Search Results - "Mikihisa TAKANO"

Role of Nrf2 in Methotrexate-Induced Epithelial–Mesenchymal Transition in Alveolar A549 Cells by Kawami, Masashi, Honda, Mikito, Hara, Takuya, Yumoto, Ryoko, Takano, Mikihisa

“…Methotrexate (MTX) is known to induce serious lung diseases, such as pulmonary fibrosis. Although we demonstrated that MTX is associated with…”
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Effect of Corticosteroids on Peptide Transporter 2 Function and Induction of Innate Immune Response by Bacterial Peptides in Alveolar Epithelial Cells by Takano, Mikihisa, Kuriyama, Shiori, Kameda, Nanako, Kawami, Masashi, Yumoto, Ryoko

“…In the lung alveolar region, the innate immune system serves as an important host defense system. We recently reported that peptide transporter 2 (PEPT2) has…”
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Role of peptide transporter 2 and MAPK signaling pathways in the innate immune response induced by bacterial peptides in alveolar epithelial cells by Takano, Mikihisa, Takeuchi, Tomoya, Kuriyama, Shiori, Yumoto, Ryoko

“…The innate immune response induced by bacterial peptidoglycan peptides, such as γ-d-glutamyl-meso-diaminopimelic acid (iE-DAP), is an important host defense…”
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Direct N1-Selective Alkylation of Hydantoins Using Potassium Bases by Shintani, Yumi, Kato, Koichi, Kawami, Masashi, Takano, Mikihisa, Kumamoto, Takuya

“…Hydantoins, including the antiepileptic drug phenytoin, contain an amide nitrogen and an imide nitrogen, both of which can be alkylated. However, due to the…”
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Molecular Aspects of Renal Handling of Aminoglycosides and Strategies for Preventing the Nephrotoxicity by Nagai, Junya, Takano, Mikihisa

“…Aminoglycosides such as gentamicin and amikacin are the most commonly used antibiotics worldwide in the treatment of Gram-negative bacterial infections…”
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Role of plasminogen activator inhibitor-1 in methotrexate-induced epithelial-mesenchymal transition in alveolar epithelial A549 cells by Yamagami, Yohei, Kawami, Masashi, Ojima, Takamichi, Futatsugi, Sorahito, Yumoto, Ryoko, Takano, Mikihisa

“…There is increasing evidence that epithelial-mesenchymal transition (EMT) contributes to the development of organ fibrosis. We demonstrated that methotrexate…”
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Expression and function of efflux drug transporters in the intestine by Takano, Mikihisa, Yumoto, Ryoko, Murakami, Teruo

“…A variety of drug transporters expressed in the body control the fate of drugs by affecting absorption, distribution, and elimination processes. In the small…”
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Differential mechanisms underlying methotrexate-induced cell death and epithelial-mesenchymal transition in A549 cells by Ojima, Takamichi, Kawami, Masashi, Yumoto, Ryoko, Takano, Mikihisa

“…Epithelial-mesenchymal transition (EMT), a biological process through which epithelial cells transdifferentiate into mesenchymal cells, is involved in several…”
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Effect of transforming growth factor-β1 on functional expression of monocarboxylate transporter 1 in alveolar epithelial A549 cells by Uddin, Mohi, Kawami, Masashi, Yumoto, Ryoko, Takano, Mikihisa

“…Epithelial-mesenchymal transition (EMT) contributes to the development of severe lung diseases, such as pulmonary fibrosis. Recently, it has been reported that…”
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Evaluation on epithelial-mesenchymal state and microRNAs focusing on isolated alveolar epithelial cells from bleomycin injured rat lung by Kawami, Masashi, Takenaka, Shinnosuke, Kadekaru, Yuri, Akai, Mizuki, Konaka, Takashi, Yumoto, Ryoko, Takano, Mikihisa

