Search Results - "Miguez, Andres"

Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation by Comella-Bolla, Andrea, Orlandi, Javier G., Miguez, Andrés, Straccia, Marco, García-Bravo, María, Bombau, Georgina, Galofré, Mireia, Sanders, Phil, Carrere, Jordi, Segovia, José Carlos, Blasi, Joan, Allen, Nicholas D., Alberch, Jordi, Soriano, Jordi, Canals, Josep M.

“…Human pluripotent stem cells (hPSCs) are a powerful tool for modelling human development. In recent years, hPSCs have become central in cell-based therapies…”
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Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease by Miguez, Andrés, Gomis, Cinta, Vila, Cristina, Monguió-Tortajada, Marta, Fernández-García, Sara, Bombau, Georgina, Galofré, Mireia, García-Bravo, María, Sanders, Phil, Fernández-Medina, Helena, Poquet, Blanca, Salado-Manzano, Cristina, Roura, Santiago, Alberch, Jordi, Segovia, José Carlos, Allen, Nicholas D., Borràs, Francesc E., Canals, Josep M.

“…Huntington's disease (HD) is an incurable inherited brain disorder characterised by massive degeneration of striatal neurons, which correlates with abnormal…”
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Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease by Fernández-Nogales, Marta, Hernández, Félix, Miguez, Andrés, Alberch, Jordi, Ginés, Silvia, Pérez-Navarro, Esther, Lucas, José J

“…Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by brain atrophy particularly in striatum leading to personality changes,…”
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CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease by Comella Bolla, Andrea, Valente, Tony, Miguez, Andres, Brito, Veronica, Gines, Silvia, Solà, Carme, Straccia, Marco, Canals, Josep M

“…In Huntington's disease (HD), striatal medium spiny neurons (MSNs) are particularly sensitive to the presence of a CAG repeat in the huntingtin (HTT) gene…”
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Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons by Martín-Ibáñez, Raquel, Pardo, Mónica, Giralt, Albert, Miguez, Andrés, Guardia, Inés, Marion-Poll, Lucile, Herranz, Cristina, Esgleas, Miriam, Garcia-Díaz Barriga, Gerardo, Edel, Michael J, Vicario-Abejón, Carlos, Alberch, Jordi, Girault, Jean-Antoine, Chan, Susan, Kastner, Philippe, Canals, Josep M

“…Here, we unravel the mechanism of action of the Ikaros family zinc finger protein Helios (He) during the development of striatal medium spiny neurons (MSNs)…”
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Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning by Miguez, Andrés, Ducret, Sébastien, Di Meglio, Thomas, Parras, Carlos, Hmidan, Hatem, Haton, Céline, Sekizar, Sowmya, Mannioui, Abdelkrim, Vidal, Marie, Kerever, Aurélien, Nyabi, Omar, Haigh, Jody, Zalc, Bernard, Rijli, Filippo M, Thomas, Jean-Léon

“…Oligodendrocytes are the myelin-forming cells of the vertebrate CNS. Little is known about the molecular control of region-specific oligodendrocyte…”
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Genetic tracing of subpopulation neurons in the prethalamus of mice (Mus musculus) by Delaunay, Delphine, Heydon, Katharina, Miguez, Andres, Schwab, Markus, Nave, Klaus-Armin, Thomas, Jean Leon, Spassky, Nathalie, Martinez, Salvador, Zalc, Bernard

“…Genetic labeling based on the Cre/lox reporter system has allowed the creation of fate maps for progenitor cells and their offspring. In the diencephalon,…”
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Reduced Fractalkine Levels Lead to Striatal Synaptic Plasticity Deficits in Huntington’s Disease by Kim, Anya, García-García, Esther, Straccia, Marco, Comella-Bolla, Andrea, Miguez, Andrés, Masana, Mercè, Alberch, Jordi, Canals, Josep M., Rodríguez, Manuel J.

“…Huntington’s disease (HD) is an inherited neurodegenerative disorder in which the striatum is the most affected brain region. Although a chronic inflammatory…”
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Early Downregulation of p75NTR by Genetic and Pharmacological Approaches Delays the Onset of Motor Deficits and Striatal Dysfunction in Huntington’s Disease Mice by Suelves, Nuria, Miguez, Andrés, López-Benito, Saray, Barriga, Gerardo García-Díaz, Giralt, Albert, Alvarez-Periel, Elena, Arévalo, Juan Carlos, Alberch, Jordi, Ginés, Silvia, Brito, Verónica

