Search Results - "Mikami, Tadayoshi"

Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain by YAMAMOTO, Watam, MIKAMI, Tadayoshi, IWAMURA, Hiroyuki

“…We sought to examine the involvement of central cannabinoid CB2 receptor activation in modulating mechanical allodynia in a mouse model of neuropathic pain…”
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5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-alpha]pyridine-8-carboxamide (CJ-033,466), a novel and selective 5-hydroxytryptamine4 receptor partial agonist: pharmacological profile in vitro and gastroprokinetic effect in conscious dogs by Mikami, Tadayoshi, Ochi, Yasuo, Suzuki, Keiko, Saito, Toshiyuki, Sugie, Yutaka, Sakakibara, Minoru

“…5-Hydroxytryptamine (5-HT) receptors and dopamine(2) (D(2)) receptor modulate gastrointestinal motility. Gastroprokinetic agents that act on several 5-HT…”
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Contribution of Active and Inactive States of the Human 5-HT4d Receptor to the Functional Activities of 5-HT4–Receptor Agonists by Mikami, Tadayoshi, Sugimoto, Hiromi, Naganeo, Rie, Ohmi, Takashi, Saito, Toshiyuki, Eda, Hiroyuki

“…In the present study, binding affinities of 5-hydroxytryptamine-4 (5-HT4) ligands for the human 5-HT4d receptor were determined using the agonist [3H]5-HT and…”
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Biochemical and immunohistological changes in the brain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse by Araki, Tsutomu, Mikami, Tadayoshi, Tanji, Hiroaki, Matsubara, Mitsunobu, Imai, Yutaka, Mizugaki, Michinao, Itoyama, Yasuto

“…We investigated neurochemically and neuropathologically the utility of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice as a model of…”
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Pharmacological and clinical profile of inclisiran sodium, a long-acting LDL cholesterol lowering siRNA, LEQVIO for s.c. injection syringe 300 ‍mg by Mikami, Tadayoshi, Fujiwara, Yukari, Akahori, Mizuki, Tomimatsu, Naoko, Tamaki, Yuko

“…Inclisiran sodium (Brand name: LEQVIO for s.c. injection syringe 300 ‍mg, hereinafter referred to as inclisiran), a small interfering ribonucleic acid (siRNA)…”
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T+31C polymorphism of angiotensinogen gene and nocturnal blood pressure decline: the Ohasama study by Fujiwara, Tohru, Katsuya, Tomohiro, Matsubara, Mitsunobu, Mikami, Tadayoshi, Ishikawa, Kazuhiko, Kikuya, Masahiro, Ohkubo, Takayoshi, Hozawa, Atsushi, Michimata, Mari, Suzuki, Michiko, Metoki, Hirohito, Asayama, Kei, Araki, Tsutomu, Tsuji, Ichiro, Higaki, Jitsuo, Satoh, Hiroshi, Hisamichi, Shigeru, Ogihara, Toshio, Imai, Yutaka

“…We assessed the association between several polymorphisms of angiotensinogen gene ( AGT) and essential hypertension using ambulatory blood pressure (BP). We…”
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Involvement of central cannabinoid CB 2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain by Yamamoto, Wataru, Mikami, Tadayoshi, Iwamura, Hiroyuki

“…We sought to examine the involvement of central cannabinoid CB 2 receptor activation in modulating mechanical allodynia in a mouse model of neuropathic pain…”
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In vitro and in vivo pharmacological characterization of PF-01354082, a novel partial agonist selective for the 5-HT4 receptor by MIKAMI, Tadayoshi, KOMADA, Tohru, EDA, Hiroyuki, SAKAKIBARA, Minoru, SUGIMOTO, Hiromi, SUZUKI, Keiko, OHMI, Takashi, KIMURA, Naoji, NAGANEO, Rie, NAKATA, Eriko, NAKATANI, Keigo, TOGA, Tetsuo

