Search Results - "Miguel Redondo, Juan"

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses by Baixauli, Francesc, Acín-Pérez, Rebeca, Villarroya-Beltrí, Carolina, Mazzeo, Carla, Nuñez-Andrade, Norman, Gabandé-Rodriguez, Enrique, Ledesma, Maria Dolores, Blázquez, Alberto, Martin, Miguel Angel, Falcón-Pérez, Juan Manuel, Redondo, Juan Miguel, Enríquez, Jose Antonio, Mittelbrunn, Maria

“…The endolysosomal system is critical for the maintenance of cellular homeostasis. However, how endolysosomal compartment is regulated by mitochondrial function…”
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Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects by Robles‐Vera, Iñaki, Toral, Marta, Visitación, Néstor, Sánchez, Manuel, Gómez‐Guzmán, Manuel, Muñoz, Raquel, Algieri, Francesca, Vezza, Teresa, Jiménez, Rosario, Gálvez, Julio, Romero, Miguel, Redondo, Juan Miguel, Duarte, Juan

“…Background and Purpose Hypertension is associated with gut dysbiosis. Here we have evaluated the effects of the angiotensin receptor antagonist losartan on gut…”
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The NO signalling pathway in aortic aneurysm and dissection by Toral, Marta, Fuente‐Alonso, Andrea, Campanero, Miguel R., Redondo, Juan Miguel

“…Recent studies have shown that NO is a central mediator in diseases associated with thoracic aortic aneurysm, such as Marfan syndrome. The progressive dilation…”
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Cux1 and Cux2 Regulate Dendritic Branching, Spine Morphology, and Synapses of the Upper Layer Neurons of the Cortex by Cubelos, Beatriz, Sebastián-Serrano, Alvaro, Beccari, Leonardo, Calcagnotto, Maria Elisa, Cisneros, Elsa, Kim, Seonhee, Dopazo, Ana, Alvarez-Dolado, Manuel, Redondo, Juan Miguel, Bovolenta, Paola, Walsh, Christopher A., Nieto, Marta

“…Dendrite branching and spine formation determines the function of morphologically distinct and specialized neuronal subclasses. However, little is known about…”
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Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis by MacGrogan, Donal, D’Amato, Gaetano, Travisano, Stanislao, Martinez-Poveda, Beatriz, Luxán, Guillermo, del Monte-Nieto, Gonzalo, Papoutsi, Tania, Sbroggio, Mauro, Bou, Vanesa, Gomez-del Arco, Pablo, Gómez, Manuel Jose, Zhou, Bin, Redondo, Juan Miguel, Jiménez-Borreguero, Luis J, de la Pompa, José Luis

“…RATIONALE:The Notch signaling pathway is crucial for primitive cardiac valve formation by epithelial–mesenchymal transition, and NOTCH1 mutations cause…”
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Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO by de la Fuente-Alonso, Andrea, Toral, Marta, Alfayate, Alvaro, Ruiz-Rodríguez, María Jesús, Bonzón-Kulichenko, Elena, Teixido-Tura, Gisela, Martínez-Martínez, Sara, Méndez-Olivares, María José, López-Maderuelo, Dolores, González-Valdés, Ileana, Garcia-Izquierdo, Eusebio, Mingo, Susana, Martín, Carlos E., Muiño-Mosquera, Laura, De Backer, Julie, Nistal, J. Francisco, Forteza, Alberto, Evangelista, Arturo, Vázquez, Jesús, Campanero, Miguel R., Redondo, Juan Miguel

“…Thoracic aortic aneurysm, as occurs in Marfan syndrome, is generally asymptomatic until dissection or rupture, requiring surgical intervention as the only…”
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p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation by González-Terán, Bárbara, López, Juan Antonio, Rodríguez, Elena, Leiva, Luis, Martínez-Martínez, Sara, Bernal, Juan Antonio, Jiménez-Borreguero, Luis Jesús, Redondo, Juan Miguel, Vazquez, Jesús, Sabio, Guadalupe

“…Disrupted organ growth leads to disease development. Hypertrophy underlies postnatal heart growth and is triggered after stress, but the molecular mechanisms…”
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CDCA7 is a critical mediator of lymphomagenesis that selectively regulates anchorage-independent growth by Jiménez-P, Raúl, Martín-Cortázar, Carla, Kourani, Omar, Chiodo, Yuri, Cordoba, Raul, Domínguez-Franjo, María Purificación, Redondo, Juan Miguel, Iglesias, Teresa, Campanero, Miguel R

“…Tumor formation involves the acquisition of numerous capacities along the progression from a normal cell into a malignant cell, including limitless…”
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NFATc3 controls tumour growth by regulating proliferation and migration of human astroglioma cells by Urso, Katia, Fernández, Andrés, Velasco, Patricia, Cotrina, Javier, de Andrés, Belén, Sánchez-Gómez, Pilar, Hernández-Laín, Aurelio, Hortelano, Sonsoles, Redondo, Juan Miguel, Cano, Eva

“…Calcium/Calcineurin/Nuclear Factor of Activated T cells (Ca/CN/NFAT) signalling pathway is the main calcium (Ca 2+ ) dependent signalling pathway involved in…”
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Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis by de Cárcer, Guillermo, Wachowicz, Paulina, Martínez-Martínez, Sara, Oller, Jorge, Méndez-Barbero, Nerea, Escobar, Beatriz, González-Loyola, Alejandra, Takaki, Tohru, El Bakkali, Aicha, Cámara, Juan A, Jiménez-Borreguero, Luis J, Bustelo, Xosé R, Cañamero, Marta, Mulero, Francisca, de los Ángeles Sevilla, María, Montero, María Jose, Redondo, Juan Miguel, Malumbres, Marcos

