Search Results - "Mihara, Katsuyoshi"

Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling by Otera, Hidenori, Miyata, Non, Kuge, Osamu, Mihara, Katsuyoshi

“…Mitochondrial fission facilitates cytochrome c release from the intracristae space into the cytoplasm during intrinsic apoptosis, although how the…”
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Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin by Ban, Tadato, Ishihara, Takaya, Kohno, Hiroto, Saita, Shotaro, Ichimura, Ayaka, Maenaka, Katsumi, Oka, Toshihiko, Mihara, Katsuyoshi, Ishihara, Naotada

“…Ban et al.  show that optic atrophy 1 (OPA1) and cardiolipin mediate mitochondrial fusion. In contrast, a homotypic trans -OPA1 interaction independent of…”
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Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts by Song, Moshi, Mihara, Katsuyoshi, Chen, Yun, Scorrano, Luca, Dorn, Gerald W.

“…How mitochondrial dynamism (fission and fusion) affects mitochondrial quality control is unclear. We uncovered distinct effects on mitophagy of inhibiting…”
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Regulation of mitochondrial morphology through proteolytic cleavage of OPA1 by Ishihara, Naotada, Fujita, Yuu, Oka, Toshihiko, Mihara, Katsuyoshi

“…The dynamin‐like GTPase OPA1, a causal gene product of human dominant optic atrophy, functions in mitochondrial fusion and inner membrane remodeling. It has…”
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Mitotic Phosphorylation of Dynamin-related GTPase Drp1 Participates in Mitochondrial Fission by Taguchi, Naoko, Ishihara, Naotada, Jofuku, Akihiro, Oka, Toshihiko, Mihara, Katsuyoshi

“…Organelles are inherited to daughter cells beyond dynamic changes of the membrane structure during mitosis. Mitochondria are dynamic entities, frequently…”
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Molecular mechanisms and physiologic functions of mitochondrial dynamics by Otera, Hidenori, Mihara, Katsuyoshi

“…Mitochondria are highly dynamic organelles that continuously change their shape through frequent fusion, fission and movement throughout the cell, and these…”
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Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics by Schmitt, Karen, Grimm, Amandine, Dallmann, Robert, Oettinghaus, Bjoern, Restelli, Lisa Michelle, Witzig, Melissa, Ishihara, Naotada, Mihara, Katsuyoshi, Ripperger, Jürgen A., Albrecht, Urs, Frank, Stephan, Brown, Steven A., Eckert, Anne

“…Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative phosphorylation and generation of ATP, are strongly…”
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Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Against Energy Stress by Ikeda, Yoshiyuki, Shirakabe, Akihiro, Maejima, Yasuhiro, Zhai, Peiyong, Sciarretta, Sebastiano, Toli, Jessica, Nomura, Masatoshi, Mihara, Katsuyoshi, Egashira, Kensuke, Ohishi, Mitsuru, Abdellatif, Maha, Sadoshima, Junichi

“…RATIONALE:Both fusion and fission contribute to mitochondrial quality control. How unopposed fusion affects survival of cardiomyocytes and left ventricular…”
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Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells by Otera, Hidenori, Wang, Chunxin, Cleland, Megan M, Setoguchi, Kiyoko, Yokota, Sadaki, Youle, Richard J, Mihara, Katsuyoshi

“…The cytoplasmic dynamin-related guanosine triphosphatase Drp1 is recruited to mitochondria and mediates mitochondrial fission. Although the mitochondrial outer…”
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MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity by Hanada, Yuki, Ishihara, Naotada, Wang, Lixiang, Otera, Hidenori, Ishihara, Takaya, Koshiba, Takumi, Mihara, Katsuyoshi, Ogawa, Yoshihiro, Nomura, Masatoshi

“…Mitochondria are multifunctional organelles that produce energy and are critical for various signaling pathways. Mitochondrial antiviral signaling (MAVS) is a…”
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Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c by Ban-Ishihara, Reiko, Ishihara, Takaya, Sasaki, Narie, Mihara, Katsuyoshi, Ishihara, Naotada

“…Mammalian cells typically contain thousands of copies of mitochondrial DNA assembled into hundreds of nucleoids. Here we analyzed the dynamic features of…”
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Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity by Ishihara, Naotada, Eura, Yuka, Mihara, Katsuyoshi

