Search Results - "Mikael C. I. Karlsson"

IL-18 in inflammatory and autoimmune disease by Sedimbi, Saikiran K., Hägglöf, Thomas, Karlsson, Mikael C. I.

“…Inflammation serves as the first line of defense in response to tissue injury, guiding the immune system to ensure preservation of the host. The inflammatory…”
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Identification of a receptor required for the anti-inflammatory activity of IVIG by Anthony, Robert M, Wermeling, Fredrik, Karlsson, Mikael C.I, Ravetch, Jeffrey V

“…The anti-inflammatory activity of intravenous Ig (IVIG) results from a minor population of the pooled IgG molecules that contains terminal α2,6-sialic acid…”
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Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase by Ravishankar, Buvana, Liu, Haiyun, Shinde, Rahul, Chandler, Phillip, Baban, Babak, Tanaka, Masato, Munn, David H, Mellor, Andrew L, Karlsson, Mikael C. I, McGaha, Tracy L

“…Tolerance to self-antigens present in apoptotic cells is critical to maintain immune-homeostasis and prevent systemic autoimmunity. However, mechanisms that…”
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Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen by McGaha, Tracy L., Chen, Yunying, Ravishankar, Buvana, van Rooijen, Nico, Karlsson, Mikael C.I.

“…Marginal zone macrophages (MZMs) are a small subset of specialized splenic macrophages known to interact with apoptotic material entering the spleen from…”
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Antigen-loaded exosomes alone induce Th1-type memory through a B cell–dependent mechanism by Qazi, Khaleda Rahman, Gehrmann, Ulf, Domange Jordö, Emilie, Karlsson, Mikael C.I., Gabrielsson, Susanne

“…Exosomes are nanovesicles harboring proteins important for antigen presentation. We compared the potency of differently loaded exosomes, directly loaded with…”
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Deficiency of mature B cells does not alter the atherogenic response to castration in male mice by Wilhelmson, Anna S., Johansson, Inger, Fogelstrand, Linda, Fagman, Johan Bourghardt, Arnal, Jean-Francois, Karlsson, Mikael C. I., Tivesten, Åsa

“…Testosterone deficiency in men is associated with increased atherosclerosis burden and increased cardiovascular risk. In male mice, testosterone deficiency…”
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The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype by Lundgren, Sebastian, Karnevi, Emelie, Elebro, Jacob, Nodin, Björn, Karlsson, Mikael C I, Eberhard, Jakob, Leandersson, Karin, Jirström, Karin

“…Dendritic cells (DC) and tumour-associated macrophages (TAM) are essential in linking the innate and adaptive immune response against tumour cells and tumour…”
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inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells by Enoksson, Sara Lind, Grasset, Emilie K, Hägglöf, Thomas, Mattsson, Nina, Kaiser, Ylva, Gabrielsson, Susanne, McGaha, Tracy L, Scheynius, Annika, Karlsson, Mikael C. I

“…Inflammatory responses initiate rapid production of IL-1 family cytokines, including IL-18. This cytokine is produced at high levels in inflammatory diseases,…”
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WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function by Westerberg, Lisa S., de la Fuente, Miguel A., Wermeling, Fredrik, Ochs, Hans D., Karlsson, Mikael C.I., Snapper, Scott B., Notarangelo, Luigi D.

“…Development of hematopoietic cells depends on a dynamic actin cytoskeleton. Here we demonstrate that expression of the cytoskeletal regulator WASP, mutated in…”
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A Novel B Cell-Mediated Transport of IgE-Immune Complexes to the Follicle of the Spleen by Hjelm, Fredrik, Karlsson, Mikael C. I, Heyman, Birgitta

“…Ag administered i.v. to mice along with specific IgE or IgG2a induces higher Ab- and CD4(+) T cell responses than Ag administered alone. The IgE effect is…”
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The role of B cells in immune cell activation in polycystic ovary syndrome by Ascani, Angelo, Torstensson, Sara, Risal, Sanjiv, Lu, Haojiang, Eriksson, Gustaw, Li, Congru, Teschl, Sabrina, Menezes, Joana, Sandor, Katalin, Ohlsson, Claes, Svensson, Camilla I, Karlsson, Mikael C I, Stradner, Martin Helmut, Obermayer-Pietsch, Barbara, Stener-Victorin, Elisabet

