Search Results - "Miguel, Ricardo Nunez"

A mutation in helicase motif IV of herpes simplex virus type 1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to the predicted helicase structure by Biswas, Subhajit, Miguel, Ricardo Nunez, Sukla, Soumi, Field, Hugh J

“…1 Department of Veterinary Medicine, University of Cambridge, Cambridge, UK 2 Department of Biochemistry, University of Cambridge, Cambridge, UK Correspondence…”
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Cryo-electron microscopy structures of human thyroid peroxidase (TPO) in complex with TPO antibodies by Baker, Stuart, Miguel, Ricardo Núñez, Thomas, Daniel, Powell, Michael, Furmaniak, Jadwiga, Smith, Bernard Rees

“…Determination of the structure of the extracellular domain of human thyroid peroxidase (hTPO) by cryo-electron microscopy (cryo-EM) is described. TPO, purified…”
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Functional Specificity of the Xenopus T-Domain Protein Brachyury Is Conferred by Its Ability to Interact with Smad1 by Messenger, Nigel J., Kabitschke, Christin, Andrews, Robert, Grimmer, Donna, Miguel, Ricardo Núñez, Blundell, Tom L., Smith, James C., Wardle, Fiona C.

“…Members of the T-box gene family play important and diverse roles in development and disease. Here, we study the functional specificities of the Xenopus…”
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Sequence patterns derived from the automated prediction of functional residues in structurally-aligned homologous protein families by NUNEZ MIGUEL, Ricardo

“…Motivation: Most proteins have evolved to perform specific functions that are dependent on the adoption of well-defined three-dimensional (3D) structures…”
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Distinct Features of Cap Binding by eIF4E1b Proteins by Kubacka, Dorota, Miguel, Ricardo Núñez, Minshall, Nicola, Darzynkiewicz, Edward, Standart, Nancy, Zuberek, Joanna

“…eIF4E1b, closely related to the canonical translation initiation factor 4E (eIF4E1a), cap-binding protein is highly expressed in mouse, Xenopus and zebrafish…”
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Structure of full-length TSH receptor in complex with antibody K1-70 by Núñez Miguel, Ricardo, Sanders, Paul, Allen, Lloyd, Evans, Michele, Holly, Matthew, Johnson, William, Sullivan, Andrew, Sanders, Jane, Furmaniak, Jadwiga, Rees Smith, Bernard

“…Determination of the full-length thyroid-stimulating hormone receptor (TSHR) structure by cryo-electron microscopy (cryo-EM) is described. The TSHR complexed…”
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Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei by Koumandou, V Lila, Klute, Mary J, Herman, Emily K, Nunez-Miguel, Ricardo, Dacks, Joel B, Field, Mark C

“…Intracellular trafficking and protein sorting are mediated by various protein complexes, with the retromer complex being primarily involved in retrograde…”
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Crystal structure of the TSH receptor (TSHR) bound to a blocking-type TSHR autoantibody by Sanders, Paul, Young, Stuart, Sanders, Jane, Kabelis, Katarzyna, Baker, Stuart, Sullivan, Andrew, Evans, Michele, Clark, Jill, Wilmot, Jane, Hu, Xiaoling, Roberts, Emma, Powell, Michael, Núñez Miguel, Ricardo, Furmaniak, Jadwiga, Rees Smith, Bernard

“…A complex of the TSH receptor extracellular domain (amino acids 22–260; TSHR260) bound to a blocking-type human monoclonal autoantibody (K1-70) was purified,…”
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Glycosylation pattern analysis of glycoprotein hormones and their receptors by Núñez Miguel, Ricardo, Sanders, Jane, Furmaniak, Jadwiga, Rees Smith, Bernard

“…We have studied glycosylation patterns in glycoprotein hormones (GPHs) and glycoprotein hormone receptor (GPHR) extracellular domains (ECD) from different…”
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A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins by Núñez Miguel, Ricardo, Wong, Joyce, Westoll, Julian F, Brooks, Heather J, O'Neill, Luke A J, Gay, Nicholas J, Bryant, Clare E, Monie, Tom P

“…The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the surface of immune system cells. TLR4 is activated by exposure to…”
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Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody by Sanders, Jane, Chirgadze, Dimitri Y, Sanders, Paul, Baker, Stuart, Sullivan, Andrew, Bhardwaja, Anshu, Bolton, Jane, Reeve, Magnus, Nakatake, Nobuhiro, Evans, Michele, Richards, Tonya, Powell, Michael, Miguel, Ricardo Núñez, Blundell, Tom L, Furmaniak, Jadwiga, Smith, Bernard Rees

