Search Results - "Mikashima, H"

Effect of Y-20811, a thromboxane synthetase inhibitor, on photochemically induced cerebral embolism in rabbits by Fujimura, M, Mikashima, H

“…The effect of Y-20811, a selective thromboxane A2 synthetase inhibitor, was investigated on cerebral embolism using a new model of embolic cerebral infarction…”
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Inhibitory effect of 2-(4-(2-imidazo(1,2-a)pyridyl)phenyl) propionic acid (miroprofen) on platelet aggregation and prostaglandin I2 generation (author's transl) by Mikashima, H, Goto, K

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Thromboxane synthetase inhibitors. I. Synthesis of some imidazolylarylmethanols and their inhibitory activity on platelet aggregation by Tsuruda, M, Mikashima, H, Oe, T, Kawasaki, K, Setoguchi, S, Naka, Y, Tahara, T

“…Several imidazolylpyridinemethanols and imidazolylbenzenemethanols were prepared and evaluated for an inhibitory activity against arachidonic acid-induced…”
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Pharmacokinetics of sodium 4-[alpha-hydroxy-5-(1-imidazolyl)-2-methylbenzyl-3,5-dimethylbenzoate (Y-20811), a new thromboxane synthetase inhibitor. II. Pharmacokinetics of intact drug and main metabolite in dog by Iwata, T, Mikashima, H, Isobe, M, Takamatsu, R, Yokobe, T

“…The pharmacokinetics of sodium 4-[alpha-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoat e (I-Na) in the beagle dog was investigated after p.o. and…”
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Effects of Y-20811, a specific thromboxane A2 synthetase inhibitor, on chemical mediator-induced bronchoconstriction in guinea pigs by Kagoshima, M, Tomomatsu, N, Fukuda, T, Mikashima, H, Terasawa, M

“…We investigated the effects of Y-20811 on chemical mediator-induced bronchoconstriction and the release of chemical mediators into lung perfusion fluid during…”
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Pharmacological actions of Y-24180, a new specific antagonist of platelet activating factor (PAF): II. Interactions with PAF and benzodiazepine receptors by Takehara, S, Mikashima, H, Muramoto, Y, Terasawa, M, Setoguchi, M, Tahara, T

“…The inhibitory effect of Y-24180, 4-(2-chlorophenyl)-2-[2-(4-isobutylphenyl)ethyl]-6,9-dimethyl-6H-t hieno [3,2-f][1,2,4]triazolo [4,3-a][1,4]diazepine, on…”
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Inhibitory Effect of 2-(5H-[1] Benzopyrano [2, 3-b] pyridin-7-yl) propionic Acid (Pranoprofen) on Platelet Aggregation by GOTO, KAZUHIRO, MIKASHIMA, HIROSHI, TERASAWA, MICHIO, MARUYAMA, YUTAKA

“…Addition of arachidonic acid (0.1 mM) to a washed platelet suspension obtained from guinea pigs resulted in platelet aggregation and formation of…”
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Protective effect of Y-20811, a long-lasting thromboxane synthetase inhibitor, on endotoxin shock in rabbits by Mikashima, H, Muramoto, Y

“…The effect of sodium 4-[alpha-hydroxy-5-(imidazolyl)-2-methylbenzyl]-3,5-dimethyl benzoate dihydrate (Y-20811), a selective thromboxane (TX) synthetase…”
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Correlation between pharmacokinetics and pharmacologic effects of a new imidazole thromboxane synthetase inhibitor by Iwata, T, Mikashima, H, Takamatsu, R

“…A new imidazole derivative, sodium 4-[alpha-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylbenzoat e dihydrate (1; Y-20811), is a potent selective…”
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Irreversible inhibition of thromboxane (TX) A2 synthesis by Y-20811, a selective TX synthetase inhibitor by Mikashima, H, Ochi, H, Muramoto, Y, Hirotsu, K, Arima, N

“…As Y-20811, sodium (+-)-4-[alpha-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3,5-dimethylb+ ++ enzoic acid, has been reported to inhibit serum thromboxane (TX) A2…”
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Effects of Y-20811, a long-lasting thromboxane synthetase inhibitor, on thromboxane production and platelet function by Mikashima, H, Ochi, H, Muramoto, Y, Yasuda, H, Tsuruta, M, Maruyama, Y

“…Effects of a new imidazole derivative, sodium 4-[alpha-hydroxy-5-(imidazolyl)-2-methylbenzyl]-3,5-dimethyl benzoate dihydrate (Y-20811), on thromboxane (TX)…”
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PAF antagonistic activity of some thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4¿iazepines by TAHARA, T, MIKASHIMA, H, TERASAWA, M, MARUYAMA, Y

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PAF ANTAGONISTIC ACTIVITY OF SOME THIENO [3, 2-f] [1, 2, 4] TRIAZOLO [4, 3-a] [1, 4] DIAZEPINES by Tahara, Tetsuya, Mikashima, Hiroshi, Terasawa, Michio, Maruyama, Yutaka

“…Some thieno [3, 2-f] [1, 2, 4] triazolo [4, 3-a] [1, 4] diazepines were antagonistic to PAF-induced platelet aggregation in rabbit PRP and bronchoconstriction…”
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Inhibitory Effect of 2-{4-(2-Imidazo [1, 2-α] pyridyl) phenyl} propionic Acid (Miroprofen) on Platelet Aggregation and Prostaglandin I2 Generation by MIKASHIMA, HIROSHI, GOTO, KAZUHIRO

“…Addition of adenosine diphosphate (2 μM) and adrenaline (5 μM) to human plateletrich plasma (PRP) resulted in biphasic aggregation in vitro. The preincubation…”
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Y-590 (a new pyridazinone derivative), a potent anti-thrombotic agent--II. Inhibition of platelet phosphodiesterase by Mikashima, H, Nakao, T, Goto, K, Ochi, H, Yasuda, H, Tsumagari, T

“…The effects of 6-(2, 3, 4, 5-tetrahydro-5-methyl-3-oxo-pyridazine-6-yl)-1, 2, 3, 4-tetrahydro -1-methyl quinolin-2-one (Y-590) on platelet phosphodiesterases…”
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Pharmacokinetics of Sodium 4-[α-Hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3, 5-dimethylbenzoate (Y-20811), a New Thromboxane Synthetase Inhibitor. II. Pharmacokinetics of Intact Drug and Main Metabolite in Dog by IWATA, Toshio, MIKASHIMA, Hiroshi, ISOBE, Masao, TAKAMATSU, Rikuo, YOKOBE, Tetsuo

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Antagonistic Activity of Etizolam on Platelet-Activating Factor In Vivo Experiments by TERASAWA, Michio, MIKASHIMA, Hiroshi, TAHARA, Tetsuya, MARUYAMA, Yutaka

“…The ability of etizolam. 6-(o-chlorophenyl)-8-ethyl-1-methyl-4H-s-triazolo[3,4-c]thieno[2,3-e][1,4]diazepine (Y-7131), an anti-anxiety drug, to inhibit…”
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An Antagonistic Activity of Etizolam on Platelet-Activating Factor (PAF) In Vitro Effects on Platelet Aggregation and PAF Receptor Binding by MIKASHIMA, Hiroshi, TAKEHARA, Shüzö, MURAMOTO, Yoshito, KHOMARU, Takako, TERASAWA, Michio, TAHARA, Tetsuya, MARUYAMA, Yutaka

“…The antagonistic effect of etizolam, an anti-anxiety drug, on platelet-activating factor (PAF) was investigated in rabbit platelets in vitro. Etizolam…”
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