“…Deficits in striatal brain-derived neurotrophic factor (BDNF) delivery and/or BDNF/tropomyosin receptor kinase B (TrkB) signaling may contribute to…”
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Clusterin deficiency is associated with a lack of response to teriflunomide in multiple sclerosis by Malhotra, Sunny, Fissolo, Nicolas, Rodríguez‐Rivera, Carmen, Monreal, Enric, Montpeyo, Marta, Urcelay, Elena, Triviño, Juan Carlos, Pérez‐García, María José, Segura, Miguel F., Pappolla, Agustín, Río, Jordi, Vilaseca, Andreu, Fernández Velasco, José Ignacio, Miguez, Andrés, Goicoechea, Carlos, Martinez‐Vicente, Marta, Villar, Luisa M, Montalban, Xavier, Comabella, Manuel

“…Noteworthy, the expression pattern of CLU isoforms detected in non-responders after treatment was more prominent at 12 months since it was not observed at…”
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Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non‐cell‐autonomous neuronal damage by Matute‐Blanch, Clara, Brito, Verónica, Midaglia, Luciana, Villar, Luisa M, Garcia‐Diaz Barriga, Gerardo, Guzman de la Fuente, Alerie, Borrás, Eva, Fernández‐García, Sara, Calvo‐Barreiro, Laura, Miguez, Andrés, Costa‐Frossard, Lucienne, Pinteac, Rucsanda, Sabidó, Eduard, Alberch, Jordi, Fitzgerald, Denise C., Montalban, Xavier, Comabella, Manuel

“…Astrocytes became reactive upon high inflammatory CSF exposure (Figure 1B) and induced morphological alterations typically observed in neurodegenerative…”
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Structural Requirement of TAG-1 for Retinal Ganglion Cell Axons and Myelin in the Mouse Optic Nerve by Chatzopoulou, Elli, Miguez, Andres, Savvaki, Maria, Levasseur, Gregoire, Muzerelle, Aude, Muriel, Marie-Paule, Goureau, Olivier, Watanabe, Kazutada, Goutebroze, Laurence, Gaspar, Patricia, Zalc, Bernard, Karagogeos, Domna, Thomas, Jean-Leon

“…White matter axons organize into fascicles that grow over long distances and traverse very diverse environments. The molecular mechanisms preserving this…”
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B15 Human ipsc-mouse chimeras to study huntington’s disease phenotypes by Canals, Josep M, Miguez, Andres, Sanders, Phil, Bombau, Georgina, Vila, Cristina

“…Huntington’s disease (HD) is a hereditary neurodegenerative disorder mainly characterized by striatal atrophy and degeneration of medium spiny neurons (MSNs)…”
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Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis by Calvo, Charles-Félix, Fontaine, Romain H, Soueid, Jihane, Tammela, Tuomas, Makinen, Taija, Alfaro-Cervello, Clara, Bonnaud, Fabien, Miguez, Andres, Benhaim, Lucile, Xu, Yunling, Barallobre, Maria-José, Moutkine, Imane, Lyytikkä, Johannes, Tatlisumak, Turgut, Pytowski, Bronislaw, Zalc, Bernard, Richardson, William, Kessaris, Nicoletta, Garcia-Verdugo, Jose Manuel, Alitalo, Kari, Eichmann, Anne, Thomas, Jean-Léon

“…Neural stem cells (NSCs) are slowly dividing astrocytes that are intimately associated with capillary endothelial cells in the subventricular zone (SVZ) of the…”
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Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75 NTR up-regulation and astrocyte-mediated inflammation by Miguez, Andrés, García-Díaz Barriga, Gerardo, Brito, Verónica, Straccia, Marco, Giralt, Albert, Ginés, Silvia, Canals, Josep M., Alberch, Jordi

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Early Downregulation of p75 NTR by Genetic and Pharmacological Approaches Delays the Onset of Motor Deficits and Striatal Dysfunction in Huntington's Disease Mice by Suelves, Nuria, Miguez, Andrés, López-Benito, Saray, Barriga, Gerardo García-Díaz, Giralt, Albert, Alvarez-Periel, Elena, Arévalo, Juan Carlos, Alberch, Jordi, Ginés, Silvia, Brito, Verónica

“…Deficits in striatal brain-derived neurotrophic factor (BDNF) delivery and/or BDNF/tropomyosin receptor kinase B (TrkB) signaling may contribute to…”
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Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation by Miguez, Andrés, García-Díaz Barriga, Gerardo, Brito, Verónica, Straccia, Marco, Giralt, Albert, Ginés, Silvia, Canals, Josep M, Alberch, Jordi

“…Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by motor and cognitive impairments, involving striatum, cortex and…”
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