Search Results - "Miksza, Daniele"
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Interleukin 6 acutely increases gluconeogenesis and decreases the suppressive effect of insulin on cAMP‐stimulated glycogenolysis in rat liver
Published in Cell biochemistry and function (01-07-2023)“…Interleukin 6 (IL6) is an multifunctional cytokine that modulates several biological responses, including glucose metabolism. However, its acute effects on…”
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2
Insulin secretion decline in Walker-256 tumor-bearing rats is early, follows the course of cachexia, and is not improved by lixisenatide
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-04-2021)“…Lixisenatide, a glucagon-like peptide-1 receptor agonist, is used to stimulate insulin secretion in patients with type 2 diabetes mellitus. However, its effect…”
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3
Decreased hepatic response to glucagon, adrenergic agonists, and cAMP in glycogenolysis, gluconeogenesis, and glycolysis in tumor‐bearing rats
Published in Journal of cellular biochemistry (01-09-2018)“…The response to glucagon and adrenaline in cancer cachexia is poorly known. The aim of this study was to investigate the response to glucagon, adrenergic…”
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4
Effects of lixisenatide treatment on mild cachexia and related metabolic abnormalities in Walker‐256 tumour‐bearing rats
Published in Cell biochemistry and function (01-03-2021)“…Lixisenatide, a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, is used in the treatment of type 2 diabetes mellitus (T2DM). It increases insulin (INS)…”
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5
Peripheral insulin resistance is early, progressive, and correlated with cachexia in Walker‐256 tumor‐bearing rats
Published in Cell biochemistry and function (01-12-2023)“…Insulin (INS) resistance is often found in cancer‐bearing, but its correlation with cachexia development is not completely established. This study investigated…”
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6
Infusion of high concentration of lactate in perfused liver, simulating in vivo hyperlactatemia, prevents the reduction of gluconeogenesis in Walker‐256 tumor‐bearing rats
Published in Journal of cellular biochemistry (01-07-2019)“…Gluconeogenesis (GN) is increased in patients with cancer cachexia, but is reduced in liver perfusion of Walker‐256 tumor‐bearing cachectic rats (TB rats). The…”
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Gluconeogenesis is reduced from alanine, lactate and pyruvate, but maintained from glycerol, in liver perfusion of rats with early and late sepsis
Published in Cell biochemistry and function (01-08-2021)“…Sepsis induces several metabolic abnormalities, including hypoglycaemia in the most advanced stage of the disease, a risk factor for complications and death…”
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Effect of infliximab on metabolic disorders induced by Walker-256 tumor in rats
Published in Pharmacological reports (2013)“…The purpose of this study was to investigate the effect of infliximab, an anti-tumor necrosis factor a (TNFα) mono-clonal antibody, on the progression of…”
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9
Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity
Published in Pharmacological reports (01-12-2023)“…Insulin (INS) resistance and hypoinsulinemia commonly observed in cancer-carrying, can contribute to cachexia. However, the effects of INS and INS sensitizers,…”
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10
Moderate exercise training since adolescence reduces Walker 256 tumour growth in adult rats
Published in The Journal of physiology (01-08-2019)“…Key points Cancer growth, cell proliferation and cachexia index can be attenuated by the beneficial programming effect of moderate exercise training,…”
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11
Tumor necrosis factor alpha abolished the suppressive effect of insulin on hepatic glucose production and glycogenolysis stimulated by cAMP
Published in Pharmacological reports (01-06-2014)“…Tumor necrosis factor alpha (TNFα) is implicated in the development of insulin resistance in obesity, type 2 diabetes and cancer. However, its ability to…”
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Inhibitory effect of tumor necrosis factor [alpha] on gluconeogenesis in perfused rat liver
Published in Molecular and cellular biochemistry (01-03-2013)“…Tumor necrosis factor [alpha] (TNF[alpha]) is a cytokine involved in many metabolic responses in both normal and pathological states. Considering that the…”
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13
Inhibitory effect of tumor necrosis factor α on gluconeogenesis in perfused rat liver
Published in Molecular and cellular biochemistry (01-03-2013)“…Tumor necrosis factor α (TNFα) is a cytokine involved in many metabolic responses in both normal and pathological states. Considering that the effects of TNFα…”
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