Search Results - "Mijovic, C H"

Differential expression of HLA-DQ alleles in peripheral blood mononuclear cells: alleles associated with susceptibility to and protection from autoimmune type 1 diabetes by Britten, A. C., Mijovic, C. H., Barnett, A. H., Kelly, M. A.

“…Summary Differential expression of human leucocyte antigen (HLA) class II genes has been postulated to influence the risk of developing autoimmune disease. In…”
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Molecular aspects of type 1 diabetes by Kelly, M A, Rayner, M L, Mijovic, C H, Barnett, A H

“…Type 1 diabetes is a T cell mediated autoimmune disease, characterised by the selective destruction of pancreatic β cells, and susceptibility is determined by…”
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Genetic and immunological characteristics of Type I diabetes mellitus in an Indo-Aryan population by KELLY, M. A, ALVI, N. S, CROFT, N. J, MIJOVIC, C. H, BOTTAZZO, G. F, BARNETT, A. H

“…Our aim was to characterise the genetic and immunological features associated with Type I (insulin-dependent) diabetes mellitus in a cohort of Indo-Aryan…”
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Mitochondrial DNA A3243G mutation in patients with early- or late-onset type 2 diabetes mellitus in Hong Kong Chinese by Ng, M. C. Y., Yeung, V. T. F., Chow, C. C., Li, J. K. Y., Smith, P. R., Mijovic, C. H., Critchley, J. A. J. H., Barnett, A. H., Cockram, C. S., Chan, J. C. N.

“…BACKGROUND AND OBJECTIVES The mitochondrial DNA A to G mutation at nucleotide 3243 (mt3243) is associated with a subtype of diabetes characterized by maternal…”
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Human leucocyte antigen and insulin gene regions and nephropathy in Type I diabetes by CHOWDHURY, T. A, DYER, P. H, MIJOVIC, C. H, DUNGER, D. B, BARNETT, A. H, BAIN, S. C

“…Diabetic nephropathy seems to have a strong genetic component. Genes involved in the genetic susceptibility to Type I (insulin-dependent) diabetes have been…”
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Assessment of the non-HLA-DR-DQ contribution to IDDM1 in British Caucasian families: analysis of LMP7 polymorphisms by McTernan, C. L., Stewart, L. C., Mijovic, C. H., Barnett, A. H.

“…SUMMARY Aims  Whilst HLA‐DRB1 and HLA‐DQ alleles contribute to IDDM1, the major determinant of genetic susceptibility to Type 1 diabetes mellitus, other major…”
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HLA typing and immunological characterization of young-onset diabetes mellitus in a Hong Kong Chinese population by Kelly, M. A., Chan, J. C. N., Heward, J., Mijovic, C. H., Zimmet, P. Z., Yeung, V. T. F., Cockram, C., Barnett, A. H.

“…SUMMARY Aims  A study of the Hong Kong Chinese showed that the majority of subjects with young‐onset diabetes (age of diagnosis < 35 years) present with a…”
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Sequencing of the Second Exon of the MHC Class II DQ6 Alleles in Patients with Type 1 Diabetes by Rayner, M.L., Kelly, M.A., Mijovic, C.H., Barnett, A.H.

“…The MHC class II molecule DQ6 is strongly associated with protection from type 1 diabetes. A small number of diabetic subjects have been typed as positive for…”
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HLA alleles and IDDM in children in Hungary: a comparison with Finland by Hermann, R, Mijovic, C.H, Rayner, M, Croft, N, Kelly, M.A, Jenkins, D, Soltész, G, Barnett, A.H

“…It has been postulated that variation in the distribution of human leukocyte antigen (HLA)-encoded susceptibility alleles for insulin-dependent diabetes…”
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Long‐Term Expression of an HLA‐DQ Molecule in the EBV‐Transformed Bare Lymphocyte Cell Line, BLS‐1, using a Plasmid Vector by Kelly, M. A., Rayner, M. L., Mijovic, C. H., Barnett, A. H.

