Search Results - "Mikami, Yohei"

A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease by Kanai, Takanori, Mikami, Yohei, Hayashi, Atsushi

“…Intestinal immune homeostasis is regulated by gut microbiota, including beneficial and pathogenic microorganisms. Imbalance in gut bacterial constituents…”
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Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition by Fujii, Masayuki, Matano, Mami, Toshimitsu, Kohta, Takano, Ai, Mikami, Yohei, Nishikori, Shingo, Sugimoto, Shinya, Sato, Toshiro

“…Cellular diversity that shapes tissue architecture and function is governed by multiple niche signals. Nonetheless, maintaining cellular diversity in human…”
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Organ and brain crosstalk: The liver-brain axis in gastrointestinal, liver, and pancreatic diseases by Matsubara, Yuta, Kiyohara, Hiroki, Teratani, Toshiaki, Mikami, Yohei, Kanai, Takanori

“…The liver is the largest organ in the human body and is responsible for the metabolism and storage of the three principal nutrients: carbohydrates, fats, and…”
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CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells by Koda, Yuzo, Teratani, Toshiaki, Chu, Po-Sung, Hagihara, Yuya, Mikami, Yohei, Harada, Yosuke, Tsujikawa, Hanako, Miyamoto, Kentaro, Suzuki, Takahiro, Taniki, Nobuhito, Sujino, Tomohisa, Sakamoto, Michiie, Kanai, Takanori, Nakamoto, Nobuhiro

“…Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease that can progress to liver fibrosis. Recent clinical advance suggests a…”
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Neuroimmune crosstalk in the gut and liver by Teratani, Toshiaki, Mikami, Yohei, Kanai, Takanori

“…Abstract It has long been assumed that the nervous system exerts distinct effects on immune functions, given the large number of immune disorders that are…”
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Vagus nerve-mediated intestinal immune regulation: therapeutic implications of inflammatory bowel diseases by Mikami, Yohei, Tsunoda, Junya, Kiyohara, Hiroki, Taniki, Nobuhito, Teratani, Toshiaki, Kanai, Takanori

“…Abstract The pathophysiology of inflammatory bowel diseases (IBDs) involves immunological, genetic and environmental factors. Through its ability to sense…”
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Circadian rhythms in the tissue-specificity from metabolism to immunity: insights from omics studies by Kinouchi, Kenichiro, Mikami, Yohei, Kanai, Takanori, Itoh, Hiroshi

“…Creatures on earth have the capacity to preserve homeostasis in response to changing environments. The circadian clock enables organisms to adapt to daily…”
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Network Approaches to Uncover Pathogenesis and Therapeutic Targets of Inflammatory Bowel Diseases by Mikami, Yohei, Kanai, Takanori

“…Inflammatory bowel diseases (IBD) are currently recognized to involve chronic intestinal inflammation in genetically susceptible individuals. Patients with IBD…”
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The liver–brain–gut neural arc maintains the Treg cell niche in the gut by Teratani, Toshiaki, Mikami, Yohei, Nakamoto, Nobuhiro, Suzuki, Takahiro, Harada, Yosuke, Okabayashi, Koji, Hagihara, Yuya, Taniki, Nobuhito, Kohno, Keita, Shibata, Shinsuke, Miyamoto, Kentaro, Ishigame, Harumichi, Chu, Po-Sung, Sujino, Tomohisa, Suda, Wataru, Hattori, Masahira, Matsui, Minoru, Okada, Takaharu, Okano, Hideyuki, Inoue, Masayuki, Yada, Toshihiko, Kitagawa, Yuko, Yoshimura, Akihiko, Tanida, Mamoru, Tsuda, Makoto, Iwasaki, Yusaku, Kanai, Takanori

“…Recent clinical and experimental evidence has evoked the concept of the gut–brain axis to explain mutual interactions between the central nervous system and…”
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Molecular Dynamics Simulations of Asphaltenes at the Oil–Water Interface: From Nanoaggregation to Thin-Film Formation by Mikami, Yohei, Liang, Yunfeng, Matsuoka, Toshifumi, Boek, Edo S

“…We have investigated the interfacial behavior of asphaltene molecules at the oil–water interface using molecular dynamics simulations. Oil precipitants and…”
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Significance of 5-Aminosalicylic Acid Intolerance in the Clinical Management of Ulcerative Colitis by Mikami, Yohei, Tsunoda, Junya, Suzuki, Shohei, Mizushima, Ichiro, Kiyohara, Hiroki, Kanai, Takanori