“…The kinase Plk1 has been studied primarily as a mitotic regulator in dividing cells, but de Cárcer et al . find that Plk1 deficiency or inhibition in mice…”
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Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles by Sreenivasan, Krishnamoorthy, Ianni, Alessandro, Künne, Carsten, Strilic, Boris, Günther, Stefan, Perdiguero, Eusebio, Krüger, Marcus, Spuler, Simone, Offermanns, Stefan, Gómez-del Arco, Pablo, Redondo, Juan Miguel, Munoz-Canoves, Pura, Kim, Johnny, Braun, Thomas

“…Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive,…”
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Deficiency of MMP17/MT4-MMP Proteolytic Activity Predisposes to Aortic Aneurysm in Mice by Martín-Alonso, Mara, García-Redondo, Ana B, Guo, Dongchuan, Camafeita, Emilio, Martínez, Fernando, Alfranca, Arántzazu, Méndez-Barbero, Nerea, Pollán, Ángela, Sánchez-Camacho, Cristina, Denhardt, David T, Seiki, Motoharu, Vázquez, Jesús, Salaices, Mercedes, Redondo, Juan Miguel, Milewicz, Dianna, Arroyo, Alicia G

“…RATIONALE:Aortic dissection or rupture resulting from aneurysm causes 1% to 2% of deaths in developed countries. These disorders are associated with mutations…”
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Cardiomyocyte calcineurin is required for the onset and progression of cardiac hypertrophy and fibrosis in adult mice by Martínez‐Martínez, Sara, Lozano‐Vidal, Noelia, López‐Maderuelo, María Dolores, Jiménez‐Borreguero, Luis J., Armesilla, Ángel Luis, Redondo, Juan Miguel

“…Previous studies have demonstrated that activation of calcineurin induces pathological cardiac hypertrophy (CH). In these studies, loss‐of‐function was mostly…”
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The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis by Gómez-del Arco, Pablo, Perdiguero, Eusebio, Yunes-Leites, Paula Sofia, Acín-Pérez, Rebeca, Zeini, Miriam, Garcia-Gomez, Antonio, Sreenivasan, Krishnamoorthy, Jiménez-Alcázar, Miguel, Segalés, Jessica, López-Maderuelo, Dolores, Ornés, Beatriz, Jiménez-Borreguero, Luis Jesús, D’Amato, Gaetano, Enshell-Seijffers, David, Morgan, Bruce, Georgopoulos, Katia, Islam, Abul B.M.M.K., Braun, Thomas, de la Pompa, José Luis, Kim, Johnny, Enriquez, José A., Ballestar, Esteban, Muñoz-Cánoves, Pura, Redondo, Juan Miguel

“…Heart muscle maintains blood circulation, while skeletal muscle powers skeletal movement. Despite having similar myofibrilar sarcomeric structures, these…”
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Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture by Villahoz, Silvia, Yunes-Leites, Paula Sofía, Méndez-Barbero, Nerea, Urso, Katia, Bonzon-Kulichenko, Elena, Ortega, Sagrario, Nistal, J. Francisco, Vazquez, Jesus, Offermanns, Stefan, Redondo, Juan Miguel, Campanero, Miguel R.

“…Aortic intramural hematoma (IMH) can evolve toward reabsorption, dissection or aneurysm. Hypertension is the most common predisposing factor in IMH and…”
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Defective p27 phosphorylation at serine 10 affects vascular reactivity and increases abdominal aortic aneurysm development via Cox-2 activation by Molina-Sánchez, Pedro, Del Campo, Lara, Esteban, Vanesa, Rius, Cristina, Chèvre, Raphael, Fuster, José J., Ferrer, Mercedes, Redondo, Juan Miguel, Andrés, Vicente

“…Phosphorylation at serine 10 (S10) is the major posttranslational modification of the tumor suppressor p27, and is reduced in both human and mouse…”
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Prostanoids in tumor angiogenesis: therapeutic intervention beyond COX-2 by Salvado, M. Dolores, Alfranca, Arántzazu, Haeggström, Jesper Z, Redondo, Juan Miguel

“…Prostanoids regulate angiogenesis in carcinoma and chronic inflammatory disease progression. Although prostanoid biosynthetic enzymes and signaling have been…”
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Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38 by Escolano, Amelia, Martínez-Martínez, Sara, Alfranca, Arántzazu, Urso, Katia, Izquierdo, Helena M, Delgado, Mario, Martín, Francisco, Sabio, Guadalupe, Sancho, David, Gómez-del Arco, Pablo, Redondo, Juan Miguel

“…Macrophages contribute to tissue homeostasis and influence inflammatory responses by modulating their phenotype in response to the local environment…”
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Regulator of calcineurin 1 mediates pathological vascular wall remodeling by Esteban, Vanesa, Méndez-Barbero, Nerea, Jiménez-Borreguero, Luis Jesús, Roqué, Mercè, Novensá, Laura, García-Redondo, Ana Belén, Salaices, Mercedes, Vila, Luis, Arbonés, María L, Campanero, Miguel R, Redondo, Juan Miguel

“…Artery wall remodeling, a major feature of diseases such as hypertension, restenosis, atherosclerosis, and aneurysm, involves changes in the tunica media mass…”
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Cooperative Synergy between NFAT and MyoD Regulates Myogenin Expression and Myogenesis by Armand, Anne-Sophie, Bourajjaj, Meriem, Martínez-Martínez, Sara, Azzouzi, Hamid el, da Costa Martins, Paula A., Hatzis, Pantelis, Seidler, Tim, Redondo, Juan Miguel, De Windt, Leon J.

“…Calcineurin/NFAT signaling is involved in multiple aspects of skeletal muscle development and disease. The myogenic basic helix-loop-helix transcription…”
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