Search Results - "Mikami, Iwao"

First-Line Gefitinib for Patients With Advanced Non–Small-Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Mutations Without Indication for Chemotherapy by INOUE, Akira, KOBAYASHI, Kunihiko, MIYAZAWA, Hitoshi, TANAKA, Tomoaki, IKEBUCHI, Kenji, NUKIWA, Toshihiro, MORITA, Satoshi, HAGIWARA, Koichi, USUI, Kazuhiro, MAEMONDO, Makoto, OKINAGA, Shoji, MIKAMI, Iwao, ANDO, Masahiro, YAMAZAKI, Koichi, SAIJO, Yasuo, GEMMA, Akihiko

“…This multicenter phase II study was undertaken to investigate the efficacy and feasibility of gefitinib for patients with advanced non-small-cell lung cancer…”
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Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations by BIAO HE, REGUART, Noemi, LIANG YOU, MAZIERES, Julien, ZHIDONG XU, LEE, Amie Y, MIKAMI, Iwao, MCCORMICK, Frank, JABLONS, David M

“…Aberrant Wnt signaling, mainly through mutations of APC and in some cases of CTNNB1 or AXIN2, has been found in the majority of colorectal cancers. Recently,…”
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Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells by LIANG YOU, BIAO HE, JABLONS, David M, ZHIDONG XU, UEMATSU, Kazutsugu, MAZIERES, Julien, MIKAMI, Iwao, REGUART, Noemi, MOODY, Terry W, KITAJEWSKI, Jan, MCCORMICK, Frank

“…In this report, we have demonstrated that Wnt-2 protein is overexpressed in freshly resected human non-small-cell lung cancer (NSCLC) tissues. We have also…”
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Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer by Zhou, Bin-Bing S., Peyton, Michael, He, Biao, Liu, Changnian, Girard, Luc, Caudler, Eian, Lo, Yvonne, Baribaud, Frederic, Mikami, Iwao, Reguart, Noemi, Yang, Gengjie, Li, Yanlong, Yao, Wenqing, Vaddi, Kris, Gazdar, Adi F., Friedman, Steven M., Jablons, David M., Newton, Robert C., Fridman, Jordan S., Minna, John D., Scherle, Peggy A.

“…We describe here the existence of a heregulin-HER3 autocrine loop, and the contribution of heregulin-dependent, HER2-mediated HER3 activation to gefitinib…”
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Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma by LEE, Amie Y, BIAO HE, LIANG YOU, DADFARMAY, Sina, ZHIDONG XU, MAZIERES, Julien, MIKAMI, Iwao, MCCORMICK, Frank, JABLONS, David M

“…Secreted frizzled-related proteins (sFRPs) comprise a family of five secreted glycoproteins that antagonize Wnt signaling. Aberrant activation and upregulation…”
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New technique to prevent prolonged air leak: use of ‘Tachosuture’ technique by Nishida, Tatsuya, Mikami, Iwao, Fujii, Yoshitaka

“…Prolonged air leak (defined as air leak >7 days), caused by pulmonary resection or alveolar-pleural fistula, increases postoperative morbidity, prolongs…”
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Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer by MAZIERES, Julien, BIAO HE, LIANG YOU, ZHIDONG XU, LEE, Amie Y, MIKAMI, Iwao, REGUART, Noemi, ROSELL, Rafael, MCCORMICK, Frank, JABLONS, David M

“…Aberrant activation of the Wingless-type (Wnt) signaling pathway is associated with a variety of human cancers, and we recently reported the importance of…”
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Down-regulation of SIX3 is associated with clinical outcome in lung adenocarcinoma by Mo, Min-Li, Okamoto, Junichi, Chen, Zhao, Hirata, Tomomi, Mikami, Iwao, Bosco-Clément, Geneviève, Li, Hui, Zhou, Hai-Meng, Jablons, David M, He, Biao

“…Lung cancer is a common cancer and the leading cause of cancer-related death worldwide. SIX3 is a human homologue of the highly conserved sine oculis gene…”
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An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth by LIANG YOU, BIAO HE, MCCORMICK, Frank, JABLONS, David M, ZHIDONG XU, UEMATSU, Kazutsugu, MAZIERES, Julien, FUJII, Naoaki, MIKAMI, Iwao, REGUART, Noemi, MCINTOSH, Joe K, KASHANI-SABET, Mohammed

“…Activation of the Wnt/beta-catenin signaling pathway has been associated with human cancers. To test whether Wnt-2 signal is a survival factor in human…”
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Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis by MAZIERES, Julien, LIANG YOU, BIAO HE, ZHIDONG XU, LEE, Amie Y, MIKAMI, Iwao, MCCORMICK, Frank, JABLONS, David M

“…The Wnt family of secreted glycoproteins is widely involved in cell proliferation, differentiation and oncogenesis. Many Wnt signaling genes are upregulated…”
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Wnt2 as a new therapeutic target in malignant pleural mesothelioma by Mazieres, Julien, You, Liang, He, Biao, Xu, Zhidong, Twogood, Sarah, Lee, Amie Y., Reguart, Noemi, Batra, Sonny, Mikami, Iwao, Jablons, David M.