“…To analyze interactions between the thyroid-stimulating hormone receptor (TSHR) and a thyroid-stimulating human monoclonal autoantibody (M22) at the molecular…”
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Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions by Bavro, Vassiliy N, Miguel, Ricardo Núñez, Schaedler, Theresia A, Robinson, Carol V, Zhou, Min, Barrera, Nelson P, van Veen, Hendrik W, Venter, Henrietta, Seeger, Markus A, Tate, Christopher G, Isaacson, Shoshanna C, Walmsley, Adrian R, Welch, Alex, Korkhov, Vladimir M

“…We describe a general mass spectrometry approach to determine subunit stoichiometry and lipid binding in intact membrane protein complexes. By exploring…”
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Structure and activation of the TSH receptor transmembrane domain by Núñez Miguel, Ricardo, Sanders, Jane, Furmaniak, Jadwiga, Smith, Bernard Rees

“…The thyroid-stimulating hormone receptor (TSHR) is the target autoantigen for TSHR-stimulating autoantibodies in Graves' disease. The TSHR is composed of: a…”
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Crystal structure of a ligand-free stable TSH receptor leucine-rich repeat domain by Miller-Gallacher, Jennifer, Sanders, Paul, Young, Stuart, Sullivan, Andrew, Baker, Stuart, Reddington, Samuel C, Clue, Matthew, Kabelis, Katarzyna, Clark, Jill, Wilmot, Jane, Thomas, Daniel, Chlebowska, Monika, Cole, Francesca, Pearson, Emily, Roberts, Emma, Holly, Matthew, Evans, Michele, Núñez Miguel, Ricardo, Powell, Michael, Sanders, Jane, Furmaniak, Jadwiga, Rees Smith, Bernard

“…The crystal structures of the thyroid-stimulating hormone receptor (TSHR) leucine-rich repeat domain (amino acids 22–260; TSHR260) in complex with a…”
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Allosteric mutants show that PrfA activation is dispensable for vacuole escape but required for efficient spread and Listeria survival in vivo by Deshayes, Caroline, Bielecka, Magdalena K., Cain, Robert J., Scortti, Mariela, de las Heras, Aitor, Pietras, Zbigniew, Luisi, Ben F., Núñez Miguel, Ricardo, Vázquez-Boland, José A.

“…Summary The transcriptional regulator PrfA controls key virulence determinants of the facultative intracellular pathogen Listeria monocytogenes. PrfA‐dependent…”
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Similarities and differences in interactions of thyroid stimulating and blocking autoantibodies with the TSH receptor by Núñez Miguel, Ricardo, Sanders, Jane, Sanders, Paul, Young, Stuart, Clark, Jill, Kabelis, Katarzyna, Wilmot, Jane, Evans, Michele, Roberts, Emma, Hu, Xiaoling, Furmaniak, Jadwiga, Rees Smith, Bernard

“…Binding of a new thyroid-stimulating human monoclonal autoantibody (MAb) K1–18 to the TSH receptor (TSHR) leucine-rich domain (LRD) was predicted using…”
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Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH by Sanders, Jane, Bolton, Jane, Sanders, Paul, Jeffreys, Jennifer, Nakatake, Nobuhiro, Richards, Tonya, Evans, Michele, Kiddie, Angela, Summerhayes, Sara, Roberts, Emma, Miguel, Ricardo Núñez, Furmaniak, Jadwiga, Smith, Bernard Rees

“…The effects of an extensive series of mutations in the TSH receptor (TSHR) leucine-rich domain (LRD) on the ability of thyroid-stimulating monoclonal…”
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The Crystal Structure of the BAR Domain from Human Bin1/Amphiphysin II and Its Implications for Molecular Recognition by Casal, Eva, Federici, Luca, Zhang, Wei, Fernandez-Recio, Juan, Priego, Eva-Maria, Miguel, Ricardo Nuñez, DuHadaway, James B, Prendergast, George C, Luisi, Ben F, Laue, Ernest D

“…BAR domains are found in proteins that bind and remodel membranes and participate in cytoskeletal and nuclear processes. Here, we report the crystal structure…”
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On the structure and function of apolipoproteins: more than a family of lipid-binding proteins by Bolanos-Garcia, Victor Martin, Miguel, Ricardo Nunez

“…Exchangeable apolipoproteins have been the subject of intense biomedical investigation for decades. However, only in recent years the elucidation of the…”
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Molecular interactions between the TSH receptor and a Thyroid-stimulating monoclonal autoantibody by Sanders, Jane, Miguel, Ricardo Núñez, Bolton, Jane, Bhardwaja, Anshu, Sanders, Paul, Nakatake, Nobuhiro, Evans, Michele, Furmaniak, Jadwiga, Smith, Bernard Rees

“…To study the molecular interactions between the thyroid-stimulating hormone (TSH) receptor (TSHR) and a human thyroid-stimulating monoclonal autoantibody…”
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