Search Results - "Mijovic, C"

Differential expression of HLA-DQ alleles in peripheral blood mononuclear cells: alleles associated with susceptibility to and protection from autoimmune type 1 diabetes by Britten, A. C., Mijovic, C. H., Barnett, A. H., Kelly, M. A.

“…Summary Differential expression of human leucocyte antigen (HLA) class II genes has been postulated to influence the risk of developing autoimmune disease. In…”
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Molecular aspects of type 1 diabetes by Kelly, M A, Rayner, M L, Mijovic, C H, Barnett, A H

“…Type 1 diabetes is a T cell mediated autoimmune disease, characterised by the selective destruction of pancreatic β cells, and susceptibility is determined by…”
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Genetic and immunological characteristics of Type I diabetes mellitus in an Indo-Aryan population by KELLY, M. A, ALVI, N. S, CROFT, N. J, MIJOVIC, C. H, BOTTAZZO, G. F, BARNETT, A. H

“…Our aim was to characterise the genetic and immunological features associated with Type I (insulin-dependent) diabetes mellitus in a cohort of Indo-Aryan…”
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Mitochondrial DNA A3243G mutation in patients with early- or late-onset type 2 diabetes mellitus in Hong Kong Chinese by Ng, M. C. Y., Yeung, V. T. F., Chow, C. C., Li, J. K. Y., Smith, P. R., Mijovic, C. H., Critchley, J. A. J. H., Barnett, A. H., Cockram, C. S., Chan, J. C. N.

“…BACKGROUND AND OBJECTIVES The mitochondrial DNA A to G mutation at nucleotide 3243 (mt3243) is associated with a subtype of diabetes characterized by maternal…”
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Lack of association between polymorphism of the thyrotropin receptor gene and Graves' disease in United Kingdom and Hong Kong Chinese patients: case control and family-based studies by Allahabadia, A, Heward, J M, Mijovic, C, Carr-Smith, J, Daykin, J, Cockram, C, Barnett, A H, Sheppard, M C, Franklyn, J A, Gough, S C

“…The thyrotropin receptor (TSH-R) gene is a candidate for genetic susceptibility to Graves' disease (GD). Previous case control studies investigating allelic…”
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Human leucocyte antigen and insulin gene regions and nephropathy in Type I diabetes by CHOWDHURY, T. A, DYER, P. H, MIJOVIC, C. H, DUNGER, D. B, BARNETT, A. H, BAIN, S. C

“…Diabetic nephropathy seems to have a strong genetic component. Genes involved in the genetic susceptibility to Type I (insulin-dependent) diabetes have been…”
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Assessment of the non-HLA-DR-DQ contribution to IDDM1 in British Caucasian families: analysis of LMP7 polymorphisms by McTernan, C. L., Stewart, L. C., Mijovic, C. H., Barnett, A. H.

“…SUMMARY Aims  Whilst HLA‐DRB1 and HLA‐DQ alleles contribute to IDDM1, the major determinant of genetic susceptibility to Type 1 diabetes mellitus, other major…”
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Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping by Todd, J. A, Mijovic, C, Fletcher, J, Jenkins, D, Bradwell, A. R, Barnett, A. H

“…INSULIN-dependent (type I) diabetes mellitus (IDDM) follows an autoimmune destruction of the insulin-producing beta-cells of the pancreas. Family and…”
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Sequencing of the Second Exon of the MHC Class II DQ6 Alleles in Patients with Type 1 Diabetes by Rayner, M.L., Kelly, M.A., Mijovic, C.H., Barnett, A.H.

“…The MHC class II molecule DQ6 is strongly associated with protection from type 1 diabetes. A small number of diabetic subjects have been typed as positive for…”
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HLA typing and immunological characterization of young-onset diabetes mellitus in a Hong Kong Chinese population by Kelly, M. A., Chan, J. C. N., Heward, J., Mijovic, C. H., Zimmet, P. Z., Yeung, V. T. F., Cockram, C., Barnett, A. H.

