Search Results - "Mihaila, Silvia M."

Kidney-based in vitro models for drug-induced toxicity testing by Faria, João, Ahmed, Sabbir, Gerritsen, Karin G. F., Mihaila, Silvia M., Masereeuw, Rosalinde

“…The kidney is frequently involved in adverse effects caused by exposure to foreign compounds, including drugs. An early prediction of those effects is crucial…”
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Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells by Gaharwar, Akhilesh K., Mihaila, Silvia M., Swami, Archana, Patel, Alpesh, Sant, Shilpa, Reis, Rui L., Marques, Alexandra P., Gomes, Manuela E., Khademhosseini, Ali

“…Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are…”
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Organs-on-chip technology: a tool to tackle genetic kidney diseases by G. Valverde, Marta, Faria, João, Sendino Garví, Elena, Janssen, Manoe J., Masereeuw, Rosalinde, Mihăilă, Silvia M.

“…Chronic kidney disease (CKD) is a major healthcare burden that takes a toll on the quality of life of many patients. Emerging evidence indicates that a…”
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Photocrosslinkable Kappa-Carrageenan Hydrogels for Tissue Engineering Applications by Mihaila, Silvia M., Gaharwar, Akhilesh K., Reis, Rui L., Marques, Alexandra P., Gomes, Manuela E., Khademhosseini, Ali

“…Kappa carrageenan (κ‐CA) is a natural‐origin polymer that closely mimics the glycosaminoglycan structure, one of the most important constituents of native…”
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Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion by Mihaila, Silvia M, Faria, João, Stefens, Maurice F J, Stamatialis, Dimitrios, Verhaar, Marianne C, Gerritsen, Karin G F, Masereeuw, Rosalinde

“…In chronic kidney disease (CKD), the secretion of uremic toxins is compromised leading to their accumulation in blood, which contributes to uremic…”
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The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule: An Integrated Computational and In Vitro Study by King, Jasia, Mihaila, Silvia M, Ahmed, Sabbir, Truckenmüller, Roman, Giselbrecht, Stefan, Masereeuw, Rosalinde, Carlier, Aurélie

“…Research has shown that traditional dialysis is an insufficient long-term therapy for patients suffering from end-stage kidney disease due to the high…”
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Synthetic Extracellular Matrices with Nonlinear Elasticity Regulate Cellular Organization by Liu, Kaizheng, Mihaila, Silvia M, Rowan, Alan, Oosterwijk, Egbert, Kouwer, Paul H. J

“…One of the promises of synthetic materials in cell culturing is that control over their molecular structures may ultimately be used to control their biological…”
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Introduction of Specific 3D Micromorphologies in Collagen Scaffolds Using Odd and Even Dicarboxylic Acids by Pot, Michiel W, Mihaila, Silvia M, te Brinke, Dana, van der Borg, Guus, Oosterwijk, Egbert, Daamen, Willeke F, van Kuppevelt, Toin H

“…The construction of scaffolds and subsequent incorporation of cells and biologics have been widely investigated to regenerate damaged tissues. Scaffolds act as…”
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Highly elastomeric poly(glycerol sebacate)- co -poly(ethylene glycol) amphiphilic block copolymers by Patel, Alpesh, Gaharwar, Akhilesh K, Iviglia, Giorgio, Zhang, Hongbin, Mukundan, Shilpaa, Mihaila, Silvia M, Demarchi, Danilo, Khademhosseini, Ali

“…Abstract Poly(glycerol sebacate) (PGS), a tough elastomer, has been proposed for tissue engineering applications due to its desired mechanical properties,…”
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Blueprints of Architected Materials: A Guide to Metamaterial Design for Tissue Engineering by Kalogeropoulou, Maria, Kracher, Anna, Fucile, Pierpaolo, Mihăilă, Silvia M, Moroni, Lorenzo

“…Mechanical metamaterials are rationally designed structures engineered to exhibit extraordinary properties, often surpassing those of their constituent…”
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The osteogenic differentiation of SSEA-4 sub-population of human adipose derived stem cells using silicate nanoplatelets by Mihaila, Silvia M, Gaharwar, Akhilesh K, Reis, Rui L, Khademhosseini, Ali, Marques, Alexandra P, Gomes, Manuela E