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Pharmacological characterization and determination of pharmacokinetic and pharmacodynamic relationship of PF-00885706, a novel partial agonist selective for the 5-HT4 receptor by Komada, Tohru, Matsuura, Tomomi, Mikami, Tadayoshi, Suzuki, Keiko, Sugimoto, Hiromi, Kimura, Naoji, Ohmi, Takashi, Toga, Tetsuo, Nakai, Yasuhiro, Eda, Hiroyuki

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In vitro and in vivo pharmacological characterization of PF-01354082, a novel partial agonist selective for the 5-HT 4 receptor by Mikami, Tadayoshi, Komada, Tohru, Sugimoto, Hiromi, Suzuki, Keiko, Ohmi, Takashi, Kimura, Naoji, Naganeo, Rie, Nakata, Eriko, Nakatani, Keigo, Toga, Tetsuo, Eda, Hiroyuki, Sakakibara, Minoru

“…The pharmacological profile of PF-01354082, a selective 5-HT 4 receptor partial agonist, was investigated. PF-01354082 displayed high affinity for human 5-HT…”
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Pharmacological characterization and determination of pharmacokinetic and pharmacodynamic relationship of PF-00885706, a novel partial agonist selective for the 5-HT 4 receptor by Komada, Tohru, Matsuura, Tomomi, Mikami, Tadayoshi, Suzuki, Keiko, Sugimoto, Hiromi, Kimura, Naoji, Ohmi, Takashi, Toga, Tetsuo, Nakai, Yasuhiro, Eda, Hiroyuki, Sakakibara, Minoru

“…The pharmacological profile of PF-00885706, a selective 5-HT 4 receptor partial agonist, was investigated. PF-00885706 displayed a high binding affinity for…”
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Pharmacological characterization and determination of pharmacokinetic and pharmacodynamic relationship of PF-00885706, a novel partial agonist selective for the 5-HT(4) receptor by Komada, Tohru, Matsuura, Tomomi, Mikami, Tadayoshi, Suzuki, Keiko, Sugimoto, Hiromi, Kimura, Naoji, Ohmi, Takashi, Toga, Tetsuo, Nakai, Yasuhiro, Eda, Hiroyuki, Sakakibara, Minoru

“…The pharmacological profile of PF-00885706, a selective 5-HT(4) receptor partial agonist, was investigated. PF-00885706 displayed a high binding affinity for…”
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In vitro and in vivo pharmacological characterization of PF-01354082, a novel partial agonist selective for the 5-HT(4) receptor by Mikami, Tadayoshi, Komada, Tohru, Sugimoto, Hiromi, Suzuki, Keiko, Ohmi, Takashi, Kimura, Naoji, Naganeo, Rie, Nakata, Eriko, Nakatani, Keigo, Toga, Tetsuo, Eda, Hiroyuki, Sakakibara, Minoru

“…The pharmacological profile of PF-01354082, a selective 5-HT(4) receptor partial agonist, was investigated. PF-01354082 displayed high affinity for human…”
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P-148: Genetic involvement of T+31C polymorphism in angiotensinogen gene for daytime and nighttime blood pressure: The O study by Sugimoto, Ken, Mikami, Tadayoshi, Katsuya, Tomohiro, Ohkubo, Takayoshi, Hozawa, Atsushi, Fukuda, Masayuki, Matsubara, Mitsunobu, Tsuji, Ichiro, Araki, Tsutomu, Satoh, Hiroshi, Higaki, Jitsuo, Hisamichi, Shigeru, Imai, Yutaka, Ogihara, Toshio

“…Objectives: The polymorphisms of human angiotensinogen gene were reported as genetic predisposing factors for cardiovascular disease. We recently documented…”
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Genetic involvement of T+31C polymorphism in angiotensinogen gene for daytime and nighttime blood pressure: the O study by Sugimoto, Ken, Mikami, Tadayoshi, Katsuya, Tomohiro, Ohkubo, Takayoshi, Hozawa, Atsushi, Fukuda, Masayuki, Matsubara, Mitsunobu, Tsuji, Ichiro, Araki, Tsutomu, Satoh, Hiroshi, Higaki, Jitsuo, Hisamichi, Shigeru, Imai, Yutaka, Ogihara, Toshio

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