Search Results - "Mikkelsen, Gitte K"

Design and Synthesis of Pyrrolo[2,3‑d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate by Williamson, Douglas S, Smith, Garrick P, Mikkelsen, Gitte K, Jensen, Thomas, Acheson-Dossang, Pamela, Badolo, Lassina, Bedford, Simon T, Chell, Victoria, Chen, I-Jen, Dokurno, Pawel, Hentzer, Morten, Newland, Samantha, Ray, Stuart C, Shaw, Terry, Surgenor, Allan E, Terry, Lindsey, Wang, Yikang, Christensen, Kenneth V

“…Inhibitors of leucine-rich repeat kinase 2 (LRRK2) and mutants, such as G2019S, have potential utility in Parkinson’s disease treatment. Fragment hit-derived…”
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Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist by Sams, Anette G, Mikkelsen, Gitte K, Larsen, Mogens, Langgård, Morten, Howells, Mark E, Schrøder, Tenna J, Brennum, Lise T, Torup, Lars, Jørgensen, Erling B, Bundgaard, Christoffer, Kreilgård, Mads, Bang-Andersen, Benny

“…The discovery and structure-activity relationship of a series of hA(2A) receptor antagonists is described. Compound 28 was selected from the series as a potent…”
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Discovery of N -{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M 1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential by Sams, Anette G., Hentzer, Morten, Mikkelsen, Gitte K., Larsen, Krestian, Bundgaard, Christoffer, Plath, Niels, Christoffersen, Claus T., Bang-Andersen, Benny

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Discovery of Phosphoric Acid Mono-{2-[( E / Z )-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} Ester (Lu AA47070): A Phosphonooxymethylene Prodrug of a Potent and Selective hA 2A Receptor Antagonist by Sams, Anette G., Mikkelsen, Gitte K., Larsen, Mogens, Langgård, Morten, Howells, Mark E., Schrøder, Tenna J., Brennum, Lise T., Torup, Lars, Jørgensen, Erling B., Bundgaard, Christoffer, Kreilgård, Mads, Bang-Andersen, Benny

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Discovery of N-{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential by Sams, Anette G, Hentzer, Morten, Mikkelsen, Gitte K, Larsen, Krestian, Bundgaard, Christoffer, Plath, Niels, Christoffersen, Claus T, Bang-Andersen, Benny

“…The discovery and structure−activity relationship (SAR) of a series of allosteric muscarinic M1 receptor agonists are described. Compound 17 (Lu AE51090) was…”
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Discovery of Phosphoric Acid Mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} Ester (Lu AA47070): A Phosphonooxymethylene Prodrug of a Potent and Selective hA2A Receptor Antagonist by Sams, Anette G, Mikkelsen, Gitte K, Larsen, Mogens, Langgård, Morten, Howells, Mark E, Schrøder, Tenna J, Brennum, Lise T, Torup, Lars, Jørgensen, Erling B, Bundgaard, Christoffer, Kreilgård, Mads, Bang-Andersen, Benny

“…The discovery and structure−activity relationship of a series of hA2A receptor antagonists is described. Compound 28 was selected from the series as a potent…”
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