“…Abstract How to surpass in vitro stem cell differentiation, reducing cell manipulation, and lead the in situ regeneration process after transplantation,…”
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Nanoclay-enriched poly(ɛ-caprolactone) electrospun scaffolds for osteogenic differentiation of human mesenchymal stem cells by Gaharwar, Akhilesh K, Mukundan, Shilpaa, Karaca, Elif, Dolatshahi-Pirouz, Alireza, Patel, Alpesh, Rangarajan, Kaushik, Mihaila, Silvia M, Iviglia, Giorgio, Zhang, Hongbin, Khademhosseini, Ali

“…Musculoskeletal tissue engineering aims at repairing and regenerating damaged tissues using biological tissue substitutes. One approach to achieve this aim is…”
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Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells by Gaharwar, Akhilesh K., Mihaila, Silvia M., Swami, Archana, Patel, Alpesh, Sant, Shilpa, Reis, Rui L., Marques, Alexandra P., Gomes, Manuela E., Khademhosseini, Ali

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Hyperbranched Polyester Hydrogels with Controlled Drug Release and Cell Adhesion Properties by Zhang, Hongbin, Patel, Alpesh, Gaharwar, Akhilesh K, Mihaila, Silvia M, Iviglia, Giorgio, Mukundan, Shilpaa, Bae, Hojae, Yang, Huai, Khademhosseini, Ali

“…Hyperbranched polyesters (HPE) have a high efficiency to encapsulate bioactive agents, including drugs, genes, and proteins, due to their globe-like…”
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Portable, wearable and implantable artificial kidney systems: needs, opportunities and challenges by Ramada, David Loureiro, de Vries, Joost, Vollenbroek, Jeroen, Noor, Nazia, ter Beek, Odyl, Mihăilă, Silvia M., Wieringa, Fokko, Masereeuw, Rosalinde, Gerritsen, Karin, Stamatialis, Dimitrios

“…Haemodialysis is life sustaining but expensive, provides limited removal of uraemic solutes, is associated with poor patient quality of life and has a large…”
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Synthetic Extracellular Matrices as a Toolbox to Tune Stem Cell Secretome by Liu, Kaizheng, Veenendaal, Tomas, Wiendels, Maury, Ruiz-Zapata, Alejandra M, van Laar, Justin, Kyranas, Rafail, Enting, Hilde, van Cranenbroek, Bram, Koenen, Hans J. P. M, Mihaila, Silvia M, Oosterwijk, Egbert, Kouwer, Paul H. J

“…The application of stem cell-derived secretome in regenerative therapies offers the key advantage that instead of the stem cells, only their effective…”
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Diabetic proximal tubulopathy: Can we mimic the disease for in vitro screening of SGLT inhibitors? by Faria, João, Gerritsen, Karin G.F., Nguyen, Tri Q., Mihaila, Silvia M., Masereeuw, Rosalinde

“…Diabetic kidney disease (DKD) is the foremost cause of renal failure. While the glomeruli are severely affected in the course of the disease, the main…”
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Role of extracellular matrix components and structure in new renal models in vitro by Lacueva-Aparicio, Alodia, Lindoso, Rafael Soares, Mihăilă, Silvia M, Giménez, Ignacio

“…The extracellular matrix (ECM), a complex set of fibrillar proteins and proteoglycans, supports the renal parenchyma and provides biomechanical and biochemical…”
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Bioengineered Kidney Tubules Efficiently Clear Uremic Toxins in Experimental Dialysis Conditions by Faria, João, Ahmed, Sabbir, Stamatialis, Dimitrios, Verhaar, Marianne C, Masereeuw, Rosalinde, Gerritsen, Karin G F, Mihăilă, Silvia M

“…Patients with end-stage kidney disease (ESKD) suffer from high levels of protein-bound uremic toxins (PBUTs) that contribute to various comorbidities…”
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Mesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury by Faria, João, Calcat-I-Cervera, Sandra, Skovronova, Renata, Broeksma, Bonnie C, Berends, Alinda J, Zaal, Esther A, Bussolati, Benedetta, O'Brien, Timothy, Mihăilă, Silvia M, Masereeuw, Rosalinde

“…Ischemia/reperfusion injury is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the…”
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