Search Results - "Mihic, Anton"

The effect of cyclic stretch on maturation and 3D tissue formation of human embryonic stem cell-derived cardiomyocytes by Mihic, Anton, Li, Jiao, Miyagi, Yasuo, Gagliardi, Mark, Li, Shu-Hong, Zu, Jean, Weisel, Richard D, Keller, Gordon, Li, Ren-Ke

“…Abstract The goal of cardiac tissue engineering is to restore function to the damaged myocardium with regenerative constructs. Human embryonic stem…”
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Generation of the epicardial lineage from human pluripotent stem cells by Witty, Alec D, Mihic, Anton, Tam, Roger Y, Fisher, Stephanie A, Mikryukov, Alexander, Shoichet, Molly S, Li, Ren-Ke, Kattman, Steven J, Keller, Gordon

“…The ability to generate epicardial cells from human pluripotent stem cells will facilitate studies of heart regeneration. The epicardium supports cardiomyocyte…”
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Role of miR-145 in cardiac myofibroblast differentiation by Wang, Yao-Sheng, Li, Shu-Hong, Guo, Jian, Mihic, Anton, Wu, Jun, Sun, Lu, Davis, Kelly, Weisel, Richard D, Li, Ren-Ke

“…Abstract Following a myocardial infarction (MI), fibroblasts differentiate to myofibroblasts, which possess some of the characteristics of smooth muscle cells…”
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Canopy 2 attenuates the transition from compensatory hypertrophy to dilated heart failure in hypertrophic cardiomyopathy by Guo, Jian, Mihic, Anton, Wu, Jun, Zhang, Yuemei, Singh, Kaustabh, Dhingra, Sanjiv, Weisel, Richard D, Li, Ren-Ke

“…A mismatch between adequate angiogenesis and overgrowth of myocytes may be a critical mechanism controlling the transition from adaptive hypertrophy to heart…”
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Preserving Prostaglandin E2 Level Prevents Rejection of Implanted Allogeneic Mesenchymal Stem Cells and Restores Postinfarction Ventricular Function by Dhingra, Sanjiv, Li, Peng, Huang, Xi-Ping, Guo, Jian, Wu, Jun, Mihic, Anton, Li, Shu-Hong, Zang, Wang-Fu, Shen, Daniel, Weisel, Richard D., Singal, Pawan K., Li, Ren-Ke

“…BACKGROUND—Allogeneic mesenchymal stem cells (MSCs) were immunoprivileged early after cardiac implantation and improved heart function in preclinical and…”
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A secreted protein (Canopy 2, CNPY2) enhances angiogenesis and promotes smooth muscle cell migration and proliferation by Guo, Jian, Zhang, Yuemei, Mihic, Anton, Li, Shu-Hong, Sun, Zhuo, Shao, Zhengbo, Wu, Jun, Weisel, Richard D, Li, Ren-Ke

“…Ischaemic heart disease is a leading cause of mortality. After ischaemic injury, tissue hypoxia induces the activity of angiogenic factors that promote…”
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Trafficking defect and proteasomal degradation contribute to the phenotype of a novel KCNH2 long QT syndrome mutation by Mihic, Anton, Chauhan, Vijay S, Gao, Xiaodong, Oudit, Gavin Y, Tsushima, Robert G

“…The Kv11.1 (hERG) K+ channel plays a fundamental role in cardiac repolarization. Missense mutations in KCNH2, the gene encoding Kv11.1, cause long QT syndrome…”
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Modulation of Alloimmune Responses by Interleukin-10 Prevents Rejection of Implanted Allogeneic Smooth Muscle Cells and Restores Postinfarction Ventricular Function by Dhingra, Sanjiv, Wu, Jun, Li, Shu-Hong, Guo, Jian, Huang, Xi-Ping, Mihic, Anton, Hu, Jim, Weisel, Richard D, Li, Ren-Ke

“…Interleukin-10 (IL-10) gene transduction into allogeneic smooth muscle cells (SMCs) was evaluated to improve the long-term benefits of allogeneic cell…”
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A Conductive Polymer Hydrogel Supports Cell Electrical Signaling and Improves Cardiac Function After Implantation into Myocardial Infarct by Mihic, Anton, Cui, Zhi, Wu, Jun, Vlacic, Goran, Miyagi, Yasuo, Li, Shu-Hong, Lu, Sun, Sung, Hsing-Wen, Weisel, Richard D, Li, Ren-Ke

“…Efficient cardiac function requires synchronous ventricular contraction. After myocardial infarction, the nonconductive nature of scar tissue contributes to…”
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VEGF-loaded microsphere patch for local protein delivery to the ischemic heart by Rodness, Jonathan, Mihic, Anton, Miyagi, Yasuo, Wu, Jun, Weisel, Richard D., Li, Ren-Ke