“…The HLA class II molecule, DQ6, confers strong natural protection against the development of type 1 diabetes. The mechanism of disease protection is unknown,…”
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Susceptibility to Type 1 (insulin-dependent) diabetes mellitus is determined by MHC class II molecules. What about DR4 ? by MIJOVIC, C. H, JENKINS, D, PENNY, M. A

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Susceptibility to IDDM in a Chinese population. Role of HLA class II alleles by Penny, M. A., Jenkins, D., Mijovic, C. H., Jacobs, K. H., Cavan, D. A., Yeung, V. T., Cockram, C. S., Hawkins, B. R., Fletcher, J. A., Barnett, A. H.

“…Susceptibility to IDDM in a Chinese population. Role of HLA class II alleles. M A Penny , D Jenkins , C H Mijovic , K H Jacobs , D A Cavan , V T Yeung , C S…”
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The mitochondrial tRNA[Leu(UUR)] A to G 3243 mutation is associated with insulin-dependent and non-insulin-dependent diabetes in a Chinese population by Smith, P R, Dronsfield, M J, Mijovic, C H, Hattersley, A T, Yeung, V T, Cockram, C, Chan, J C, Barnett, A H, Bain, S C

“…The mitochondrial DNA tRNA[Leu(UUR)] A to G 3243 mutation is associated with maternally inherited diabetes in Caucasians and Japanese. In a Hong Kong Chinese…”
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The Insulin Gene Region and Susceptibility to Insulin-Dependent Diabetes Mellitus in Four Races; New Insights from Afro-Caribbean Race-Specific Haplotypes by Mijovic, C. H., Penny, M. A., Jenkins, D., Jacobs, K., Heward, J., Knight, S. W., Lucassen, A., Morrison, E., Barnett, A. H.

“…The IDDM2 component of the genetic susceptibility to insulin-dependent diabetes mellitus (IDDM) has been mapped to chromosome 1 lpl5.5. The exact identity of…”
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Tumour necrosis factor-beta polymorphism in unlikely to determine susceptibility to type 1 (insulin-dependent) diabetes mellitus by JENKINS, D, PENNY, M. A, MIJOVIC, C. H, JACOBS, K. H, FLETCHER, J, BARNETT, A. H

“…Tumour necrosis factor gene polymorphism has been proposed as a determinant of Type 1 (insulin-dependent) diabetes mellitus. Tumour necrosis factor-beta gene…”
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The influence of HLA-DR and -DQ alleles on progression to multiple sclerosis following a clinically isolated syndrome by Kelly, M A, Cavan, D A, Penny, M A, Mijovic, C H, Jenkins, D, Morrissey, S, Miller, D H, Barnett, A H, Francis, D A

“…A 5-year follow-up study was performed on 70 Caucasian patients presenting with isolated neurological syndromes of the optic nerve, brain stem, or spinal cord…”
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HLA class II gene polymorphism contributes little to Hashimoto's thyroiditis by Jenkins, D, Penny, M A, Fletcher, J A, Jacobs, K H, Mijovic, C H, Franklyn, J A, Sheppard, M C

“…Previous studies of HLA and Hashimoto's thyroiditis have shown weak associations between the disease and various HLA-DR antigens. To define better the…”
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HLA-DQA1 and -DQB1 alleles associated with genetic susceptibility to IDDM in a black population by Mijovic, C. H., Jenkins, D., Jacobs, K. H., Penny, M. A., Fletcher, J. A., Barnett, A. H.

“…HLA-DQA1 and -DQB1 alleles associated with genetic susceptibility to IDDM in a black population. C H Mijovic , D Jenkins , K H Jacobs , M A Penny , J A…”
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Investigation of the mode of inheritance of insulin-dependent diabetes mellitus in Japanese subjects by JENKINS, D, PENNY, M. A, UCHIGATA, Y, JACOBS, K. H, MIJOVIC, C. H, HIRATA, Y, OTANI, T, FLETCHER, J, BRADWELL, A. R, BARNETT, A. H

“…Previous studies have shown that insulin-dependent diabetes mellitus is positively associated with HLA-DR4 and HLA-DR9 in Japanese populations. It was proposed…”
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DRB genotyping supports recessive inheritance of DR3-associated susceptibility to insulin-dependent diabetes mellitus by JENKINS, D, FLETCHER, J, PENNY, M. A, MIJOVIC, C. H, JACOBS, K. H, BRADWELL, A. R, BARNETT, A. H

“…The mode of inheritance of HLA-associated susceptibility to insulin-dependent diabetes mellitus was investigated by the antigen genotype frequency among…”
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