group of toxins called bacteriocins…”
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