Search Results - "Mignen, Olivier"

Orai1 subunit stoichiometry of the mammalian CRAC channel pore by Mignen, Olivier, Thompson, Jill L., Shuttleworth, Trevor J.

“…Agonist-activated Ca 2+ entry plays a critical role in Ca 2+ signalling in non-excitable cells. One mode of such entry is activated as a consequence of the…”
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Ca2+ protein alpha 1D of CaV1.3 regulates intracellular calcium concentration and migration of colon cancer cells through a non-canonical activity by Fourbon, Yann, Guéguinou, Maxime, Félix, Romain, Constantin, Bruno, Uguen, Arnaud, Fromont, Gaëlle, Lajoie, Laurie, Magaud, Christophe, Lecomte, Thierry, Chamorey, Emmanuel, Chatelier, Aurélien, Mignen, Olivier, Potier-Cartereau, Marie, Chantôme, Aurélie, Bois, Patrick, Vandier, Christophe

“…It is generally accepted that voltage-gated Ca 2+ channels, CaV, regulate Ca 2+ homeostasis in excitable cells following plasma membrane depolarization. Here,…”
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Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity by Hemon, Patrice, Renaudineau, Yves, Debant, Marjolaine, Le Goux, Nelig, Mukherjee, Sreya, Brooks, Wesley, Mignen, Olivier

“…Maintenance of self-tolerance of auto-reactive lymphocytes is a fundamental mechanism to prevent the onset of autoimmune diseases. Deciphering the mechanisms…”
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Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels by Mignen, Olivier, Thompson, Jill L., Shuttleworth, Trevor J.

“…Agonist-activated Ca 2+ signals in non-excitable cells are profoundly influenced by calcium entry via both store-operated and store-independent conductances…”
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The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits by Mignen, Olivier, Thompson, Jill L., Shuttleworth, Trevor J.

“…The activation of Ca 2+ entry is a critical component of agonist-induced cytosolic Ca 2+ signals in non-excitable cells. Although a variety of different…”
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STIM1 regulates Ca2+ entry via arachidonate-regulated Ca2+-selective (ARC) channels without store depletion or translocation to the plasma membrane by Mignen, Olivier, Thompson, Jill L., Shuttleworth, Trevor J.

“…Recent studies have indicated a critical role for STIM (stromal interacting molecule) proteins in the regulation of the store-operated mode of…”
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Major Role for TRPV1 and InsP3R in PAR2-Elicited Inflammatory Mediator Production in Differentiated Human Keratinocytes by Gouin, Olivier, L'Herondelle, Killian, Buscaglia, Paul, Le Gall-Ianotto, Christelle, Philippe, Réginald, Legoux, Nelig, Mignen, Olivier, Buhé, Virginie, Leschiera, Raphael, Sakka, Mehdi, Kerfant, Nathalie, Carré, Jean-Luc, Le Garrec, Raphaele, Lefeuvre, Luc, Lebonvallet, Nicolas, Misery, Laurent

“…PAR2 activation in basal keratinocytes stimulates inflammation via the Ca2+-dependent production of mediators such as IL-1β, TNF-α, and TSLP. In this study, we…”
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The diversity of the plasmablast signature across species and experimental conditions: A meta‐analysis by Grasseau, Alexis, Boudigou, Marina, Michée‐Cospolite, Magalie, Delaloy, Céline, Mignen, Olivier, Jamin, Christophe, Cornec, Divi, Pers, Jacques‐Olivier, Le Pottier, Laëtitia, Hillion, Sophie

“…Antibody‐secreting cells (ASC) are divided into two principal subsets, including the long‐lived plasma cell (PC) subset residing in the bone marrow and the…”
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Molecular Mechanisms Driving IL-10- Producing B Cells Functions: STAT3 and c-MAF as Underestimated Central Key Regulators? by Michée-Cospolite, Magalie, Boudigou, Marina, Grasseau, Alexis, Simon, Quentin, Mignen, Olivier, Pers, Jacques-Olivier, Cornec, Divi, Le Pottier, Laëtitia, Hillion, Sophie

“…Regulatory B cells (Bregs) have been highlighted in very different pathology settings including autoimmune diseases, allergy, graft rejection, and cancer…”
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Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis by L'Herondelle, Killian, Talagas, Matthieu, Mignen, Olivier, Misery, Laurent, Le Garrec, Raphaele

“…Ciguatera fish poisoning (CFP), the most prevalent seafood poisoning worldwide, is caused by the consumption of tropical and subtropical fish contaminated with…”
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CD5 and B lymphocyte responses: multifaceted effects through multitudes of pathways and channels by Taher, Taher E., Bystrom, Jonas, Mignen, Olivier, Pers, Jacques-Olivier, Renaudineau, Yves, Mageed, Rizgar A.

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Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research by Potier-Cartereau, Marie, Raoul, William, Weber, Günther, Mahéo, Karine, Rapetti-Mauss, Raphaël, Gueguinou, Maxime, Buscaglia, Paul, Goupille, Caroline, Le Goux, Nelig, Abdoul-Azize, Souleymane, Lecomte, Thierry, Fromont, Gaëlle, Chantôme, Aurélie, Mignen, Olivier D, Soriani, Olivier, Vandier, Christophe

“…The intracellular Ca2+ concentration is mainly controlled by Ca2+ channels. These channels form complexes with K+ channels, which function to amplify Ca2+…”
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Design and Synthesis of Novel N-Benzylidene Derivatives of 3-Amino-4-imino-3,5-dihydro-4H-chromeno[2,3-d]pyrimidine under Microwave, In Silico ADME Predictions, In Vitro Antitumoral Activities and In Vivo Toxicity by Karoui, Sirine, Dhiabi, Marwa, Fakhfakh, Mehdi, Abid, Souhir, Limanton, Emmanuelle, Le Guével, Rémy, Charlier, Thierry D., Mainguy, Anthony, Mignen, Olivier, Paquin, Ludovic, Ammar, Houcine, Bazureau, Jean-Pierre