“…Two major types of 5-aminosalicylic acid (5-ASA)-containing preparations, namely, mesalazine/5-ASA and sulfasalazine (SASP), are currently used as first-line…”
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Environmental arginine controls multinuclear giant cell metabolism and formation by Brunner, Julia S., Vulliard, Loan, Hofmann, Melanie, Kieler, Markus, Lercher, Alexander, Vogel, Andrea, Russier, Marion, Brüggenthies, Johanna B., Kerndl, Martina, Saferding, Victoria, Niederreiter, Birgit, Junza, Alexandra, Frauenstein, Annika, Scholtysek, Carina, Mikami, Yohei, Klavins, Kristaps, Krönke, Gerhard, Bergthaler, Andreas, O’Shea, John J., Weichhart, Thomas, Meissner, Felix, Smolen, Josef S., Cheng, Paul, Yanes, Oscar, Menche, Jörg, Murray, Peter J., Sharif, Omar, Blüml, Stephan, Schabbauer, Gernot

“…Multinucleated giant cells (MGCs) are implicated in many diseases including schistosomiasis, sarcoidosis and arthritis. MGC generation is energy intensive to…”
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Heterogeneity of ILC2s in the Intestine; Homeostasis and Pathology by Sunaga, Shogo, Tsunoda, Junya, Teratani, Toshiaki, Mikami, Yohei, Kanai, Takanori

“…Group 2 innate lymphoid cells (ILC2s) were identified in 2010 as a novel lymphocyte subset lacking antigen receptors, such as T-cell or B-cell receptors. ILC2s…”
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A Single Strain of Clostridium butyricum Induces Intestinal IL-10-Producing Macrophages to Suppress Acute Experimental Colitis in Mice by Hayashi, Atsushi, Sato, Toshiro, Kamada, Nobuhiko, Mikami, Yohei, Matsuoka, Katsuyoshi, Hisamatsu, Tadakazu, Hibi, Toshifumi, Roers, Axel, Yagita, Hideo, Ohteki, Toshiaki, Yoshimura, Akihiko, Kanai, Takanori

“…Imbalance in gut bacterial composition provokes host proinflammatory responses causing diseases such as colitis. Colonization with a mixture of Clostridium…”
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A Single Species of Clostridium Subcluster XIVa Decreased in Ulcerative Colitis Patients by Takeshita, Kozue, Mizuno, Shinta, Mikami, Yohei, Sujino, Tomohisa, Saigusa, Keiichiro, Matsuoka, Katsuyoshi, Naganuma, Makoto, Sato, Tadashi, Takada, Toshihiko, Tsuji, Hirokazu, Kushiro, Akira, Nomoto, Koji, Kanai, Takanori

“…Imbalance of the intestinal microbiota is associated with gastrointestinal disease and autoimmune disease and metabolic syndrome. Analysis of the intestinal…”
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Bacteriotherapy for inflammatory bowel disease by Yoshimatsu, Yusuke, Mikami, Yohei, Kanai, Takanori

“…The number of patients with inflammatory bowel disease is rapidly increasing in developed countries. The main cause of this increase is thought not to be…”
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Immune aspects of the pathogenesis of inflammatory bowel disease by HISAMATSU, Tadakazu, KANAI, Takanori, MIKAMI, Yohei, YONENO, Kazuaki, MATSUOKA, Katsuyoshi, HIBI, Toshifumi

“…Although the precise etiologies of inflammatory bowel disease (IBD) (ulcerative colitis and Crohn's disease) remain obscure, several reports have indicated…”
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Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice by Hayashi, Atsushi, Mikami, Yohei, Miyamoto, Kentaro, Kamada, Nobuhiko, Sato, Toshiro, Mizuno, Shinta, Naganuma, Makoto, Teratani, Toshiaki, Aoki, Ryo, Fukuda, Shinji, Suda, Wataru, Hattori, Masahira, Amagai, Masayuki, Ohyama, Manabu, Kanai, Takanori

“…Metabolism by the gut microbiota affects host physiology beyond the gastrointestinal tract. Here, we find that antibiotic-induced dysbiosis, in particular,…”
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Significance of endoscopic deep small bowel evaluation using balloon-assisted enteroscopy for Crohn’s disease in clinical remission by Takabayashi, Kaoru, Hosoe, Naoki, Kato, Motohiko, Hayashi, Yukie, Nanki, Kosaku, Fukuhara, Kayoko, Mikami, Yohei, Mizuno, Shinta, Sujino, Tomohisa, Mutaguchi, Makoto, Naganuma, Makoto, Yahagi, Naohisa, Ogata, Haruhiko, Kanai, Takanori

“…Background Small bowel lesions of Crohn’s disease (CD) are known to be associated with a poor prognosis; however, endoscopic healing leads to favorable…”
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Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35 by Koda, Yuzo, Nakamoto, Nobuhiro, Chu, Po-Sung, Ugamura, Aya, Mikami, Yohei, Teratani, Toshiaki, Tsujikawa, Hanako, Shiba, Shunsuke, Taniki, Nobuhito, Sujino, Tomohisa, Miyamoto, Kentaro, Suzuki, Takahiro, Yamaguchi, Akihiro, Morikawa, Rei, Sato, Katsuaki, Sakamoto, Michiie, Yoshimoto, Takayuki, Kanai, Takanori

“…Acute liver failure (ALF) is a life-threatening condition, and liver transplantation is the only therapeutic option. Although immune dysregulation is central…”
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