“…SUMMARY Aims  A study of the Hong Kong Chinese showed that the majority of subjects with young‐onset diabetes (age of diagnosis < 35 years) present with a…”
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HLA alleles and IDDM in children in Hungary: a comparison with Finland by Hermann, R, Mijovic, C.H, Rayner, M, Croft, N, Kelly, M.A, Jenkins, D, Soltész, G, Barnett, A.H

“…It has been postulated that variation in the distribution of human leukocyte antigen (HLA)-encoded susceptibility alleles for insulin-dependent diabetes…”
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Long‐Term Expression of an HLA‐DQ Molecule in the EBV‐Transformed Bare Lymphocyte Cell Line, BLS‐1, using a Plasmid Vector by Kelly, M. A., Rayner, M. L., Mijovic, C. H., Barnett, A. H.

“…The HLA class II molecule, DQ6, confers strong natural protection against the development of type 1 diabetes. The mechanism of disease protection is unknown,…”
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The mitochondrial tRNA[Leu(UUR)] A to G 3243 mutation is associated with insulin-dependent and non-insulin-dependent diabetes in a Chinese population by Smith, P R, Dronsfield, M J, Mijovic, C H, Hattersley, A T, Yeung, V T, Cockram, C, Chan, J C, Barnett, A H, Bain, S C

“…The mitochondrial DNA tRNA[Leu(UUR)] A to G 3243 mutation is associated with maternally inherited diabetes in Caucasians and Japanese. In a Hong Kong Chinese…”
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Susceptibility to IDDM in a Chinese population. Role of HLA class II alleles by Penny, M. A., Jenkins, D., Mijovic, C. H., Jacobs, K. H., Cavan, D. A., Yeung, V. T., Cockram, C. S., Hawkins, B. R., Fletcher, J. A., Barnett, A. H.

“…Susceptibility to IDDM in a Chinese population. Role of HLA class II alleles. M A Penny , D Jenkins , C H Mijovic , K H Jacobs , D A Cavan , V T Yeung , C S…”
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Susceptibility to Type 1 (insulin-dependent) diabetes mellitus is determined by MHC class II molecules. What about DR4 ? by MIJOVIC, C. H, JENKINS, D, PENNY, M. A

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HLA-DQA1 and -DQB1 alleles associated with genetic susceptibility to IDDM in a black population by MIJOVIC, C. H, JENKINS, D, JACOBS, K. H, PENNY, M. A, FLETCHER, J. A, BARNETT, A. H

“…Transracial analysis provides a method of distinguishing primary associations between insulin-dependent diabetes mellitus (IDDM) and HLA class II alleles from…”
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The HLA association with Graves' disease is sex-specific in Hong Kong Chinese subjects by Cavan, D A, Penny, M A, Jacobs, K H, Kelly, M A, Jenkins, D, Mijovic, C, Chow, C, Cockram, C S, Hawkins, B R, Barnett, A H

“…Graves' disease is associated with different HLA genes in Caucasians and the Chinese, in whom the HLA associations may be stronger in males than females…”
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Susceptibility to IDDM in a Chinese population : role of HLA class II alleles by PENNY, M. A, JENKINS, D, MIJOVIC, C. H, JACOBS, K. H, CAVAN, D. A, YEUNG, V. T. F, COCKRAM, C. S, HAWKINS, B. R, FLETCHER, J. A, BARNETT, A. H

“…MHC associations with IDDM in a Chinese population were studied to investigate genetic susceptibility to the disorder. The frequency of HLA-DR3 was…”
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The Insulin Gene Region and Susceptibility to Insulin-Dependent Diabetes Mellitus in Four Races; New Insights from Afro-Caribbean Race-Specific Haplotypes by Mijovic, C. H., Penny, M. A., Jenkins, D., Jacobs, K., Heward, J., Knight, S. W., Lucassen, A., Morrison, E., Barnett, A. H.

“…The IDDM2 component of the genetic susceptibility to insulin-dependent diabetes mellitus (IDDM) has been mapped to chromosome 1 lpl5.5. The exact identity of…”
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Identification of susceptibility loci for type 1 (insulin-dependent) diabetes by trans-racial gene mapping by JENKINS, D, MIJOVIC, C, FLETCHER, J, JACOBS, K. H, BRADWELL, A. R, BARNETT, A. H

“…A major component of inherited susceptibility to Type 1 (insulin-dependent) diabetes mellitus has been mapped to the major histocompatibility complex. Certain…”
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