“…[Display omitted] Background: Revascularization of the heart after myocardial infarction (MI) using growth factors delivered by hydrogel-based microspheres…”
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Inhibition of Cholesterol Biosynthesis Impairs Insulin Secretion and Voltage-Gated Calcium Channel Function in Pancreatic β-Cells by Xia, Fuzhen, Xie, Li, Mihic, Anton, Gao, Xiaodong, Chen, Yi, Gaisano, Herbert Y, Tsushima, Robert G

“…Insulin secretion from pancreatic β-cells is mediated by the opening of voltage-gated Ca2+ channels (CaV) and exocytosis of insulin dense core vesicles…”
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Serum-free differentiation of functional human coronary-like vascular smooth muscle cells from embryonic stem cells by El-Mounayri, Omar, Mihic, Anton, Shikatani, Eric A, Gagliardi, Mark, Steinbach, Sarah K, Dubois, Nicole, Dacosta, Ralph, Li, Ren-Ke, Keller, Gordon, Husain, Mansoor

“…Despite the diverse developmental origins of vascular smooth muscle cells (VSMCs), recent attempts to generate VSMCs from human embryonic stem cells (hESCs)…”
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Role of WNT/β-Catenin Signaling in Rejuvenating Myogenic Differentiation of Aged Mesenchymal Stem Cells from Cardiac Patients by Brunt, Keith R, Zhang, Yuemei, Mihic, Anton, Li, Mingxi, Li, Shu-Hong, Xue, Phil, Zhang, William, Basmaji, Samir, Tsang, Katherine, Weisel, Richard D, Yau, Terrence M, Li, Ren-Ke

“…Autologous stem cell therapy has not been as effective as forecasted from preclinical studies. Patient age was reported as an important contributing factor…”
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Surgical ventricular restoration with a cell- and cytokine-seeded biodegradable scaffold by Miyagi, Yasuo, Zeng, Faquan, Huang, Xi-Ping, Foltz, Warren D, Wu, Jun, Mihic, Anton, Yau, Terrence M, Weisel, Richard D, Li, Ren-Ke

“…Abstract Late after a myocardial infarction (MI), surgical ventricular restoration (SVR) can reduce left ventricular volumes, but an enhanced cardiac patch may…”
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Abstract 15288: Conductive Polymer Hydrogel for Enhancement of Electrical Propagation in Border Zone Myocardium after Myocardial Infarction by Mihic, Anton, Miyagi, Yasuo, Wu, Jun, Vlacic, Goran, Lam, Martin, Cui, Zui, Li, Shu-hong, Sun, Lu, Weisel, Richard D, Li, Ren-Ke

“…Abstract only Introduction: After myocardial infarction (MI), cardiomyocyte death results in a non-contractile fibrotic scar and altered electrical properties,…”
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Abstract 18248: Reduced β-catenin Expression in Mouse Cardiomyocytes Increases Matrix Metalloproteinase Activation and Apoptosis, Producing Greater Post-Infarction Ventricular Dysfunction by Singh, Kaustabh, Mihic, Anton, Hatta, Kota, Amini-Nik, Saeid, Wu, Jun, Li, Shu-Hong, Sun, Lu, Alman, Benjamin A, Brunt, Keith R, Weisel, Richard D, Li, Ren-Ke

“…Abstract only Introduction: The loss of beating cardiomyocytes after myocardial infarction (MI) is followed by detrimental remodelling involving activation of…”
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SNARE protein regulation of cardiac potassium channels and atrial natriuretic factor secretion by Chao, Christin C.T, Mihic, Anton, Tsushima, Robert G, Gaisano, Herbert Y

“…Abstract Coordinated cardiac ion channel gating is fundamental for generation of action potential and excitability throughout the myocardium. The interaction…”
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Binding of Syntaxin 1A to the C-terminus of hERG Channels Affects Channel Trafficking and Inactivation by Mihic, Anton, Gao, Xiaodong, Shrier, Alvin, Gaisano, Herbert, Tsushima, Robert

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Abstract P013: Canopy 2 Encodes for a Novel Secreted Proangiogenic Factor that Revascularizes and Regenerates Murine Hearts Post Myocardial Infarction by Guo, Jian, Sun, Zhuo, Mihic, Anton, Au, Sharon, Li, Shu Hong, Hatta, Kota, Zhang, Yue Mei, Dhingra, Sanjiv, Wu, Jun, Weisel, Richard D, Li, Ren-Ke

“…Abstract only Through genomic screening of 256 novel genes by RT-PCR in human smooth muscle cells, we discovered that Canopy 2 (CNPY2), previously named as…”
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Interaction of hERG channels and syntaxin 1A by Mihic, Anton

“…The human ether-à-go-go related gene (hERG) encodes the pore-forming voltage-gated K+ channel that is essential for cardiac repolarization. Dr. Tsushima’s…”
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