Search Results - "Mikkola, Hanna KA"

Defining the nature of human pluripotent stem cell progeny by Patterson, Michaela, Chan, David N., Ha, Iris, Case, Dana, Cui, Yongyan, Handel, Ben Van, Mikkola, Hanna KA, Lowry, William E

“…While it is clear that human pluripotent stem cells （hPSCs） can differentiate to generate a panoply of various cell types, it is unknown how closely in vitro…”
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Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes by Ferguson, Gabriel B., Van Handel, Ben, Bay, Maxwell, Fiziev, Petko, Org, Tonis, Lee, Siyoung, Shkhyan, Ruzanna, Banks, Nicholas W., Scheinberg, Mila, Wu, Ling, Saitta, Biagio, Elphingstone, Joseph, Larson, A. Noelle, Riester, Scott M., Pyle, April D., Bernthal, Nicholas M., Mikkola, Hanna KA, Ernst, Jason, van Wijnen, Andre J., Bonaguidi, Michael, Evseenko, Denis

“…Tissue-specific gene expression defines cellular identity and function, but knowledge of early human development is limited, hampering application of…”
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GLI2 inhibition abrogates human leukemia stem cell dormancy by Sadarangani, Anil, Pineda, Gabriel, Lennon, Kathleen M, Chun, Hye-Jung, Shih, Alice, Schairer, Annelie E, Court, Angela C, Goff, Daniel J, Prashad, Sacha L, Geron, Ifat, Wall, Russell, McPherson, John D, Moore, Richard A, Pu, Minya, Bao, Lei, Jackson-Fisher, Amy, Munchhof, Michael, VanArsdale, Todd, Reya, Tannishtha, Morris, Sheldon R, Minden, Mark D, Messer, Karen, Mikkola, Hanna K A, Marra, Marco A, Hudson, Thomas J, Jamieson, Catriona H M

“…Dormant leukemia stem cells (LSC) promote therapeutic resistance and leukemic progression as a result of unbridled activation of stem cell gene expression…”
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Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A by Sankaran, Vijay G, Menne, Tobias F, Xu, Jian, Akie, Thomas E, Lettre, Guillaume, Van Handel, Ben, Mikkola, Hanna K.A, Hirschhorn, Joel N, Cantor, Alan B, Orkin, Stuart H

“…Differences in the amount of fetal hemoglobin (HbF) that persists into adulthood affect the severity of sickle cell disease and the β-thalassemia syndromes…”
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The journey of developing hematopoietic stem cells by Mikkola, Hanna K A, Orkin, Stuart H

“…Hematopoietic stem cells (HSCs) develop during embryogenesis in a complex process that involves multiple anatomical sites. Once HSC precursors have been…”
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Combinatorial Assembly of Developmental Stage-Specific Enhancers Controls Gene Expression Programs during Human Erythropoiesis by Xu, Jian, Shao, Zhen, Glass, Kimberly, Bauer, Daniel E., Pinello, Luca, Van Handel, Ben, Hou, Serena, Stamatoyannopoulos, John A., Mikkola, Hanna K.A., Yuan, Guo-Cheng, Orkin, Stuart H.

“…Gene-distal enhancers are critical for tissue-specific gene expression, but their genomic determinants within a specific lineage at different stages of…”
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Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence by Org, Tõnis, Duan, Dan, Ferrari, Roberto, Montel-Hagen, Amelie, Van Handel, Ben, Kerényi, Marc A, Sasidharan, Rajkumar, Rubbi, Liudmilla, Fujiwara, Yuko, Pellegrini, Matteo, Orkin, Stuart H, Kurdistani, Siavash K, Mikkola, Hanna KA

“…Scl/Tal1 confers hemogenic competence and prevents ectopic cardiomyogenesis in embryonic endothelium by unknown mechanisms. We discovered that Scl binds to…”
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The hematopoietic stem cell and its niche: a comparative view by Martinez-Agosto, Julian A, Mikkola, Hanna K A, Hartenstein, Volker, Banerjee, Utpal

“…Stem cells have been identified as a source of virtually all highly differentiated cells that are replenished during the lifetime of an animal. The critical…”
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Dynamic distribution of linker histone H1.5 in cellular differentiation by Li, Jing-Yu, Patterson, Michaela, Mikkola, Hanna K A, Lowry, William E, Kurdistani, Siavash K

“…Linker histones are essential components of chromatin, but the distributions and functions of many during cellular differentiation are not well understood…”
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Regulated expression of microRNAs-126/126 inhibits erythropoiesis from human embryonic stem cells by Huang, Xinqiang, Gschweng, Eric, Van Handel, Ben, Cheng, Donghui, Mikkola, Hanna K.A., Witte, Owen N.

“…MicroRNAs (miRs) play an important role in cell differentiation and maintenance of cell identity, but relatively little is known of their functional role in…”
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Return to youth with Sox17 by Chhabra, Akanksha, Mikkola, Hanna K A

“…Maturation of hematopoietic stem cells (HSCs) from fetal to adult state and differentiation to progenitors are thought to follow a one-way street. In this…”
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Placenta as a newly identified source of hematopoietic stem cells by Lee, Lydia K, Ueno, Masaya, Van Handel, Ben, Mikkola, Hanna KA

“…PURPOSE OF REVIEWThe lifelong stream of all blood cells originates from the pool of hematopoietic stem cells (HSCs) generated during embryogenesis. Given that…”
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Analysis of cardiomyocyte clonal expansion during mouse heart development and injury by Sereti, Konstantina-Ioanna, Nguyen, Ngoc B., Kamran, Paniz, Zhao, Peng, Ranjbarvaziri, Sara, Park, Shuin, Sabri, Shan, Engel, James L., Sung, Kevin, Kulkarni, Rajan P., Ding, Yichen, Hsiai, Tzung K., Plath, Kathrin, Ernst, Jason, Sahoo, Debashis, Mikkola, Hanna K.A., Iruela-Arispe, M. Luisa, Ardehali, Reza

“…The cellular mechanisms driving cardiac tissue formation remain poorly understood, largely due to the structural and functional complexity of the heart. It is…”
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