“…[Display omitted] •Intratracheal BLM administration induced EMT in purified ATII cells from the rat.•EMT in ATII cells occurred in prior to development of…”
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Role of miR-34a in TGF-β1- and Drug-Induced Epithelial-Mesenchymal Transition in Alveolar Type II Epithelial Cells by Takano, Mikihisa, Nekomoto, Chinami, Kawami, Masashi, Yumoto, Ryoko

“…Epithelial-mesenchymal transition (EMT) of alveolar type II epithelial cells may play an important role in the pulmonary fibrosis induced by drugs such as…”
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miR-484: A Possible Indicator of Drug-Induced Pulmonary Fibrosis by Konaka, Takashi, Kawami, Masashi, Yamamoto, Ayano, Yumoto, Ryoko, Takano, Mikihisa

“…Drug-induced lung injury leads to serious lung diseases, such as pulmonary fibrosis. We demonstrated in an alveolar epithelial cell line A549/ABCA3 that…”
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A Liquid Chromatography-Mass Spectrometry Method to Study the Interaction between Membrane Proteins and Low-Molecular-Weight Compound Mixtures by Ogiso, Hideo, Suno, Ryoji, Kobayashi, Takuya, Kawami, Masashi, Takano, Mikihisa, Ogasawara, Masaru

“…Molecular interaction analysis is an essential technique for the study of biomolecular functions and the development of new drugs. Most current methods…”
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Functional Expression of PEPT2 in the Human Distal Lung Epithelial Cell Line NCl-H441 by Takano, Mikihisa, Sugimoto, Natsumi, Ehrhardt, Carsten, Yumoto, Ryoko

“…Purpose The peptide transporter PEPT2 is expressed in alveolar type II epithelial cells. So far, however, no appropriate alveolar epithelial cell line for…”
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Suppressive effect of quercetin against bleomycin-induced epithelial-mesenchymal transition in alveolar epithelial cells by Takano, Mikihisa, Deguchi, Junya, Senoo, Shunsuke, Izumi, Miho, Kawami, Masashi, Yumoto, Ryoko

“…Quercetin is a flavonol that is known to have numerous beneficial biological effects such as an anti-fibrotic effect. Epithelial-mesenchymal transition (EMT)…”
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Nicotine transport in lung and non-lung epithelial cells by Takano, Mikihisa, Kamei, Hidetaka, Nagahiro, Machi, Kawami, Masashi, Yumoto, Ryoko

“…Nicotine is rapidly absorbed from the lung alveoli into systemic circulation during cigarette smoking. However, mechanism underlying nicotine transport in…”
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Transport Mechanism of Nicotine in Primary Cultured Alveolar Epithelial Cells by Takano, Mikihisa, Nagahiro, Machi, Yumoto, Ryoko

“…Nicotine is absorbed from the lungs into the systemic circulation during cigarette smoking. However, there is little information concerning the transport…”
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Investigation on inhibitory effect of folic acid on methotrexate-induced epithelial-mesenchymal transition focusing on dihydrofolate reductase by Kawami, Masashi, Honda, Natsuko, Hara, Takuya, Yumoto, Ryoko, Takano, Mikihisa

“…Use of methotrexate (MTX) can induce serious adverse lung reactions, such as pulmonary fibrosis. Recently, we demonstrated that the epithelial-mesenchymal…”
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Reduced folate carrier‐mediated methotrexate transport in human distal lung epithelial NCl‐H441 cells by Kawami, Masashi, Honda, Natsuko, Miyamoto, Mioka, Yumoto, Ryoko, Takano, Mikihisa

“…Objectives We had previously found that reduced folate carrier (RFC; SLC19A1) is mainly involved in an influx of transport of methotrexate (MTX), a folate…”
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Anticancer Drug-Induced Epithelial-Mesenchymal Transition via p53/miR-34a axis in A549/ABCA3 Cells by Yamamoto, Ayano, Kawami, Masashi, Konaka, Takashi, Takenaka, Shinnosuke, Yumoto, Ryoko, Takano, Mikihisa

“…Several anticancer drugs including bleomycin (BLM) and methotrexate (MTX) cause serious lung diseases such as pulmonary fibrosis. Although evidences showing…”
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