“…The mammalian homologues of yeast and Drosophila Fzo, mitofusin (Mfn) 1 and 2, are both essential for mitochondrial fusion and maintenance of mitochondrial…”
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PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria by Okatsu, Kei, Oka, Toshihiko, Iguchi, Masahiro, Imamura, Kenji, Kosako, Hidetaka, Tani, Naoki, Kimura, Mayumi, Go, Etsu, Koyano, Fumika, Funayama, Manabu, Shiba-Fukushima, Kahori, Sato, Shigeto, Shimizu, Hideaki, Fukunaga, Yuko, Taniguchi, Hisaaki, Komatsu, Masaaki, Hattori, Nobutaka, Mihara, Katsuyoshi, Tanaka, Keiji, Matsuda, Noriyuki

“…Dysfunction of PINK1, a mitochondrial Ser/Thr kinase, causes familial Parkinson's disease (PD). Recent studies have revealed that PINK1 is rapidly degraded in…”
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Dynamics of Mitochondrial DNA Nucleoids Regulated by Mitochondrial Fission Is Essential for Maintenance of Homogeneously Active Mitochondria during Neonatal Heart Development by Ishihara, Takaya, Ban-Ishihara, Reiko, Maeda, Maki, Matsunaga, Yui, Ichimura, Ayaka, Kyogoku, Sachiko, Aoki, Hiroki, Katada, Shun, Nakada, Kazuto, Nomura, Masatoshi, Mizushima, Noboru, Mihara, Katsuyoshi, Ishihara, Naotada

“…Mitochondria are dynamic organelles, and their fusion and fission regulate cellular signaling, development, and mitochondrial homeostasis, including…”
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Regulation and physiologic functions of GTPases in mitochondrial fusion and fission in mammals by Ishihara, Naotada, Otera, Hidenori, Oka, Toshihiko, Mihara, Katsuyoshi

“…Mitochondria are double membrane-bound organelles with tubular network structures that are essential for oxidative ATP production and play pivotal roles in…”
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Mitochondrial Dynamics: Functional Link with Apoptosis by Otera, Hidenori, Mihara, Katsuyoshi

“…Mitochondria participate in a variety of physiologic processes, such as ATP production, lipid metabolism, iron-sulfur cluster biogenesis, and calcium…”
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Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice by Morinaga, Hidetaka, Kato, Hiroki, Otera, Hidenori, Nomura, Masatoshi, Maeda, Maki, Mihara, Katsuyoshi, Taguchi, Naoko, Goto, Yu-ichi, Nonaka, Ikuya, Suzuki, Satoshi O, Masuda, Keiji, Jofuku, Akihiro, Ishihara, Naotada, Takayanagi, Ryoichi, Yokota, Sadaki, Nakanishi, Yae

“…Mitochondrial morphology is dynamically controlled by a balance between fusion and fission. The physiological importance of mitochondrial fission in…”
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Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration by Wang, Lixiang, Ishihara, Takaya, Ibayashi, Yuta, Tatsushima, Keita, Setoyama, Daiki, Hanada, Yuki, Takeichi, Yukina, Sakamoto, Shohei, Yokota, Sadaki, Mihara, Katsuyoshi, Kang, Dongchon, Ishihara, Naotada, Takayanagi, Ryoichi, Nomura, Masatoshi

“…Aim/hypothesis Mitochondria and the endoplasmic reticulum (ER) physically interact by close structural juxtaposition, via the mitochondria-associated ER…”
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Mitochondrial Fission Factor Drp1 Maintains Oocyte Quality via Dynamic Rearrangement of Multiple Organelles by Udagawa, Osamu, Ishihara, Takaya, Maeda, Maki, Matsunaga, Yui, Tsukamoto, Satoshi, Kawano, Natsuko, Miyado, Kenji, Shitara, Hiroshi, Yokota, Sadaki, Nomura, Masatoshi, Mihara, Katsuyoshi, Mizushima, Noboru, Ishihara, Naotada

“…Mitochondria are dynamic organelles that change their morphology by active fusion and fission in response to cellular signaling and differentiation [1, 2]. The…”
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Cytosolic factor- and TOM-independent import of C-tail-anchored mitochondrial outer membrane proteins by Setoguchi, Kiyoko, Otera, Hidenori, Mihara, Katsuyoshi

“…C‐tail‐anchored (C‐TA) proteins are anchored to specific organelle membranes by a single transmembrane segment (TMS) at the C‐terminus, extruding the…”
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