“…Variations in B cell numbers are associated with polycystic ovary syndrome (PCOS) through unknown mechanisms. Here, we demonstrate that B cells are not central…”
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Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma by van Hooren, Luuk, Vaccaro, Alessandra, Ramachandran, Mohanraj, Vazaios, Konstantinos, Libard, Sylwia, van de Walle, Tiarne, Georganaki, Maria, Huang, Hua, Pietilä, Ilkka, Lau, Joey, Ulvmar, Maria H., Karlsson, Mikael C. I., Zetterling, Maria, Mangsbo, Sara M., Jakola, Asgeir S., Olsson Bontell, Thomas, Smits, Anja, Essand, Magnus, Dimberg, Anna

“…Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical…”
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TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation by Fuxe, Jonas, Karlsson, Mikael C.I

“…Abstract Metastatic spread of tumor cells to vital organs is the major cause of death in cancer. Accumulating data support an important role of infiltrating…”
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Distinct developmental pathways from blood monocytes generate human lung macrophage diversity by Evren, Elza, Ringqvist, Emma, Tripathi, Kumar Parijat, Sleiers, Natalie, Rives, Inés Có, Alisjahbana, Arlisa, Gao, Yu, Sarhan, Dhifaf, Halle, Tor, Sorini, Chiara, Lepzien, Rico, Marquardt, Nicole, Michaëlsson, Jakob, Smed-Sörensen, Anna, Botling, Johan, Karlsson, Mikael C.I., Villablanca, Eduardo J., Willinger, Tim

“…The study of human macrophages and their ontogeny is an important unresolved issue. Here, we use a humanized mouse model expressing human cytokines to dissect…”
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Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant by Mattsson, Johan, Yrlid, Ulf, Stensson, Anneli, Schön, Karin, Karlsson, Mikael C I, Ravetch, Jeffrey V, Lycke, Nils Y

“…A detailed understanding of how activation of innate immunity can be exploited to generate more effective vaccines is critically required. However, little is…”
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regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses by Chen, Yunying, Wermeling, Fredrik, Sundqvist, Johanna, Jonsson, Ann-Beth, Tryggvason, Karl, Pikkarainen, Timo, Karlsson, Mikael C.I

“…Recognition of microbial components by TLR, key sensors of infection, leads to induction of inflammatory responses. We found that, in vivo, TLR4 engagement by…”
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The expression of BAFF, APRIL and TWEAK is altered in eczema skin but not in the circulation of atopic and seborrheic eczema patients by Chen, Yunying, Lind Enoksson, Sara, Johansson, Catharina, Karlsson, Maria A, Lundeberg, Lena, Nilsson, Gunnar, Scheynius, Annika, Karlsson, Mikael C I

“…The TNF family cytokines BAFF (B-cell activating factor of the TNF family) and APRIL (a proliferation-inducing ligand) are crucial survival factors for B-cell…”
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AIRE regulates T-cell-independent B-cell responses through BAFF by Lindh, Emma, Lind, Sara M, Lindmark, Evelina, Hässler, Signe, Perheentupa, Jaakko, Peltonen, Leena, Winqvist, Ola, Karlsson, Mikael C.I

“…Autoimmune polyendocrine syndrome type I (APS I) results in multiple endocrine organ destruction and is caused by mutations in the autoimmune regulator gene…”
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Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis by Georgoudaki, Anna-Maria, Prokopec, Kajsa E., Boura, Vanessa F., Hellqvist, Eva, Sohn, Silke, Östling, Jeanette, Dahan, Rony, Harris, Robert A., Rantalainen, Mattias, Klevebring, Daniel, Sund, Malin, Brage, Suzanne Egyhazi, Fuxe, Jonas, Rolny, Charlotte, Li, Fubin, Ravetch, Jeffrey V., Karlsson, Mikael C.I.

“…Tumors are composed of multiple cell types besides the tumor cells themselves, including innate immune cells such as macrophages. Tumor-associated macrophages…”
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BLyS-mediated modulation of naive B cell subsets impacts HIV Env-induced antibody responses by Dosenovic, Pia, Soldemo, Martina, Scholz, Jean L, O'Dell, Sijy, Grasset, Emilie K, Pelletier, Nadège, Karlsson, Mikael C I, Mascola, John R, Wyatt, Richard T, Cancro, Michael P, Karlsson Hedestam, Gunilla B

“…Neutralizing Abs provide the protective effect of the majority of existing human vaccines. For a prophylactic vaccine against HIV-1, broadly neutralizing Abs…”
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