“…The synthesis of a series of new N-benzylidene derivatives of 3-amino-4-imino-3,5-dihydro-4H-chromeno[2,3-d]pyrimidine 10(a-l) bearing two points of molecular…”
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LKB1‐SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition by Proteau, Sarah, Krossa, Imène, Husser, Chrystel, Guéguinou, Maxime, Sella, Federica, Bille, Karine, Irondelle, Marie, Dalmasso, Mélanie, Barouillet, Thibault, Cheli, Yann, Pisibon, Céline, Arrighi, Nicole, Nahon‐Estève, Sacha, Martel, Arnaud, Gastaud, Lauris, Lassalle, Sandra, Mignen, Olivier, Brest, Patrick, Mazure, Nathalie M, Bost, Frédéric, Baillif, Stéphanie, Landreville, Solange, Turcotte, Simon, Hasson, Dan, Carcamo, Saul, Vandier, Christophe, Bernstein, Emily, Yvan‐Charvet, Laurent, Levesque, Mitchell P, Ballotti, Robert, Bertolotto, Corine, Strub, Thomas

“…Metastatic uveal melanomas are highly resistant to all existing treatments. To address this critical issue, we performed a kinome‐wide CRISPR‐Cas9 knockout…”
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New insights into the regulation of Cystathionine beta synthase (CBS) , an enzyme involved in intellectual deficiency in Down syndrome by Conan, Pierre, Léon, Alice, Caroff, Noéline, Rollet, Claire, Chaïr, Loubna, Martin, Jennifer, Bihel, Frédéric, Mignen, Olivier, Voisset, Cécile, Friocourt, Gaëlle

“…Down syndrome (DS), the most frequent chromosomic aberration, results from the presence of an extra copy of chromosome 21. The identification of genes which…”
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Publisher Correction: LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition by Proteau, Sarah, Krossa, Imène, Husser, Chrystel, Guéguinou, Maxime, Sella, Federica, Bille, Karine, Irondelle, Marie, Dalmasso, Mélanie, Barouillet, Thibault, Cheli, Yann, Pisibon, Céline, Arrighi, Nicole, Nahon-Estève, Sacha, Martel, Arnaud, Gastaud, Lauris, Lassalle, Sandra, Mignen, Olivier, Brest, Patrick, Mazure, Nathalie M, Bost, Frédéric, Baillif, Stéphanie, Landreville, Solange, Turcotte, Simon, Hasson, Dan, Carcamo, Saul, Vandier, Christophe, Bernstein, Emily, Yvan-Charvet, Laurent, Levesque, Mitchell P, Ballotti, Robert, Bertolotto, Corine, Strub, Thomas

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The p.E152K-STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis by Burgos, Miguel, Philippe, Reginald, Antigny, Fabrice, Buscaglia, Paul, Masson, Emmanuelle, Mukherjee, Sreya, Dubar, Pauline, Le Maréchal, Cédric, Campeotto, Florence, Lebonvallet, Nicolas, Frieden, Maud, Llopis, Juan, Domingo, Beatriz, Stathopulos, Peter B., Ikura, Mitsuhiko, Brooks, Wesley, Guida, Wayne, Chen, Jian-Min, Ferec, Claude, Capiod, Thierry, Mignen, Olivier

“…ABSTRACT Since deregulation of intracellular Ca2+ can lead to intracellular trypsin activation, and stromal interaction molecule-1 (STIM1) protein is the main…”
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Identification of 8-Hydroxyquinoline Derivatives That Decrease Cystathionine Beta Synthase (CBS) Activity by Conan, Pierre, Léon, Alice, Gourdel, Mathilde, Rollet, Claire, Chaïr, Loubna, Caroff, Noéline, Le Goux, Nelig, Le Jossic-Corcos, Catherine, Sinane, Maha, Gentile, Lucile, Maillebouis, Louise, Loaëc, Nadège, Martin, Jennifer, Vilaire, Marie, Corcos, Laurent, Mignen, Olivier, Croyal, Mikael, Voisset, Cécile, Bihel, Frédéric, Friocourt, Gaëlle

“…CBS encodes a pyridoxal 5′-phosphate-dependent enzyme that catalyses the condensation of homocysteine and serine to form cystathionine. Due to its implication…”
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Pacific-Ciguatoxin-2 and Brevetoxin-1 Induce the Sensitization of Sensory Receptors Mediating Pain and Pruritus in Sensory Neurons by Pierre, Ophélie, Fouchard, Maxime, Le Goux, Nelig, Buscaglia, Paul, Leschiera, Raphaël, Lewis, Richard J, Mignen, Olivier, Fluhr, Joachim W, Misery, Laurent, Le Garrec, Raphaële

“…Ciguatera fish poisoning (CFP) and neurotoxic shellfish poisoning syndromes are induced by the consumption of seafood contaminated by ciguatoxins and…”
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Preliminary Structure-Activity Relationship (SAR) of a Novel Series of Pyrazole SKF-96365 Analogues as Potential Store-Operated Calcium Entry (SOCE) Inhibitors by Dago, Camille D, Maux, Paul Le, Roisnel, Thierry, Brigaudeau, Christophe, Bekro, Yves-Alain, Mignen, Olivier, Bazureau, Jean-Pierre

“…From a series of (1 , 1 )-1[β-(phenylalkoxy)-(phenetyl)]-1 -pyrazolium hydrochloride as new analogues of SKF-96365, one has an interesting effect for…”
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