Regulation of Wnt/β-catenin pathway may be related to Regγ in benign epithelial odontogenic lesions

The aim of this study was to analyze and compare the immunoexpressions of Regγ, Wnt-1, and β-catenin in ameloblastomas, adenomatoid odontogenic tumors (AOTs), and odontogenic keratocysts (OKCs). Thirty solid ameloblastomas, 20 AOTs, and 30 OKCs were selected for analysis of the immunoexpression of R...

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Published in:	Oral surgery, oral medicine, oral pathology and oral radiology Vol. 128; no. 1; pp. 43 - 51
Main Authors:	Santos, Hellen Bandeira de Pontes, Medeiros, Hianne Cristinne de Morais, Mafra, Rodrigo Porpino, Miguel, Márcia Cristinada Costa, Galvão, Hébel Cavalcanti, de Souza, Lélia Batista
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-07-2019
Subjects:	Ameloblastoma Autoantigens beta Catenin Dentistry Humans Immunohistochemistry Odontogenic Tumors Proteasome Endopeptidase Complex Wnt Signaling Pathway
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Summary:	The aim of this study was to analyze and compare the immunoexpressions of Regγ, Wnt-1, and β-catenin in ameloblastomas, adenomatoid odontogenic tumors (AOTs), and odontogenic keratocysts (OKCs). Thirty solid ameloblastomas, 20 AOTs, and 30 OKCs were selected for analysis of the immunoexpression of Regγ, Wnt-1, and β-catenin. Each case was semiquantitatively evaluated in the epithelial component and in their different cellular compartments (membrane, cytoplasm, and nucleus). Ameloblastomas displayed higher cytoplasmic and nuclear Regγ expression compared with AOTs and OKCs, as well as higher membrane and cytoplasmic Wnt-1 expression (P < .05). β-catenin membrane expression was higher in OKCs compared with ameloblastomas and AOTs (P < .05). Nuclear β-catenin expression was higher in ameloblastomas and AOTs than in OKCs (P < .05). Cytoplasmic and nuclear Regγ expression in AOTs were positively correlated with nuclear β-catenin expression (P < .05). The marked expressions of Regγ, Wnt-1, and β-catenin suggest the participation of these proteins in the pathogenesis of the studied lesions. The greater expressions of Regγ, Wnt-1, and nuclear β-catenin in ameloblastomas may be related to their more aggressive behavior. Pro-tumor effects of nuclear β-catenin may be counterbalanced by inhibitory pathways in AOTs, justifying their low aggressiveness.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2212-4403 2212-4411
DOI:	10.1016/j.oooo.2018.12.019