Search Results - "Mihaly, G W"

Pharmacokinetics of primaquine in man: identification of the carboxylic acid derivative as a major plasma metabolite by Mihaly, GW, Ward, SA, Edwards, G, Orme, ML, Breckenridge, AM

“…A method is described for the simultaneous determination of the carboxylic acid and N‐acetyl‐derivatives of primaquine, in plasma and urine. After oral…”
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Differences in the binding of quinine and quinidine to plasma proteins by Mihaly, GW, Ching, MS, Klejn, MB, Paull, J, Smallwood, RA

“…1. Little is known about the comparative plasma protein binding of the antimalarial agents quinine (QN) and its isomer quinidine (QD). We have examined the in…”
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Pharmacokinetics of primaquine in man. I. Studies of the absolute bioavailability and effects of dose size by Mihaly, GW, Ward, SA, Edwards, G, Nicholl, DD, Orme, ML, Breckenridge, AM

“…The pharmacokinetics of primaquine have been examined in five healthy volunteers who received single oral doses of 15, 30 and 45 mg of the drug, on separate…”
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Omeprazole: a study of its inhibition of gastric pH and oral pharmacokinetics after morning or evening dosage by Prichard, P J, Yeomans, N D, Mihaly, G W, Jones, D B, Buckle, P J, Smallwood, R A, Louis, W J

“…Pharmacodynamic and pharmacokinetic studies of omeprazole, a new gastric antisecretory agent, were undertaken in 8 healthy subjects. The drug was administered…”
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Oxygen dependence of omeprazole clearance and sulfone and sulfide metabolite formation in the isolated perfused rat liver by Angus, P W, Mihaly, G W, Morgan, D J, Smallwood, R A

“…Severe acute hypoxia is known to inhibit markedly the elimination of oxidatively metabolized drugs by the isolated liver. However, little is known of the…”
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Discrimination between the venous equilibrium and sinusoidal models of hepatic drug elimination in the isolated perfused rat liver by perturbation of propranolol protein binding by Jones, D B, Morgan, D J, Mihaly, G W, Webster, L K, Smallwood, R A

“…To discriminate between two widely used models of hepatic drug elimination, the venous equilibrium and sinusoidal models, we examined the effect of altering…”
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Placental drug transfer: effects of gestational age and species by Mihaly, G W, Morgan, D J

“…The available evidence suggests that for most drugs, adverse effects in the fetus may vary with gestational state and among species due to: (i) changes in the…”
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Ontogeny of fetal renal organic cation excretion: a study with cimetidine and ranitidine during the latter half of gestation in the pregnant ewe by Czuba, M A, Morgan, D J, Ching, M S, Mihaly, G W, Hardy, K J, Smallwood, R A

“…The organic cation cimetidine undergoes renal tubular secretion in the near-term ovine fetus. We investigated the ontogeny of renal tubular secretion of…”
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Low clearance of cimetidine across the human placenta by Ching, M S, Mihaly, G W, Morgan, D J, Date, N M, Hardy, K J, Smallwood, R A

“…The transfer of cimetidine across the isolated perfused human placenta was examined. Placentas obtained at cesarean section were perfused for 2 hr from both…”
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Intracellular binding is an important determinant of the avid hepatic uptake of the high clearance drug omeprazole by Sewell, R B, Brook, C W, Mihaly, G W, Morgan, D J, Smallwood, R A

“…The contribution of intracellular storage to hepatic uptake of the high clearance drug, omeprazole, was examined in the recirculating isolated perfused rat…”
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Hypoxia impairs conjugation and elimination of harmol in the isolated perfused rat liver by Angus, P W, Mihaly, G W, Morgan, D J, Smallwood, R A

“…Although studies in isolated hepatocytes have demonstrated that hypoxia adversely affects drug conjugation, the impact of hypoxia on drug elimination by…”
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Mechanism of triamterene transfer across the human placenta by Ching, M S, Czuba, M A, Mihaly, G W, Morgan, D J, Hyman, K M, Paull, J D, Smallwood, R A

“…The diuretic, triamterene, had been regarded to be a drug which was actively transported by the placenta from fetus to mother. In the present study, the…”
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Malaria infection impairs glucuronidation and biliary excretion by the isolated perfused rat liver by Murdoch, R T, Ghabrial, H, Mihaly, G W, Morgan, D J, Smallwood, R A

“…1. The effect of the erythrocyte stage of malaria infection on hepatic glucuronidation, biliary excretion and oxidation processes was investigated using…”
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Oral bioavailability of omeprazole before and after chronic therapy in patients with duodenal ulcer by Ching, MS, Mihaly, GW, Angus, PW, Morgan, DJ, Devenish‐Meares, S., Yeomans, ND, Smallwood, RA

“…1. This study investigated the mechanism of the increase in oral bioavailability of omeprazole during repeated oral dosing. Eight patients with duodenal ulcer…”
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Placental transfer and renal elimination of cimetidine in maternal and fetal sheep by Mihaly, G W, Jones, D B, Morgan, D J, Ching, M S, Webster, L K, Smallwood, R A, Hardy, K J

“…The placental transfer and renal elimination of cimetidine were studied at steady state in near-term pregnant sheep. In seven nonanesthetized sheep, maternal…”
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The disposition of primaquine in the isolated perfused rat liver. Effect of dose size by Ward, S A, Mihaly, G W, Nicholl, D D, Edwards, G, Breckenridge, A M

“…The disposition of 14C-radiolabeled primaquine in the isolated perfused rat liver preparation was investigated after the administration of 0.5-, 1.5-, and…”
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Effects of gestational age on the disposition of propranolol in pregnant sheep by Czuba, M A, Mihaly, G W, Ching, M S, Morgan, D J, Hardy, K J, Smallwood, R A

“…Maternal and fetal disposition of the beta adrenoceptor blocking drug, propranolol was examined in the pregnant sheep from day 95 to day 140 (term, 145 days)…”
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High-performance liquid chromatographic analysis of amodiaquine in human plasma by Mihaly, G W, Nicholl, D D, Edwards, G, Ward, S A, Orme, M L, Warrell, D A, Breckenridge, A M

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Oxygen dependence of salbutamol elimination by the isolated perfused rat liver by Angus, P W, Mihaly, G W, Morgan, D J, Smallwood, R A

“…Although impairment of drug metabolism by severe hypoxia is well documented in perfused liver preparations, the degree of hypoxia required to produce…”
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High-performance liquid chromatographic method for the determination of pyrimethamine and its 3-N-oxide metabolite in biological fluids by Coleman, M D, Edwards, G, Mihaly, G W, Howells, R E, Breckenridge, A M

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