“…Malignant mesothelioma of the pleura (MPM) is a highly aggressive neoplasm with a poor prognosis and limited treatment options. A better understanding of its…”
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Surgical treatment of metachronous nonsmall cell lung cancer by Haraguchi, Shuji, Koizumi, Kiyoshi, Hirata, Tomomi, Hirai, Kyoji, Mikami, Iwao, Kubokura, Hirotoshi, Nakajima, Yuki, Shimizu, Kazuo

“…We report surgical results of metachronous nonsmall cell lung cancer (NSCLC). We report mortality and analyze prognostic factors for overall survival in…”
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Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma by Okamoto, Junichi, Mikami, Iwao, Tominaga, Yuichi, Kuchenbecker, Kristopher M, Lin, Yu-Ching, Bravo, Dawn T, Clement, Genevieve, Yagui-Beltran, Adam, Ray, M Roshni, Koizumi, Kiyoshi, He, Biao, Jablons, David M

“…Heat shock protein 90 (Hsp90) is an abundant molecular chaperone that mediates the maturation and stability of a variety of proteins associated with the…”
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Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines by Lin, Yu-Ching, You, Liang, Xu, Zhidong, He, Biao, Mikami, Iwao, Thung, Elaine, Chou, Josephine, Kuchenbecker, Kristopher, Kim, Jae, Raz, Dan, Yang, Cheng-Ta, Chen, Jan-Kan, Jablons, David M.

“…Aberrant activation of Wingless-type (Wnt) signaling pathway plays a critical role in oncogenesis of various human cancers. Wnt inhibitory factor-1 (WIF-1) is…”
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Efficacy of Wnt-1 monoclonal antibody in sarcoma cells by Mikami, Iwao, You, Liang, He, Biao, Xu, Zhidong, Batra, Sonny, Lee, Amie Y, Mazieres, Julien, Reguart, Noemi, Uematsu, Kazutsugu, Koizumi, Kiyoshi, Jablons, David M

“…Sarcomas are one of the most refractory diseases among malignant tumors. More effective therapies based on an increased understanding of the molecular biology…”
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Staple Line Coverage with a Polyglycolic Acid Sheet Plus Pleural Abrasion by Thoracoscopic Surgery for Primary Spontaneous Pneumothorax in Young Patients by Haraguchi, Shuji, Koizumi, Kiyoshi, Mikami, Iwao, Okamoto, Junichi, Iijima, Yoshihito, Ibi, Takayuki, Shimizu, Kazuo

“…Purpose: We investigated surgical results of staple line coverage with a polyglycolic acid sheet plus pleural abrasion by thoracoscopic surgery for treating…”
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Prognostic Significance of the Tumor Suppressor Gene Maspin in Non–Small Cell Lung Cancer by Hirai, Kyoji, Koizumi, Kiyoshi, Haraguchi, Shuji, Hirata, Tomomi, Mikami, Iwao, Fukushima, Mitsuhiro, Yamagishi, Shigeki, Kawashima, Tetsuo, Okada, Daisuke, Shimizu, Kazuo, Kawamoto, Masashi

“…Maspin is a serpin protease inhibitor, which is known to suppress tumor progression in breast cancer and to be regulated by wild-type p53. This study was…”
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Surgical treatment of lung cancer combined with interstitial pneumonia: the effect of surgical approach on postoperative acute exacerbation by Koizumi, Kiyoshi, Hirata, Tomomi, Hirai, Kyoji, Mikami, Iwao, Okada, Daisuke, Yamagishi, Shigeki, Kawashima, Tetsuo, Nakajima, Yuki, Shimizu, Kazuo

“…Postoperative acute exacerbation of interstitial pneumonia (IP) is known to be a serious complication in the surgical treatment for primary lung cancer…”
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Surgical Results of Completion Pneumonectomy by Haraguchi, Shuji, Koizumi, Kiyoshi, Hirata, Tomomi, Hirai, Kyoji, Mikami, Iwao, Kubokura, Hirotoshi, Shimizu, Kazuo

“…Purpose: We report our experience with completion pneumonectomy (CP). Methods: We report on operative procedure and morbidity, mortality, and survival rates…”
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Diaphragmatic repair of two cases of hepatic hydrothorax using video-assisted thoracoscopic surgery by Ibi, Takayuki, Koizumi, Kiyoshi, Hirata, Tomomi, Mikami, Iwao, Hisayoshi, Takao, Shimizu, Kazuo

“…Hepatic hydrothorax is defined as the presence of a significant pleural effusion that develops in a patient with cirrhosis of the liver who does not have…”
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